dc.creator | Lourenco M.V. | |
dc.creator | Clarke J.R. | |
dc.creator | Frozza R.L. | |
dc.creator | Bomfim T.R. | |
dc.creator | Forny-Germano L. | |
dc.creator | Batista A.F. | |
dc.creator | Sathler L.B. | |
dc.creator | Brito-Moreira J. | |
dc.creator | Amaral O.B. | |
dc.creator | Silva C.A. | |
dc.creator | Freitas-Correa L. | |
dc.creator | Espirito-Santo S. | |
dc.creator | Campello-Costa P. | |
dc.creator | Houzel J.-C. | |
dc.creator | Klein W.L. | |
dc.creator | Holscher C. | |
dc.creator | Carvalheira J.B. | |
dc.creator | Silva A.M. | |
dc.creator | Velloso L.A. | |
dc.creator | Munoz D.P. | |
dc.creator | Ferreira S.T. | |
dc.creator | De Felice F.G. | |
dc.date | 2013 | |
dc.date | 2015-06-25T19:09:06Z | |
dc.date | 2015-11-26T15:07:17Z | |
dc.date | 2015-06-25T19:09:06Z | |
dc.date | 2015-11-26T15:07:17Z | |
dc.date.accessioned | 2018-03-28T22:17:43Z | |
dc.date.available | 2018-03-28T22:17:43Z | |
dc.identifier | | |
dc.identifier | Cell Metabolism. , v. 18, n. 6, p. 831 - 843, 2013. | |
dc.identifier | 15504131 | |
dc.identifier | 10.1016/j.cmet.2013.11.002 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84889656503&partnerID=40&md5=80761e231b5578802dc1a6997571321f | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/88252 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/88252 | |
dc.identifier | 2-s2.0-84889656503 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1257422 | |
dc.description | Alzheimer's disease (AD) and type 2 diabetes appear to share similar pathogenic mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin resistance in metabolic disorders. PKR phosphorylates eukaryotic translation initiation factor 2α (eIF2α-P), and AD brains exhibit elevated phospho-PKR and eIF2α-P levels. Whether and how PKR and eIF2α-P participate in defective brain insulin signaling and cognitive impairment in AD are unknown. We report that β-amyloid oligomers, AD-associated toxins, activate PKR in a tumor necrosis factor α (TNF-α)-dependent manner, resulting in eIF2α-P, neuronal insulin receptor substrate (IRS-1) inhibition, synapse loss, and memory impairment. Brain phospho-PKR and eIF2α-P were elevated in AD animal models, including monkeys given intracerebroventricular oligomer infusions. Oligomers failed to trigger eIF2α-P and cognitive impairment in PKR-/- and TNFR1-/- mice. Bolstering insulin signaling rescued phospho-PKR and eIF2α-P. Results reveal pathogenic mechanisms shared by AD and diabetes and establish that proinflammatory signaling mediates oligomer-induced IRS-1 inhibition and PKR-dependent synapse and memory loss. © 2013 Elsevier Inc. | |
dc.description | 18 | |
dc.description | 6 | |
dc.description | 831 | |
dc.description | 843 | |
dc.description | Bao, F., Wicklund, L., Lacor, P.N., Klein, W.L., Nordberg, A., Marutle, A., Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity (2012) Neurobiol. Aging, 33, pp. 1-e13 | |
dc.description | Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H.L., Born, J., Kern, W., Intranasal insulin improves memory in humans (2004) Psychoneuroendocrinology, 29, pp. 1326-1334 | |
dc.description | Birkenfeld, A.L., Lee, H.Y., Majumdar, S., Jurczak, M.J., Camporez, J.P., Jornayvaz, F.R., Frederick, D.W., Zhang, D., Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism (2011) J. Biol. Chem., 286, pp. 36163-36170 | |
dc.description | Bomfim, T.R., Forny-Germano, L., Sathler, L.B., Brito-Moreira, J., Houzel, J.C., Decker, H., Silverman, M.A., McClean, P.L., An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers (2012) J. Clin. Invest., 122, pp. 1339-1353 | |
dc.description | Bullido, M.J., Martínez-García, A., Tenorio, R., Sastre, I., Muñoz, D.G., Frank, A., Valdivieso, F., Double stranded RNA activated EIF2 α kinase (EIF2AK2 | |
dc.description | PKR) is associated with Alzheimer's disease (2008) Neurobiol. Aging, 29, pp. 1160-1166 | |
dc.description | Chiu, S.-L., Chen, C.-M., Cline, H.T., Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo (2008) Neuron, 58, pp. 708-719 | |
dc.description | Clark, I., Atwood, C., Bowen, R., Paz-Filho, G., Vissel, B., Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales (2012) Pharmacol. Rev., 64, pp. 1004-1026 | |
dc.description | Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, C., Sossin, W., Rosenblum, K., EIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory (2007) Cell, 129, pp. 195-206 | |
dc.description | Craft, S., Baker, L.D., Montine, T.J., Minoshima, S., Watson, G.S., Claxton, A., Arbuckle, M., Plymate, S.R., Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial (2012) Arch. Neurol., 69, pp. 29-38 | |
dc.description | De Felice, F.G., Alzheimer's disease and insulin resistance: Translating basic science into clinical applications (2013) J. Clin. Invest., 123, pp. 531-539 | |
dc.description | De Felice, F.G., Velasco, P.T., Lambert, M.P., Viola, K., Fernandez, S.J., Ferreira, S.T., Klein, W.L., Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine (2007) J. Biol. Chem., 282, pp. 11590-11601 | |
dc.description | De Felice, F.G., Wu, D., Lambert, M.P., Fernandez, S.J., Velasco, P.T., Lacor, P.N., Bigio, E.H., Shughrue, P.J., Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers (2008) Neurobiol. Aging, 29, pp. 1334-1347 | |
dc.description | De Felice, F.G., Vieira, M.N.N., Bomfim, T.R., Decker, H., Velasco, P.T., Lambert, M.P., Viola, K.L., Klein, W.L., Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 1971-1976 | |
dc.description | De La Monte, S.M., Wands, J.R., Alzheimer's disease is type 3 diabetes-evidence reviewed (2008) J. Diabetes Sci. Tech., 2, pp. 1101-1113 | |
dc.description | Ferreira, S.T., Klein, W.L., The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease (2011) Neurobiol. Learn. Mem., 96, pp. 529-543 | |
dc.description | Figueiredo, C.P., Clarke, J.R., Ledo, J.H., Ribeiro, F.C., Costa, C.V., Melo, H.M., Mota-Sales, A.P., Sebollela, A., Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers (2013) J. Neurosci., 33, pp. 9626-9634 | |
dc.description | Gkogkas, C., Sonenberg, N., Costa-Mattioli, M., Translational control mechanisms in long-lasting synaptic plasticity and memory (2010) J. Biol. Chem., 285, pp. 31913-31917 | |
dc.description | Gong, Y., Chang, L., Viola, K.L., Lacor, P.N., Lambert, M.P., Finch, C.E., Krafft, G.A., Klein, W.L., Alzheimer's disease-affected brain: Presence of oligomeric A β ligands (ADDLs) suggests a molecular basis for reversible memory loss (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 10417-10422 | |
dc.description | Gregor, M.F., Hotamisligil, G.S., Inflammatory mechanisms in obesity (2011) Annu. Rev. Immunol., 29, pp. 415-445 | |
dc.description | He, P., Zhong, Z., Lindholm, K., Berning, L., Lee, W., Lemere, C., Staufenbiel, M., Shen, Y., Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice (2007) J. Cell Biol., 178, pp. 829-841 | |
dc.description | Hoozemans, J.J.M., Veerhuis, R., Van Haastert, E.S., Rozemuller, J.M., Baas, F., Eikelenboom, P., Scheper, W., The unfolded protein response is activated in Alzheimer's disease (2005) Acta Neuropathol., 110, pp. 165-172 | |
dc.description | Hoozemans, J.J.M., Van Haastert, E.S., Nijholt, D.A.T., Rozemuller, A.J.M., Eikelenboom, P., Scheper, W., The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus (2009) Am. J. Pathol., 174, pp. 1241-1251 | |
dc.description | Hotamisligil, G.S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease (2010) Cell, 140, pp. 900-917 | |
dc.description | Hotamisligil, G.S., Budavari, A., Murray, D., Spiegelman, B.M., Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α (1994) J. Clin. Invest., 94, pp. 1543-1549 | |
dc.description | Hotamisligil, G.S., Peraldi, P., Budavari, A., Ellis, R., White, M.F., Spiegelman, B.M., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance (1996) Science, 271, pp. 665-668 | |
dc.description | Jankowsky, J.L., Slunt, H.H., Ratovitski, T., Jenkins, N.A., Copeland, N.G., Borchelt, D.R., Co-expression of multiple transgenes in mouse CNS: A comparison of strategies (2001) Biomol. Eng., 17, pp. 157-165 | |
dc.description | Janson, J., Laedtke, T., Parisi, J.E., O'Brien, P.O., Petersen, R.C., Butler, P.C., Increased risk of type 2 diabetes in Alzheimer disease (2004) Diabetes, 53, pp. 474-481 | |
dc.description | Lacor, P.N., Buniel, M.C., Furlow, P.W., Clemente, A.S., Velasco, P.T., Wood, M., Viola, K.L., Klein, W.L., Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease (2007) J. Neurosci., 27, pp. 796-807 | |
dc.description | Lai, E., Teodoro, T., Volchuk, A., Endoplasmic reticulum stress: Signaling the unfolded protein response (2007) Physiology (Bethesda), 22, pp. 193-201 | |
dc.description | Ledo, J.H., Azevedo, E.P., Clarke, J.R., Ribeiro, F.C., Figueiredo, C.P., Foguel, D., De Felice, F.G., Ferreira, S.T., Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice (2013) Mol. Psychiatry, 18, pp. 1053-1054 | |
dc.description | Li, Y., Duffy, K.B., Ottinger, M.A., Ray, B., Bailey, J.A., Holloway, H.W., Tweedie, D., Kapogiannis, D., GLP-1 receptor stimulation reduces amyloid-β peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease (2010) J. Alzheimers Dis., 19, pp. 1205-1219 | |
dc.description | Ma, Q.L., Yang, F., Rosario, E.R., Ubeda, O.J., Beech, W., Gant, D.J., Chen, P.P., Zhao, Y., β-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: Suppression by omega-3 fatty acids and curcumin (2009) J. Neurosci., 29, pp. 9078-9089 | |
dc.description | Ma, T., Trinh, M.A., Wexler, A.J., Bourbon, C., Gatti, E., Pierre, P., Cavener, D.R., Klann, E., Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits (2013) Nat. Neurosci., 16, pp. 1299-1305 | |
dc.description | Mattson, M.P., ER calcium and Alzheimer's disease: In a state of flux (2010) Sci. Signal., 3, p. 10 | |
dc.description | McClean, P.L., Parthsarathy, V., Faivre, E., Hölscher, C., The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease (2011) J. Neurosci., 31, pp. 6587-6594 | |
dc.description | McNay, E.C., Recknagel, A.K., Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes (2011) Neurobiol. Learn. Mem., 96, pp. 432-442 | |
dc.description | Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R., O'Neill, C., Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling (2010) Neurobiol. Aging, 31, pp. 224-243 | |
dc.description | Moreno, J.A., Radford, H., Peretti, D., Steinert, J.R., Verity, N., Martin, M.G., Halliday, M., Ortori, C.A., Sustained translational repression by eIF2α-P mediates prion neurodegeneration (2012) Nature, 485, pp. 507-511 | |
dc.description | Nakamura, T., Furuhashi, M., Li, P., Cao, H., Tuncman, G., Sonenberg, N., Gorgun, C.Z., Hotamisligil, G.S., Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis (2010) Cell, 140, pp. 338-348 | |
dc.description | Nisticò, R., Cavallucci, V., Piccinin, S., Macrì, S., Pignatelli, M., Mehdawy, B., Blandini, F., D'Amelio, M., Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase LTP and recognition memory (2012) Neuromolecular Med., 14, pp. 262-269 | |
dc.description | O'Connor, T., Sadleir, K.R., Maus, E., Velliquette, R.A., Zhao, J., Cole, S.L., Eimer, W.A., Lammich, S., Phosphorylation of the translation initiation factor eIF2α increases BACE1 levels and promotes amyloidogenesis (2008) Neuron, 60, pp. 988-1009 | |
dc.description | Ott, A., Stolk, R.P., Hofman, A., Van Harskamp, F., Grobbee, D.E., Breteler, M.M.B., Association of diabetes mellitus and dementia: The Rotterdam Study (1996) Diabetologia, 39, pp. 1392-1397 | |
dc.description | Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., Tuncman, G., Hotamisligil, G.S., Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes (2004) Science, 306, pp. 457-461 | |
dc.description | Ozcan, U., Yilmaz, E., Ozcan, L., Furuhashi, M., Vaillancourt, E., Smith, R.O., Görgün, C.Z., Hotamisligil, G.S., Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes (2006) Science, 313, pp. 1137-1140 | |
dc.description | Park, S.W., Zhou, Y., Lee, J., Lu, A., Sun, C., Chung, J., Ueki, K., Ozcan, U., The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation (2010) Nat. Med., 16, pp. 429-437 | |
dc.description | Paula-Lima, A.C., Adasme, T., Sanmartín, C., Sebollela, A., Hetz, C., Carrasco, M.A., Ferreira, S.T., Hidalgo, C., Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF (2011) Antioxid. Redox Signal., 14, pp. 1209-1223 | |
dc.description | Pfeffer, K., Matsuyama, T., Kündig, T.M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Mak, T.W., Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. Monocytogenes infection (1993) Cell, 73, pp. 457-467 | |
dc.description | Raven, J.F., Koromilas, A.E., PERK and PKR: Old kinases learn new tricks (2008) Cell Cycle, 7, pp. 1146-1150 | |
dc.description | Reger, M.A., Watson, G.S., Frey II, W.H., Baker, L.D., Cholerton, B., Keeling, M.L., Belongia, D.A., Schellenberg, G.D., Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype (2006) Neurobiol. Aging, 27, pp. 451-458 | |
dc.description | Ryan, G.J., Hardy, Y., Liraglutide: Once-daily GLP-1 agonist for the treatment of type 2 diabetes (2011) J. Clin. Pharm. Ther., 36, pp. 260-274 | |
dc.description | Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Küstermann, E., Role for neuronal insulin resistance in neurodegenerative diseases (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 3100-3105 | |
dc.description | Sebollela, A., Freitas-Correa, L., Oliveira, F.F., Paula-Lima, A.C., Saraiva, L.M., Martins, S.M., Mota, L.D., De Souza, J.M., Amyloid-β oligomers induce differential gene expression in adult human brain slices (2012) J. Biol. Chem., 287, pp. 7436-7445 | |
dc.description | Steinberg, G.R., Michell, B.J., Van Denderen, B.J.W., Watt, M.J., Carey, A.L., Fam, B.C., Andrikopoulos, S., Carling, D., Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling (2006) Cell Metab., 4, pp. 465-474 | |
dc.description | Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Fuino, R.L., Wilson, R.S., Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline (2012) J. Clin. Invest., 122, pp. 1316-1338 | |
dc.description | Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., Deteresa, R., Hill, R., Hansen, L.A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment (1991) Ann. Neurol., 30, pp. 572-580 | |
dc.description | Tomiyama, T., Matsuyama, S., Iso, H., Umeda, T., Takuma, H., Ohnishi, K., Ishibashi, K., Yamashita, T., A mouse model of amyloid β oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo (2010) J. Neurosci., 30, pp. 4845-4856 | |
dc.description | Van Der Heide, L.P., Kamal, A., Artola, A., Gispen, W.H., Ramakers, G.M.J., Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner (2005) J. Neurochem., 94, pp. 1158-1166 | |
dc.description | Winnay, J.N., Boucher, J., Mori, M.A., Ueki, K., Kahn, C.R., A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response (2010) Nat. Med., 16, pp. 438-445 | |
dc.description | Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., Holzenberger, M., Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation (2013) Aging Cell, , 10.1111/acel.12145 Published online July 30, 2013 | |
dc.description | Yang, Y.L., Reis, L.F., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B.R., Weissmann, C., Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase (1995) EMBO J., 14, pp. 6095-6106 | |
dc.description | Yoon, S.O., Park, D.J., Ryu, J.C., Ozer, H.G., Tep, C., Shin, Y.J., Lim, T.H., Walton, J.C., JNK3 perpetuates metabolic stress induced by Aβ peptides (2012) Neuron, 75, pp. 824-837 | |
dc.description | Yusta, B., Baggio, L.L., Estall, J.L., Koehler, J.A., Holland, D.P., Li, H., Pipeleers, D., Drucker, D.J., GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress (2006) Cell Metab., 4, pp. 391-406 | |
dc.description | Zhao, W.Q., De Felice, F.G., Fernandez, S., Chen, H., Lambert, M.P., Quon, M.J., Krafft, G.A., Klein, W.L., Amyloid beta oligomers induce impairment of neuronal insulin receptors (2008) FASEB J., 22, pp. 246-260 | |
dc.description | Zhu, P.J., Huang, W., Kalikulov, D., Yoo, J.W., Placzek, A.N., Stoica, L., Zhou, H., Krnjević, K., Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition (2011) Cell, 147, pp. 1384-1396 | |
dc.language | en | |
dc.publisher | | |
dc.relation | Cell Metabolism | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Tnf-α Mediates Pkr-dependent Memory Impairment And Brain Irs-1 Inhibition Induced By Alzheimer's β-amyloid Oligomers In Mice And Monkeys | |
dc.type | Artículos de revistas | |