Artículos de revistas
Pancreatic Islets Isolated From β2 Adrenergic Receptor Knockout Mice Show Reduced Insulin Secretion In Response To Nutrients [ilhotas Pancreaśticas Isoladas De Camundongos Com Deleção Do Receptor Adrenérgico β2 Apresenta Reduzida Secreção De Insulina Em Resposta A Nutrientes]
Registro en:
Acta Scientiarum - Biological Sciences. , v. 35, n. 3, p. 437 - 443, 2013.
16799283
10.4025/actascibiolsci.v35i3.15842
2-s2.0-84881047262
Autor
Marcal A.C.
Davel A.P.C.
Carpinelli A.R.
Brum P.C.
Rossoni L.V.
Carvalho C.R.O.
Institución
Resumen
Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice. β2KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β2KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β2KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β2KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β2KO mice. These results suggested a possible role of β2 adrenergic receptors on nutrient-induced insulin secretion. 35 3 437 443 Ahrén, B., Autonomic regulation of islet hormone secretion-implications for health and disease (2000) Diabetologia, 43 (4), pp. 393-410 Ahrén, B., Lundquist, I., Effects of selective and non-selective β-adrenergic agents on insulin secretion in vivo (1981) European Journal of Endocrinology, 71 (1), pp. 93-104 Asensio, C., Jimenez, M., Rohner-Jeanrenaud, F., The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance (2005) Diabetes, 54 (12), pp. 3490-3495 Ashcroft, F.M., ATP-sensitive potassium channelopathies: Focus on insulin secretion (2005) The Journal of Clinical Investigation, 115 (8), pp. 2047-2058 Berlan, M., Dang, T.L., The role of beta and alpha adrenergic receptors in the lipolytic effect of catecholamines on dog adipocytes (1978) Journal De Physiologie, 74 (6), pp. 601-608 Blachier, F., Leclerq-Meyer, V., Marchand, J., Marchand, J., Woussen-Cole, M.C., Mathias, P.C., Sener, A., Malaisse, W.J., Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to L-arginine and L-ornithine (1989) Biochimica Et Biophysica Acta, 1013 (2), pp. 144-151 Bonen, A., MeGeney, L.A., McCarthy, S.C., McDermott, J.C., Tan, M.H., Epinephrine administration stimulates GLUT4 translocation but reduces glucose transport in muscle (1992) Biochemical and Biophysical Research Communications, 187 (2), pp. 685-691 Brum, P.C., Rolim, N.P., Bacurau, A.V., Medeiros, A., Neurohumoral activation in heart failure: The role of adrenergic receptors (2006) Anais Da Academia Brasileira De Ciências, 78 (3), pp. 485-503 Carpinelli, A.R., Malaisse, W.J., Regulation of 86Rb outflow from pancreatic islets: The dual effect of nutrient secretagogues (1981) The Journal of Physiololgy, 315, pp. 143-156 Carvalho, E., Jansson, P.A., Axelsen, M., Eriksson, J.W., Huang, X., Groop, L., Rondinone, C., Smith, U., Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM (1999) The FASEB Journal, 13 (15), pp. 2173-2178 Charles, S., Tamagawa, T., Henquin, J.C., A single mechanism for the stimulation of insulin release and 86Rb+ efflux from rat islets by cationic amino acids (1982) The Biochemical Journal, 208 (2), pp. 301-308 Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K., Targeted disruption of the beta2 adrenergic receptor gene (1999) Journal of Biological Chemistry, 274 (24), pp. 16694-16700 Doronin, S., Wang, H., Malbon, C.C., Insulin stimulates phosphorylation of β2-adrenergic receptor by the insulin receptor, creating a potent feedback inhibitor of its tyrosine kinase (2002) Journal of Biological Chemistry, 277 (12), pp. 10698-10703 Fisher, R.A., Kumar, R., Hanahan, D.J., Olson, M.S., Effects of beta-adrenergic stimulation on 1- O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver (1986) Jounal of Biological Chemistry, 261 (19), pp. 8817-8823 Graphpad, P.R.I.S.M., (2003) User's Guide. Version 4.00 For Windows, , San Diego: GraphPad Software. Inc Gylfe, E., Comparison of the effects of leucines, non- metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase (1976) Acta Diabetologica Latina, 13 (1-2), pp. 20-24 Han, X.X., Bonen, A., Epinephrine translocates GLUT-4 but inhibits insulin-stimulated glucose transport in rat muscle (1998) American Journal of Physiology, 274 (4), pp. 700-707 Henquin, J.C., Meissner, H.P., Effects of amino acids on membrane potential and 86Rb+ fluxes in pancreatic β-cells (1981) American Journal of Physiology, 240 (3), pp. 245-252 Henquin, J.C., Ravier, M.A., Nenquin, M., Jonas, J.C., Gilon, P., Hierarchy of the β-cell signals controlling insulin secretion (2003) European Journal of Clinical Investigation, 33 (9), pp. 742-750 Hermans, M.P., Schmeer, W., Henquin, J.C., The permissive effect of glucose, tolbutamide and high K+ on arginine stimulation of insluin release in isolated mouse islets (1987) Diabetologia, 30 (8), pp. 659-665 Jones, J.P., Dohm, G.L., Regulation of glucose transporter GLUT4 and hexokinase II gene transcription by insulin and epinephrine (1997) American Journal of Physiology, 273 (4), pp. E682-E687 Kurose, T., Seino, Y., Nishi, S., Tsuji, K., Taminato, T., Tsuda, K., Imura, H., Mechanism of sympathetic neural regulation of insulin, somatostatin, and glucagon secretion (1990) American Journal of Physiology, 258 (1), pp. E220-E227 Latorraca, M.Q., Carneiro, E.M., Mello, M.A., Boschero, A.C., Reduced insulin secretion in response to nutrients in islets from malnourished young rats is associated with a diminished calcium uptake (1999) The Journal of Nutrition of Biochemistry, 10 (1), pp. 37-43 Laurent, D., Petersen, K.F., Russel, R.R., Cline, G.W., Shulman, G.I., Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans (1998) American Journal of Physiology, 274 (1), pp. E130-E138 Macdonald, P.E., Joseph, J.W., Rorsman, P., Glucose-sensing mechanisms in pancreatic β-cells Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360 (1464), pp. 2211-2225 Marçal, A.C., Camporez, J.P.G., Lima-Salgado, T.M., Cintra, D.E., Akamine, E.H., Ribeiro, L.M., Almeida, F.N., Carvalho, C.R.O., Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium- chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets (2012) British Journal of Nutrition, 27, pp. 1-12 Marçal, A.C., Grassiolli, S., Da Rocha, D.N., Puzzi, M.A., Gravena, C., Scomparin, D.X., De Freitas, M.P.C., The dual effect of isoproterenol on insulin release is suppressed in pancreatic islets from hypothalamic obese rats (2006) Endocrine, 29 (3), pp. 445-449 Medeiros, A., Rolim, N.P., Oliveira, R.S., Rosa, K.T., Mattos, K.C., Casarini, D.E., Irigoyen, M.C., Brum, P.C., Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice (2008) The Journal of Applied Physiology, 104 (1), pp. 103-109 Miller, R.E., Pancreatic neuroendocrinology: Peripheral neural mechanisms in the regulation of the islets of Langerhans (1981) Endocrine Reviews, 2 (4), pp. 471-494 Narimiya, M., Yamada, H., Matsuba, I., Ikeda, Y., Tanese, T., Abe, M., Adrenergic modulation of insulin and glucagon secretion from the isolated perfused rat pancreas (1981) Endocrinologia Japonica, 28 (3), pp. 281-292 Nishimura, H., Saltis, J., Habberfield, A.D., Garty, N.B., Greenberg, A.S., Cushman, S.W., Londos, C., Simpson, I.A., Phosphorylation state of the GLUT4 isoform of the glucose transporter in subfractions of the rat adipose cell: Effects of insulin, adenosine, and isoproterenol (1991) Proceedings of the National Academy of Sciences of the United States of America, 88 (24), pp. 11500-11504 Panten, U., Kriegstein, E., Poses, W., Schönborn, J., Hasselblatt, A., Effects of L- Leucine and α-ketoisocaproic acid upon insulin secretion and metabolism of isolated pancreatic islets (1972) FEBS Letters, 20 (2), pp. 225-228 Peterhoff, M., Sieg, A., Brede, M., Chao, C.M., Hein, L., Ulrich, S., Inhibition of insulin secretion via distinct signaling pathways in alpha2- adrenoceptor knockout mice (2003) European Journal of Endocrinology, 149 (4), pp. 343-350 Rogers, P., Webb, G.B., Estimation of body fat in normal and obese mice (1980) The British Journal of Nutrition, 43 (1), pp. 83-86 Saltiel, A.R., Kahn, C.R., Insulin signalling and the regulation of glucose and lipid metabolism (2001) Nature, 414 (6865), pp. 799-806 Sener, A., Malaisse, W.J., L-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dhydrogenase (1980) Nature, 288 (5787), pp. 187-189 Sjoholm, A., Alpha-adrenergic inhibition of rat pancreatic beta-cell replication and insulin secretion is mediated through a pertussis toxin-sensitive G-protein regulating islet cAMP content (1991) Biochemical and Biophysical Research Communications, 180 (1), pp. 152-155 Smith, P.A., Sakura, H., Coles, B., Gummerson, N., Proks, P., Ashcroft, F.M., Electrogenic arginine transport mediates stimulus-secretion coupling im mouse pancreatic β-cells (1997) The Journal of Physiology, 499, pp. 625-635 Weinhaus, A.J., Poronnik, P., Tuch, B.E., Cook, D.I., Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1 (1997) Diabetologia, 40 (4), pp. 374-382 Yamauchi, T., Tobe, K., Tamemoto, H., Ueki, K., Kaburagi, Y., Yamamoto-Honda, R., Takahashi, Y., Kadowaki, T., Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice (1996) Molecular and Cellular Biology, 16 (6), pp. 3074-3084 Yang, J., Hodel, A., Holman, G.D., Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane (2002) Jounal of Biological Chemistry, 277 (8), pp. 6559-6566 White, M.F., Kahn, C.R., The insulin signaling system (1994) Journal of Biological Chemistry, 269 (1), pp. 1-4 Zanquetta, M.M., Nascimento, M.E., Mori, R.C., D'Agord, S.B., Young, M.E., Machado, U.F., Participation of beta-adrenergic activity in modulation of GLUT4 expression during fasting and refeeding in rats (2006) Metabolism, 55 (11), pp. 1538-1545