| dc.creator | Nunes L.A.S. | |
| dc.creator | Macedo D.V.D. | |
| dc.date | 2013 | |
| dc.date | 2015-06-25T19:09:30Z | |
| dc.date | 2015-11-26T15:07:31Z | |
| dc.date | 2015-06-25T19:09:30Z | |
| dc.date | 2015-11-26T15:07:31Z | |
| dc.date.accessioned | 2018-03-28T22:17:56Z | |
| dc.date.available | 2018-03-28T22:17:56Z | |
| dc.identifier | | |
| dc.identifier | Jornal Brasileiro De Patologia E Medicina Laboratorial. , v. 49, n. 4, p. 247 - 255, 2013. | |
| dc.identifier | 16762444 | |
| dc.identifier | 10.1590/S1676-24442013000400003 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84891409646&partnerID=40&md5=a6cf7fc276e1a7fc287764569bf0f948 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/88311 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/88311 | |
| dc.identifier | 2-s2.0-84891409646 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1257474 | |
| dc.description | The use of saliva in the diagnosis of pathologies and/or monitoring of athletes in competitions or trainings is an attractive alternative due to the fact that samples are easily obtained and it is mostly a less invasive method in comparison with venous blood collection. The saliva is a hypotonic fluid in relation to plasma, containing compounds produced in the salivary glands (immunoglobulin A [IgA] and ?-amylase) as well as compounds diffused in the plasma (water, electrolytes, proteins, metabolites and hormones). It plays a pivotal role in the protection of oral mucosa against microbes and in food digestion. Its production and composition depend on the sympathetic and parasympathetic nervous system activity, whose antagonistic action may result in different saliva volumes with distinct ionic and protein profiles. The aim of this review was to present a critical analysis of the potential and limitations of saliva as a diagnostic tool in sports medicine. Although there are studies that have deployed it to monitor athletes in training and doping, the standardization of some preanalytical variables are still required, among which the following ones are worth mentioning: the accurate choice of collection system, which allows the easy quantification of volume with adequate sample recovery; well-defined collection schedules in accordance with the circadian variations of the analyte; prevention of sample contamination with blood from oral mucosa lesions. Another key point for its application in sports is the establishment of reference intervals for analytes quantified in the saliva, collected from a population that comprises healthy individual that exercise regularly and systematically, with physical activity progression © agosto 2013. | |
| dc.description | 49 | |
| dc.description | 4 | |
| dc.description | 247 | |
| dc.description | 255 | |
| dc.description | Allgrove, J.E., Effects of exercise intensity on salivary antimicrobial proteins and markers of stress in active men (2008) J Sports Sci, 26 (6), pp. 653-661 | |
| dc.description | Aps, J.K., Review, C.M.L., The physiology of saliva and transfer of drugs into saliva (2005) Forensic Sci Int, 150, pp. 119-131 | |
| dc.description | Aubets, J., Segura, J., Salivary cortisol as a marker of competition related stress (1995) Science & Sports, 10, pp. 149-154 | |
| dc.description | Bishop, N.C., Gleeson, M., Acute and chronic effects of exercise on markers of mucosa immunity (2009) Front Biosci, 14, pp. 4444-4456 | |
| dc.description | Blannin, P.J., The effect of exercising to exhaustion at different intensities on saliva immunoglobulin A, protein and electrolyte secretion (1998) Int J Sports Med, 19, pp. 546-552 | |
| dc.description | Blicharz, T.M., Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: A proof of principle (2008) Clin Chem, 54 (9), pp. 1473-1480 | |
| dc.description | Calvo, F., Anaerobic threshold determination with analysis of salivary amylase (1997) Can J Appl Physiol, 22, pp. 553-561 | |
| dc.description | Cardoso, E.M.L., Assessment of salivary urea as a less invasive alternative to serum determinations (2009) Scand J Clin Lab Invest, 69 (3), pp. 330-334 | |
| dc.description | Chatterton, R.T., Salivary alpha-amylase as a measure of endogenous adrenergic activity (1996) Clin Physiol, 16 (4), pp. 433-438 | |
| dc.description | Chiappin, S., Saliva specimen: A new laboratory tool diagnostic and basic investigation (2007) Clin Chim Acta, 383, pp. 30-40 | |
| dc.description | Chicharro, J.L., Saliva composition and exercise (1998) Sports Med, 26 (1), pp. 17-27 | |
| dc.description | Chicharro, J.L., Saliva electrolytes as a useful tool for anaerobic threshold determination (1994) Eur J Appl Physiol, 68, pp. 1495-1497 | |
| dc.description | De Oliveira, V.N., Changes in the salivary biomarkers induced by an effort test (2010) Int J Sports Med, 31, pp. 377-381 | |
| dc.description | Decaro, J.A., Methodological considerations in the use of salivary a-amylase as a stress marker in field research (2008) Am J Hum Biol, 20, pp. 617-619 | |
| dc.description | Denny, P., The proteome of human parotid and submandibular sublingual gland salivas collected as the ductal secretions (2008) J Proteome Res, 7, pp. 1994-2006 | |
| dc.description | Fox, P.C., Xerostomia: Evaluation of a symptom with increasing significance (1985) J Am Dent Assoc, 110 (4), pp. 519-525 | |
| dc.description | Gallagher, P., Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: Effects of collection method (2006) J Psychopharmacol, 20 (5), pp. 643-649 | |
| dc.description | Gleeson, M., Pyne, D.B., Exercise effects on mucosa immunity (2000) Immunol Cell Biol, 78, pp. 536-544 | |
| dc.description | Gonzalez, D., Marquina, R., Rondón, N., Effects of aerobic exercise on uric acid, total antioxidant activity, oxidative stress, and nitric oxide in human saliva (2008) Res Sports Med, 16, pp. 128-137 | |
| dc.description | Granger, D.A., Salivary á-amylase in biobehavioral research (2007) Ann NY Acad Sci, 1098, pp. 122-144 | |
| dc.description | Grschl, M., Current status of salivary hormone analysis (2008) Clin Chem, 54 (11), pp. 1759-1769 | |
| dc.description | Grschl, M., Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs (2008) J Pharma Biomed Anal, 47, pp. 478-486 | |
| dc.description | Hansen, A.M., Evaluation of a radioimmunoassay and establishment of a reference interval for salivary cortisol in healthy subjects in Denmark (2003) Scand J Clin Lab Invest, 63, pp. 303-310 | |
| dc.description | Hansen, A.M., Garde, A.H., Persson, R., Sources of biological and methodological variation in salivary cortisol and their impact on measurement among healthy adults: A review (2008) Scand J Clin Lab Invest, 68 (6), pp. 448-458 | |
| dc.description | Hu, S., Large scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and twodimensional gel electrophoresis mass spectrometry (2005) Proteomics, 5, pp. 1714-1728 | |
| dc.description | Huang, C.M., Comparative proteomic analysis of human whole saliva (2004) Arch Oral Biol, 49 (12), pp. 951-962 | |
| dc.description | Humphrey, S.P., Williamson, R.T., A review of saliva: Normal composition, flow, and function (2001) J Prosthet Dent, 85 (2), pp. 162-169 | |
| dc.description | Jou, Y.J., Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer (2010) Anal Chim Acta, 681, pp. 41-48 | |
| dc.description | Kalk, W.W.I., Sialometry and sialochemistry: A non-invasive approach for diagnosing Sjgrens syndrome (2002) Ann Rheum Dis, 61, pp. 137-144 | |
| dc.description | Kaufman, E., Lamster, I.B., The diagnostic application of saliva (2002) Crit Rev Oral Biol Med, 13 (2), pp. 197-202 | |
| dc.description | Kraemer, W.J., Ratamess, N.A., Hormonal responses and adaptations to resistance exercise and training (2005) Sports Med, 35 (4), pp. 339-361 | |
| dc.description | Langman, L.J., The use of oral fluid for therapeutic drug management (2007) Ann NY Acad Sci, 1098, pp. 145-166 | |
| dc.description | Levine, M.J., Salivary macromolecules. A structure/function synopsis (1993) Ann N y Acad Sci, 20 (694), pp. 11-16 | |
| dc.description | Li, T.L., Gleeson, M., The effect of single and repeated bouts of prolonged cycling and circadian variation on saliva flow rate, immunoglobulin A and-amylase responses (2004) J Sports Sci, 22, pp. 1015-1024 | |
| dc.description | Lippi, G., Measurement of morning saliva cortisol in athletes (2009) Clin Biochem, 42, pp. 904-906 | |
| dc.description | McDowell, S.L., The effect of exercise intensity and duration on salivary immunoglobulin A (1991) Eur J Appl Physiol, 63, pp. 108-111 | |
| dc.description | Michishige, F., Effect of saliva collection method on the concentration of protein components in saliva (2006) J Med Invest, 53, pp. 140-146 | |
| dc.description | Nagler, R.M., Characterization of the differentiated antioxidant profile of human saliva (2002) Free Radic Biol Med, 32 (3), pp. 268-277 | |
| dc.description | Nater, U.M., Determinants of the diurnal course of salivary alpha-amylase (2007) Psychoneuroendocrinology, 32, pp. 392-401 | |
| dc.description | Nater, U.M., Human salivary alpha-amylase reactivity in a psychosocial stress paradigm (2005) Int J Psychophysiol, 55 (3), pp. 333-342 | |
| dc.description | Nater, U.M., Rohleder, N., Salivary alpha-amylase as a noninvasive biomarker for the sympathetic nervous system: Current state of research (2009) Psychoneuroendocrinology, 34, pp. 486-496 | |
| dc.description | Nieman, D.C., Change in salivary IgA following a competitive marathon race (2002) Int J Sports Med, 23, pp. 69-75 | |
| dc.description | Nieuw Amerongen, A.V., Ligttenberg, A.J., Veerman, E.C., Implications for diagnostics in the biochemistry and physiology of saliva (2007) Ann NY Acad Sci, 1098, pp. 1-6 | |
| dc.description | Nunes, L.A.S., Adequacies of skin puncture for evaluating biochemical and hematological parameters in athletes (2006) Clin J Sport Med, 16 (5), pp. 418-421 | |
| dc.description | Nunes, L.A.S., Reference intervals for saliva analytes collected by a standardized method in a physically active population (2011) Clin Biochem, 44, pp. 1440-1444 | |
| dc.description | Ohkuwa, T., Salivary and blood lactate after supramaximal exercise in sprinters and long distance runners (1995) Scand J Med Sci Sports, 5, pp. 285-290 | |
| dc.description | Owen-Smith, B., Quiney, J., Read, J., Salivary urate in gout, exercise and diurnal variation (1998) Lancet, 351 (27), p. 1932 | |
| dc.description | Patel, R.S., Production of gender-specific morning salivary cortisol reference intervals using internationally accepted procedures (2004) Clin Chem Lab Med, 42 (12), pp. 1424-1429 | |
| dc.description | Raggam, R.B., Evaluation of a novel standardized system for collection and quantification of oral fluid (2008) Clin Chem Lab Med, 46 (92), pp. 287-291 | |
| dc.description | Raggam, R.B., Reliable detection and quantification of viral nucleic acids in oral fluid: Liquid phase-based sample collection in conjunction with automated and standardized molecular assays (2008) J Med Virol, 80, pp. 1684-1688 | |
| dc.description | Rao, P.V., Proteomic identification of salivary biomarkers of type- 2 diabetes (2009) J Proteome Res, 8 (1), pp. 239-245 | |
| dc.description | Rehak, N.N., Cecco, S.A., Csako, G., Biochemical composition and electrolyte balance of unstimulated whole human saliva (2000) Clin Chem Lab Med, 38 (4), pp. 335-343 | |
| dc.description | Sapolsky, R.M., Romero, L.M., Munck, A.U., How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions (2000) Endocr Rev, 21, pp. 55-89 | |
| dc.description | Schwartz, E.B., Granger, D.A., Transferrin enzyme immunoassay for quantitative monitoring of blood contamination in saliva (2004) Clin Chem, 50 (3), pp. 546-555 | |
| dc.description | Strano-Rossi, S., Analysis of stimulants in oral fluid and urine by gas chromatography-mass spectrometry II: Pseudoephedrine (2010) J Anal Toxicol, 34 (4), pp. 210-215 | |
| dc.description | Trilck, M., Salivary cortisol measurement - A reliable method for diagnosis of cushings syndrome (2005) Exp Clin Endocrinol Diabetes, 113, pp. 225-230 | |
| dc.description | Urhausen, A., Kindermann, W., Diagnosis of overtraining. What tools do we have? (2002) Sports Med, 32 (2), pp. 95-102 | |
| dc.description | Vining, R.F., McGinley, R.A., Symons, R.G., Hormones in saliva: Mode of entry and consequent implications for clinical interpretation (1983) Clin Chem, 29 (10), pp. 1752-1756 | |
| dc.description | Walsh, N.P., Salivary IgA response to prolonged exercise in a cold environment in trained cyclists (2002) Med Sci Sports Exerc, 34, pp. 1632-1637 | |
| dc.description | Wong, D.T., Salivary diagnostics powered by nanotechnologies, proteomics and genomics (2006) JADA, 137, pp. 313-321 | |
| dc.description | Youssef, H., Comparison of total antioxidant capacity of salivary, capillary and venous samplings: Interest of the salivary total antioxidant capacity on triathletes during training season (2008) J Sports Med Phys Fitness, 48, pp. 522-529 | |
| dc.language | en | |
| dc.publisher | | |
| dc.relation | Jornal Brasileiro de Patologia e Medicina Laboratorial | |
| dc.rights | aberto | |
| dc.source | Scopus | |
| dc.title | Saliva As A Diagnostic Fluid In Sports Medicine: Potential And Limitations | |
| dc.type | Artículos de revistas | |
