dc.creator | Pimentel G.D. | |
dc.creator | Ganeshan K. | |
dc.creator | Carvalheira J.B.C. | |
dc.date | 2014 | |
dc.date | 2015-06-25T18:03:20Z | |
dc.date | 2015-11-26T15:05:47Z | |
dc.date | 2015-06-25T18:03:20Z | |
dc.date | 2015-11-26T15:05:47Z | |
dc.date.accessioned | 2018-03-28T22:16:21Z | |
dc.date.available | 2018-03-28T22:16:21Z | |
dc.identifier | | |
dc.identifier | Molecular And Cellular Endocrinology. Elsevier Ireland Ltd, v. 397, n. 01/02/15, p. 15 - 22, 2014. | |
dc.identifier | 3037207 | |
dc.identifier | 10.1016/j.mce.2014.06.005 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84914163652&partnerID=40&md5=994361ed888f4192af4ec40a56959e57 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/88024 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/88024 | |
dc.identifier | 2-s2.0-84914163652 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1257111 | |
dc.description | The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states. | |
dc.description | 397 | |
dc.description | 01/02/15 | |
dc.description | 15 | |
dc.description | 22 | |
dc.description | Anand, B.K., Brobeck, J.R., Hypothalamic control of food intake in rats and cats (1951) Yale J. Biol. Med, 24, pp. 123-140 | |
dc.description | Arkan, M.C., Hevener, A.L., Greten, F.R., Maeda, S., Li, Z.W., Long, J.M., IKK-beta links inflammation to obesity-induced insulin resistance (2005) Nat. Med, 11, pp. 191-198 | |
dc.description | Arruda, A.P., Milanski, M., Coope, A., Torsoni, A.S., Ropelle, E., Carvalho, D.P., Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion (2011) Endocrinology, 152, pp. 1314-1326 | |
dc.description | Bernard, C., Leçons de physiologie expérimentale appliqupée à la mpédecine: faites au collège de France (1854), Tome I, Cours du semestre d'hiver, Paris, J.-B. BaillièreBjorbaek, C., Uotani, S., da Silva, B., Flier, J.S., Divergent signaling capacities of the long and short isoforms of the leptin receptor (1997) J. Biol. Chem, 272, pp. 32686-32695 | |
dc.description | Bjorbaek, C., Buchholz, R.M., Davis, S.M., Bates, S.H., Pierroz, D.D., Gu, H., Divergent roles of SHP-2 in ERK activation by leptin receptors (2001) J. Biol. Chem, 276, pp. 4747-4755 | |
dc.description | Bjorbak, C., Lavery, H.J., Bates, S.H., Olson, R.K., Davis, S.M., Flier, J.S., SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 (2000) J. Biol. Chem, 275, pp. 40649-40657 | |
dc.description | Bode, J.G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages (1999) FEBS Lett, 463, pp. 365-370 | |
dc.description | Bruning, J.C., Gautam, D., Burks, D.J., Gillette, J., Schubert, M., Orban, P.C., Role of brain insulin receptor in control of body weight and reproduction (2000) Science, 289, pp. 2122-2125 | |
dc.description | Cai, D., Yuan, M., Frantz, D.F., Melendez, P.A., Hansen, L., Lee, J., Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB (2005) Nat. Med, 11, pp. 183-190 | |
dc.description | Calegari, V.C., Torsoni, A.S., Vanzela, E.C., Araujo, E.P., Morari, J., Zoppi, C.C., Inflammation of the hypothalamus leads to defective pancreatic islet function (2011) J. Biol. Chem, 286, pp. 12870-12880 | |
dc.description | Cao, L., Liu, X., Lin, E.J., Wang, C., Choi, E.Y., Riban, V., Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition (2010) Cell, 142, pp. 52-64 | |
dc.description | Caricilli, A.M., Picardi, P.K., de Abreu, L.L., Ueno, M., Prada, P.O., Ropelle, E.R., Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice (2011) PLoS Biol, 9, p. e1001212 | |
dc.description | Carvalheira, J.B., Siloto, R.M., Ignacchitti, I., Brenelli, S.L., Carvalho, C.R., Leite, A., Insulin modulates leptin-induced STAT3 activation in rat hypothalamus (2001) FEBS Lett, 500, pp. 119-124 | |
dc.description | Carvalheira, J.B., Ribeiro, E.B., Araujo, E.P., Guimaraes, R.B., Telles, M.M., Torsoni, M., Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats (2003) Diabetologia, 46, pp. 1629-1640 | |
dc.description | Carvalheira, J.B., Torsoni, M.A., Ueno, M., Amaral, M.E., Araujo, E.P., Velloso, L.A., Cross-talk between the insulin and leptin signaling systems in rat hypothalamus (2005) Obes. Res, 13, pp. 48-57 | |
dc.description | Carvalheira, J.B., Qiu, Y., Chawla, A., Blood spotlight on leukocytes and obesity (2013) Blood, 122, pp. 3263-3267 | |
dc.description | Carvalho-Filho, M.A., Ueno, M., Hirabara, S.M., Seabra, A.B., Carvalheira, J.B., de Oliveira, M.G., S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance (2005) Diabetes, 54, pp. 959-967 | |
dc.description | Chakravarthy, M.V., Zhu, Y., Yin, L., Coleman, T., Pappan, K.L., Marshall, C.A., Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation (2009) J. Lipid Res, 50, pp. 630-640 | |
dc.description | Coleman, D.L., Effects of parabiosis of obese with diabetes and normal mice (1973) Diabetologia, 9, pp. 294-298 | |
dc.description | Coleman, D.L., Hummel, K.P., The influence of genetic background on the expression of the obese (Ob) gene in the mouse (1973) Diabetologia, 9, pp. 287-293 | |
dc.description | Cota, D., Proulx, K., Smith, K.A., Kozma, S.C., Thomas, G., Woods, S.C., Hypothalamic mTOR signaling regulates food intake (2006) Science, 312, pp. 927-930 | |
dc.description | Dagon, Y., Hur, E., Zheng, B., Wellenstein, K., Cantley, L.C., Kahn, B.B., P70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake (2012) Cell Metab, 16, pp. 104-112 | |
dc.description | De Souza, C.T., Araujo, E.P., Bordin, S., Ashimine, R., Zollner, R.L., Boschero, A.C., Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus (2005) Endocrinology, 146, pp. 4192-4199 | |
dc.description | DeBoer, M.D., Zhu, X.X., Levasseur, P., Meguid, M.M., Suzuki, S., Inui, A., Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia (2007) Endocrinology, 148, pp. 3004-3012 | |
dc.description | Ehlting, C., Lai, W.S., Schaper, F., Brenndorfer, E.D., Matthes, R.J., Heinrich, P.C., Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade (2007) J. Immunol, 178, pp. 2813-2826 | |
dc.description | Ehses, J.A., Meier, D.T., Wueest, S., Rytka, J., Boller, S., Wielinga, P.Y., Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet (2010) Diabetologia, 53, pp. 1795-1806 | |
dc.description | Emanuelli, B., Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D.J., SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice (2001) J. Biol. Chem, 276, pp. 47944-47949 | |
dc.description | Erin, N., Duymus, O., Ozturk, S., Demir, N., Activation of vagus nerve by semapimod alters substance P levels and decreases breast cancer metastasis (2012) Regul. Pept, 179, pp. 101-108 | |
dc.description | Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo (2013) Cell Metab, 17, pp. 113-124 | |
dc.description | Ferrante, A.W., Obesity-induced inflammation: a metabolic dialogue in the language of inflammation (2007) J. Int. Med, 262, pp. 408-414 | |
dc.description | Flores, M.B., Rocha, G.Z., Damas-Souza, D.M., Osorio-Costa, F., Dias, M.M., Ropelle, E.R., Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice (2012) Gastroenterology, 143 (53-741), pp. e1-e4 | |
dc.description | Foster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol. Med, 9, pp. 160-168 | |
dc.description | Gelin, J., Moldawer, L.L., Lonnroth, C., Sherry, B., Chizzonite, R., Lundholm, K., Role of endogenous tumor necrosis factor alpha and interleukin 1 for experimental tumor growth and the development of cancer cachexia (1991) Cancer Res, 51, pp. 415-421 | |
dc.description | Ghilardi, N., Skoda, R.C., The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line (1997) Mol. Endocrinol, 11, pp. 393-399 | |
dc.description | Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M.H., Skoda, R.C., Defective STAT signaling by the leptin receptor in diabetic mice (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 6231-6235 | |
dc.description | Han, M.S., Jung, D.Y., Morel, C., Lakhani, S.A., Kim, J.K., Flavell, R.A., JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation (2013) Science, 339, pp. 218-222 | |
dc.description | Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation (2011) Cell, 144, pp. 646-674 | |
dc.description | Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: a nutrient and energy sensor that maintains energy homeostasis (2012) Nat. Rev. Mol. Cell Biol, 13, pp. 251-262 | |
dc.description | Haslett, P.A., Anticytokine approaches to the treatment of anorexia and cachexia (1998) Semin. Oncol, 25, pp. 53-57 | |
dc.description | Hervey, G.R., The effects of lesions in the hypothalamus in parabiotic rats (1959) J. Physiol, 145, pp. 336-352 | |
dc.description | Heymsfield, S.B., Greenberg, A.S., Fujioka, K., Dixon, R.M., Kushner, R., Hunt, T., Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial (1999) JAMA, 282, pp. 1568-1575 | |
dc.description | Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C.Z., Uysal, K.T., Maeda, K., A central role for JNK in obesity and insulin resistance (2002) Nature, 420, pp. 333-336 | |
dc.description | Holzer, R.G., Park, E.J., Li, N., Tran, H., Chen, M., Choi, C., Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation (2011) Cell, 147, pp. 173-184 | |
dc.description | Hopkins, S.J., Rothwell, N.J., Cytokines and the nervous system. I: Expression and recognition (1995) Trends Neurosci, 18, pp. 83-88 | |
dc.description | Hossain, P., Kawar, B., El Nahas, M., Obesity and diabetes in the developing world-a growing challenge (2007) N Eng. J. Med, 356, pp. 213-215 | |
dc.description | Hotamisligil, G.S., Inflammation and metabolic disorders (2006) Nature, 444, pp. 860-867 | |
dc.description | Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance (1993) Science, 259, pp. 87-91 | |
dc.description | Inoki, K., Zhu, T., Guan, K.L., TSC2 mediates cellular energy response to control cell growth and survival (2003) Cell, 115, pp. 577-590 | |
dc.description | Iyer, A., Fairlie, D.P., Prins, J.B., Hammock, B.D., Brown, L., Inflammatory lipid mediators in adipocyte function and obesity (2010) Nat. Rev. Endocrinol, 6, pp. 71-82 | |
dc.description | Kellerer, M., Koch, M., Metzinger, E., Mushack, J., Capp, E., Haring, H.U., Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways (1997) Diabetologia, 40, pp. 1358-1362 | |
dc.description | Kiba, T., Tanaka, K., Endo, O., Inoue, S., Role of vagus nerve in increased DNA synthesis after hypothalamic ventromedial lesions in rat liver (1992) Am. J. Physiol, 262. , G483-7 | |
dc.description | Kievit, P., Howard, J.K., Badman, M.K., Balthasar, N., Coppari, R., Mori, H., Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells (2006) Cell Metab, 4, pp. 123-132 | |
dc.description | Konner, A.C., Bruning, J.C., Selective insulin and leptin resistance in metabolic disorders (2012) Cell Metab, 16, pp. 144-152 | |
dc.description | Lage, R., Dieguez, C., Vidal-Puig, A., Lopez, M., AMPK: a metabolic gauge regulating whole-body energy homeostasis (2008) Trends Mol. Med, 14, pp. 539-549 | |
dc.description | Laviano, A., Gleason, J.R., Meguid, M.M., Yang, Z.J., Cangiano, C., Rossi Fanelli, F., Effects of intra-VMN mianserin and IL-1ra on meal number in anorectic tumor-bearing rats (2000) J. Invest. Med, 48, pp. 40-48 | |
dc.description | Laviano, A., Meguid, M.M., Rossi-Fanelli, F., Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies (2003) Lancet Oncol, 4, pp. 686-694 | |
dc.description | Lee, E.Y., Inoue, S., Senoo, A., Shimizu, H., Suzuki, Y., Ishizuka, N., Beneficial effects of ventromedial hypothalamus (VMH) lesioning on function and morphology of the liver after hepatectomy in rats (2011) Brain Res, 1421, pp. 82-89 | |
dc.description | Licinio, J., Wong, M.L., Pathways and mechanisms for cytokine signaling of the central nervous system (1997) J. Clin. Invest, 100, pp. 2941-2947 | |
dc.description | Lira, F.S., Yamashita, A.S., Rosa, J.C., Tavares, F.L., Caperuto, E., Carnevali, L.C., Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats (2011) Nutr. Metab (Lond)., 8, p. 60 | |
dc.description | Liu, X., McMurphy, T., Xiao, R., Slater, A., Huang, W., Cao, L., Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice (2014) Mol. Ther | |
dc.description | Lopez, M., Lage, R., Saha, A.K., Perez-Tilve, D., Vazquez, M.J., Varela, L., Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin (2008) Cell Metab, 7, pp. 389-399 | |
dc.description | Lopez, M., Varela, L., Vazquez, M.J., Rodriguez-Cuenca, S., Gonzalez, C.R., Velagapudi, V.R., Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance (2010) Nat. Med, 16, pp. 1001-1008 | |
dc.description | Lumeng, C.N., Bodzin, J.L., Saltiel, A.R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization (2007) J. Clin. Invest, 117, pp. 175-184 | |
dc.description | Mantovani, G., Maccio, A., Lai, P., Massa, E., Ghiani, M., Santona, M.C., Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (1998) Semin. Oncol, 25, pp. 45-52 | |
dc.description | Marshall, H.E., Hess, D.T., Stamler, J.S., S-nitrosylation: physiological regulation of NF-kappaB (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 8841-8842 | |
dc.description | de Martinez Morentin, P.B., Martinez-Sanchez, N., Roa, J., Ferno, J., Nogueiras, R., Tena-Sempere, M., Hypothalamic mTOR: the rookie energy sensor (2014) Curr. Mol. Med, 14, pp. 3-21 | |
dc.description | Martins, L., Fernandez-Mallo, D., Novelle, M.G., Vazquez, M.J., Tena-Sempere, M., Nogueiras, R., Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin (2012) PLoS ONE, 7, p. e46923 | |
dc.description | Matthys, P., Billiau, A., Cytokines and cachexia (1997) Nutrition, 13, pp. 763-770 | |
dc.description | Mayer, C.M., Belsham, D.D., Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation (2010) Endocrinology, 151, pp. 576-585 | |
dc.description | McNay, D.E., Briancon, N., Kokoeva, M.V., Maratos-Flier, E., Flier, J.S., Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice (2012) J. Clin. Invest, 122, pp. 142-152 | |
dc.description | Medzhitov, R., Origin and physiological roles of inflammation (2008) Nature, 454, pp. 428-435 | |
dc.description | Meng, Q., Cai, D., Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway (2011) J. Biol. Chem, 286, pp. 32324-32332 | |
dc.description | Mercer, J.G., Hoggard, N., Williams, L.M., Lawrence, C.B., Hannah, L.T., Trayhurn, P., Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization (1996) FEBS Lett, 387, pp. 113-116 | |
dc.description | Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D.E., Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity (2009) J. Neurosci, 29, pp. 359-370 | |
dc.description | Milanski, M., Arruda, A.P., Coope, A., Ignacio-Souza, L.M., Nunez, C.E., Roman, E.A., Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver (2012) Diabetes, 61, pp. 1455-1462 | |
dc.description | Miller, N.E., Experiments on motivation. Studies combining psychological, physiological, and pharmacological techniques (1957) Science, 126, pp. 1271-1278 | |
dc.description | Moldawer, L.L., Rogy, M.A., Lowry, S.F., The role of cytokines in cancer cachexia (1992) JPEN J. Parenter Enteral Nutr, 16, pp. 43S-49S | |
dc.description | Moraes, J.C., Coope, A., Morari, J., Cintra, D.E., Roman, E.A., Pauli, J.R., High-fat diet induces apoptosis of hypothalamic neurons (2009) PLoS ONE, 4, p. e5045 | |
dc.description | Myers, M.G., Cowley, M.A., Munzberg, H., Mechanisms of leptin action and leptin resistance (2008) Annu. Rev. Physiol, 70, pp. 537-556 | |
dc.description | Myers, M.G., Leibel, R.L., Seeley, R.J., Schwartz, M.W., Obesity and leptin resistance: distinguishing cause from effect (2010) Trends Endocrinol. Metab, 21, pp. 643-651 | |
dc.description | Nakamura, T., Furuhashi, M., Li, P., Cao, H., Tuncman, G., Sonenberg, N., Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis (2010) Cell, 140, pp. 338-348 | |
dc.description | Nathan, C., Ding, A., Nonresolving inflammation (2010) Cell, 140, pp. 871-882 | |
dc.description | Nguyen, M.T., Favelyukis, S., Nguyen, A.K., Reichart, D., Scott, P.A., Jenn, A., A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways (2007) J. Biol. Chem, 282, pp. 35279-35292 | |
dc.description | Nguyen, K.D., Qiu, Y., Cui, X., Goh, Y.P., Mwangi, J., David, T., Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis (2011) Nature, 480, pp. 104-108 | |
dc.description | Niswender, K.D., Baskin, D.G., Schwartz, M.W., Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis (2004) Trends Endocrinol. Metab, 15, pp. 362-369 | |
dc.description | Noguchi, Y., Yoshikawa, T., Matsumoto, A., Svaninger, G., Gelin, J., Are cytokines possible mediators of cancer cachexia? (1996) Surg. Today, 26, pp. 467-475 | |
dc.description | Odegaard, J.I., Chawla, A., Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis (2013) Science, 339, pp. 172-177 | |
dc.description | Odegaard, J.I., Chawla, A., The immune system as a sensor of the metabolic state (2013) Immunity, 38, pp. 644-654 | |
dc.description | Okin, D., Medzhitov, R., Evolution of inflammatory diseases (2012) Curr. Biol, 22, pp. R733-R740 | |
dc.description | Olefsky, J.M., Glass, C.K., Macrophages, inflammation, and insulin resistance (2010) Annu. Rev. Physiol, 72, pp. 219-246 | |
dc.description | O'Neill, L.A., Hardie, D.G., Metabolism of inflammation limited by AMPK and pseudo-starvation (2013) Nature, 493, pp. 346-355 | |
dc.description | Osório-Costa, F., Carvalheira, J.C., TNF-α in obesity-associated colon cancer (2013) Trans. Gastrointest. Cancer, 2 (4), pp. 179-193. , 2, 15 | |
dc.description | Pal, A., Barber, T.M., Van de Bunt, M., Rudge, S.A., Zhang, Q., Lachlan, K.L., PTEN mutations as a cause of constitutive insulin sensitivity and obesity (2012) N Eng. J. Med, 367, pp. 1002-1011 | |
dc.description | Park, E.J., Lee, J.H., Yu, G.Y., He, G., Ali, S.R., Holzer, R.G., Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression (2010) Cell, 140, pp. 197-208 | |
dc.description | Phillips, M.S., Liu, Q., Hammond, H.A., Dugan, V., Hey, P.J., Caskey, C.J., Leptin receptor missense mutation in the fatty Zucker rat (1996) Nat. Genet, 13, pp. 18-19 | |
dc.description | Pimentel, G.D., Lira, F.S., Rosa, J.C., Oliveira, J.L., Losinskas-Hachul, A.C., Souza, G.I., Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFkappaBp65 signaling in adult offspring (2012) J. Nutr. Biochem, 23, pp. 265-271 | |
dc.description | Posey, K.A., Clegg, D.J., Printz, R.L., Byun, J., Morton, G.J., Vivekanandan-Giri, A., Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet (2009) Am. J. Physiol. Endocrinol. Metab, 296. , E1003-12 | |
dc.description | Prada, P.O., Zecchin, H.G., Gasparetti, A.L., Torsoni, M.A., Ueno, M., Hirata, A.E., (2005), 146, pp. 1576-1587Purkayastha, S., Zhang, G., Cai, D., Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB (2011) Nat. Med, 17, pp. 883-887 | |
dc.description | Radley-Crabb, H.G., Marini, J.C., Sosa, H.A., Castillo, L.I., Grounds, M.D., Fiorotto, M.L., Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy (2014) PLoS ONE, 9, p. e89277 | |
dc.description | Ranson, S.W., Fisher, C., Ingram, W.R., Adiposity and diabetes mellitus in a monkey with hypothalamic lesions (1938) Endocrinology, 23, pp. 175-181 | |
dc.description | Reynaert, N.L., Ckless, K., Korn, S.H., Vos, N., Guala, A.S., Wouters, E.F., Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 8945-8950 | |
dc.description | Ropelle, E.R., Pauli, J.R., Zecchin, K.G., Ueno, M., de Souza, C.T., Morari, J., A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia (2007) Endocrinology, 148, pp. 5220-5229 | |
dc.description | Ropelle, E.R., Pauli, J.R., Fernandes, M.F., Rocco, S.A., Marin, R.M., Morari, J., A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss (2008) Diabetes, 57, pp. 594-605 | |
dc.description | Ropelle, E.R., Flores, M.B., Cintra, D.E., Rocha, G.Z., Pauli, J.R., Morari, J., IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition (2010) PLoS Biol, 8, p. e1000465 | |
dc.description | Ropelle, E.R., Pauli, J.R., Cintra, D.E., da Silva, A.S., De Souza, C.T., Guadagnini, D., Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice (2013) Diabetes, 62, pp. 466-470 | |
dc.description | Rother, E., Kuschewski, R., Alcazar, M.A., Oberthuer, A., Bae-Gartz, I., Vohlen, C., Hypothalamic JNK1 and IKKbeta activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding (2012) Endocrinology, 153, pp. 770-781 | |
dc.description | Rothwell, N.J., Hopkins, S.J., Cytokines and the nervous system II: Actions and mechanisms of action (1995) Trends Neurosci, 18, pp. 130-136 | |
dc.description | Saberi, M., Woods, N.B., de Luca, C., Schenk, S., Lu, J.C., Bandyopadhyay, G., Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice (2009) Cell Metab, 10, pp. 419-429 | |
dc.description | Saper, C.B., Romanovsky, A.A., Scammell, T.E., Neural circuitry engaged by prostaglandins during the sickness syndrome (2012) Nat. Neurosci, 15, pp. 1088-1095 | |
dc.description | Scarlett, J.M., Jobst, E.E., Enriori, P.J., Bowe, D.D., Batra, A.K., Grant, W.F., Regulation of central melanocortin signaling by interleukin-1 beta (2007) Endocrinology, 148, pp. 4217-4225 | |
dc.description | Schneider, J.G., Finck, B.N., Ren, J., Standley, K.N., Takagi, M., Maclean, K.H., ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome (2006) Cell Metab, 4, pp. 377-389 | |
dc.description | Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P., Baskin, D.G., Identification of targets of leptin action in rat hypothalamus (1996) J. Clin. Invest, 98, pp. 1101-1106 | |
dc.description | Scrivo, R., Vasile, M., Bartosiewicz, I., Valesini, G., Inflammation as "common soil" of the multifactorial diseases (2011) Autoimmun. Rev, 10, pp. 369-374 | |
dc.description | Sell, H., Habich, C., Eckel, J., Adaptive immunity in obesity and insulin resistance (2012) Nat. Rev. Endocrinol, 8, pp. 709-716 | |
dc.description | Senn, J.J., Klover, P.J., Nowak, I.A., Zimmers, T.A., Koniaris, L.G., Furlanetto, R.W., Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes (2003) J. Biol. Chem, 278, pp. 13740-13746 | |
dc.description | Sherry, B.A., Gelin, J., Fong, Y., Marano, M., Wei, H., Cerami, A., Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models (1989) Faseb J., 3, pp. 1956-1962 | |
dc.description | Shi, H., Tzameli, I., Bjorbaek, C., Flier, J.S., Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling (2004) J. Biol. Chem, 279, pp. 34733-34740 | |
dc.description | Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., Flier, J.S., TLR4 links innate immunity and fatty acid-induced insulin resistance (2006) J. Clin. Invest, 116, pp. 3015-3025 | |
dc.description | Solinas, G., Vilcu, C., Neels, J.G., Bandyopadhyay, G.K., Luo, J.L., Naugler, W., JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity (2007) Cell Metab, 6, pp. 386-397 | |
dc.description | Speakman, J.R., A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis (2007) Cell Metab, 6, pp. 5-12 | |
dc.description | Stamler, J.S., Hess, D.T., Nascent nitrosylases (2010) Nat. Cell Biol, 12, pp. 1024-1026 | |
dc.description | Sternberg, E.M., Neural-immune interactions in health and disease (1997) J. Clin. Invest, 100, pp. 2641-2647 | |
dc.description | Tabas, I., Glass, C.K., Anti-inflammatory therapy in chronic disease: challenges and opportunities (2013) Science, 339, pp. 166-172 | |
dc.description | Takeda, K., Akira, S., TLR signaling pathways (2004) Semin. Immunol, 16, pp. 3-9 | |
dc.description | Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Identification and expression cloning of a leptin receptor, OB-R (1995) Cell, 83, pp. 1263-1271 | |
dc.description | Teitelbaum, P., Stellar, E., Recovery from the failure to eat produced by hypothalamic lesions (1954) Science, 120, pp. 894-895 | |
dc.description | Thaler, J.P., Schwartz, M.W., Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up (2010) Endocrinology, 151, pp. 4109-4115 | |
dc.description | Thaler, J.P., Yi, C.X., Schur, E.A., Guyenet, S.J., Hwang, B.H., Dietrich, M.O., Obesity is associated with hypothalamic injury in rodents and humans (2012) J. Clin. Invest, 122, pp. 153-162 | |
dc.description | Tisdale, M.J., Biology of cachexia (1997) J. Nat. Cancer Inst, 89, pp. 1763-1773 | |
dc.description | Tobias, D.K., Pan, A., Jackson, C.L., O'Reilly, E.J., Ding, E.L., Willett, W.C., Body-mass index and mortality among adults with incident type 2 diabetes (2014) N Eng. J. Med, 370, pp. 233-244 | |
dc.description | Tracey, K.J., The inflammatory reflex (2002) Nature, 420, pp. 853-859 | |
dc.description | Tracey, K.J., Physiology and immunology of the cholinergic antiinflammatory pathway (2007) J. Clin. Invest, 117, pp. 289-296 | |
dc.description | Tsukumo, D.M., Carvalho-Filho, M.A., Carvalheira, J.B., Prada, P.O., Hirabara, S.M., Schenka, A.A., Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance (2007) Diabetes, 56, pp. 1986-1998 | |
dc.description | Ueki, K., Kondo, T., Kahn, C.R., Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms (2004) Mol. Cell Biol, 24, pp. 5434-5446 | |
dc.description | Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Stoffel, M., Friedman, J.M., Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice (1996) Nat. Genet, 14, pp. 95-97 | |
dc.description | Varela, L., Martinez-Sanchez, N., Gallego, R., Vazquez, M.J., Roa, J., Gandara, M., Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism (2012) J. Pathol, 227, pp. 209-222 | |
dc.description | Warburg, O., On the origin of cancer cells (1956) Science, 123, pp. 309-314 | |
dc.description | Weisberg, S.P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R.L., Ferrante, A.W., Obesity is associated with macrophage accumulation in adipose tissue (2003) J. Clin. Invest, 112, pp. 1796-1808 | |
dc.description | Weisberg, S.P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., CCR2 modulates inflammatory and metabolic effects of high-fat feeding (2006) J. Clin. Invest, 116, pp. 115-124 | |
dc.description | Woods, A.J., Stock, M.J., Leptin activation in hypothalamus (1996) Nature, 381, p. 745 | |
dc.description | Woods, S.C., Lotter, E.C., McKay, L.D., Porte, D., Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons (1979) Nature, 282, pp. 503-505 | |
dc.description | Wu, J.J., Roth, R.J., Anderson, E.J., Hong, E.G., Lee, M.K., Choi, C.S., Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity (2006) Cell Metab, 4, pp. 61-73 | |
dc.description | Xu, A.W., Kaelin, C.B., Takeda, K., Akira, S., Schwartz, M.W., Barsh, G.S., PI3K integrates the action of insulin and leptin on hypothalamic neurons (2005) J. Clin. Invest, 115, pp. 951-958 | |
dc.description | Yi, C.X., Al-Massadi, O., Donelan, E., Lehti, M., Weber, J., Ress, C., Exercise protects against high-fat diet-induced hypothalamic inflammation (2012) Physiol. Behav, 106, pp. 485-490 | |
dc.description | Yoshimoto, S., Loo, T.M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome (2013) Nature, 499, pp. 97-101 | |
dc.description | Zabolotny, J.M., Bence-Hanulec, K.K., Stricker-Krongrad, A., Haj, F., Wang, Y., Minokoshi, Y., PTP1B regulates leptin signal transduction in vivo (2002) Dev. Cell, 2, pp. 489-495 | |
dc.description | Zabolotny, J.M., Kim, Y.B., Welsh, L.A., Kershaw, E.E., Neel, B.G., Kahn, B.B., Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo (2008) J. Biol. Chem, 283, pp. 14230-14241 | |
dc.description | Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., Positional cloning of the mouse obese gene and its human homologue (1994) Nature, 372, pp. 425-432 | |
dc.description | Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., Cai, D., Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity (2008) Cell, 135, pp. 61-73 | |
dc.description | Zheng, W., McLerran, D.F., Rolland, B., Zhang, X., Inoue, M., Matsuo, K., Association between body-mass index and risk of death in more than 1 million Asians (2011) N Eng. J. Med, 364, pp. 719-729 | |
dc.language | en | |
dc.publisher | Elsevier Ireland Ltd | |
dc.relation | Molecular and Cellular Endocrinology | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Hypothalamic Inflammation And The Central Nervous System Control Of Energy Homeostasis | |
dc.type | Artículos de revistas | |