Brasil | Artículos de revistas

Modulatory Effects Of Yerba Maté (ilex Paraguariensis) On The Pi3k-akt Signaling Pathway

dc.creatorArcari D.P.
dc.creatorSantos J.C.
dc.creatorGambero A.
dc.creatorFerraz L.F.C.
dc.creatorRibeiro M.L.
dc.date2013
dc.date2015-06-25T19:09:22Z
dc.date2015-11-26T15:07:23Z
dc.date2015-06-25T19:09:22Z
dc.date2015-11-26T15:07:23Z
dc.date.accessioned2018-03-28T22:17:47Z
dc.date.available2018-03-28T22:17:47Z
dc.identifier
dc.identifierMolecular Nutrition And Food Research. , v. 57, n. 10, p. 1882 - 1885, 2013.
dc.identifier16134125
dc.identifier10.1002/mnfr.201200834
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84884913712&partnerID=40&md5=0b6f90e8e6b098bb9f02eb6e168a2284
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88284
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88284
dc.identifier2-s2.0-84884913712
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257442
dc.descriptionThe aim of this study was to evaluate the effects of yerba maté (YM) extract on the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway in vivo. The mice were introduced to either standard- or high-fat diet (HFD). After 8 weeks on an HFD, mice were randomly assigned to one of the two treatment conditions, water or yerba maté extract at 1.0 g/kg. After treatment, glucose blood level and hepatic insulin response were evaluated. Liver tissue was examined to determine the mRNA levels using the PI3K-AKT PCR array. The nuclear translocation of forkhead box O1 (FOXO1) was determined by an electrophoretic mobility-shift assay. Our data demonstrated that yerba maté extract significantly decreased the final body weight, glucose blood levels, and insulin resistance of mice. Molecular analysis demonstrated that an HFD downregulated Akt2, Irs1, Irs2, Pi3kca, Pi3kcg, and Pdk1; after yerba maté treatment, the levels of those genes returned to baseline. In addition, an HFD upregulated Pepck and G6pc and increased FOXO1 nuclear translocation. The intervention downregulated these genes by decreasing FOXO1 nuclear translocation. The results obtained demonstrate for the first time the specific action of yerba maté on the PI3K-AKT pathway, which contributed to the observed improvement in hepatic insulin signaling. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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dc.languageen
dc.publisher
dc.relationMolecular Nutrition and Food Research
dc.rightsfechado
dc.sourceScopus
dc.titleModulatory Effects Of Yerba Maté (ilex Paraguariensis) On The Pi3k-akt Signaling Pathway
dc.typeArtículos de revistas


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