The Value Of The 2005 International Society Of Urological Pathology (isup) Modified Gleason Grading System As A Predictor Of Biochemical Recurrence After Radical Prostatectomy

dc.creatorBillis A.
dc.creatorQuintal M.M.Q.
dc.creatorMeirelles L.
dc.creatorFreitas L.L.L.
dc.creatorCosta L.B.E.
dc.creatorBonfitto J.F.L.
dc.creatorDiniz B.L.
dc.creatorPoletto P.H.
dc.creatorMagna L.A.
dc.creatorFerreira U.
dc.date2014
dc.date2015-06-25T18:03:11Z
dc.date2015-11-26T15:05:35Z
dc.date2015-06-25T18:03:11Z
dc.date2015-11-26T15:05:35Z
dc.date.accessioned2018-03-28T22:16:12Z
dc.date.available2018-03-28T22:16:12Z
dc.identifier
dc.identifierInternational Urology And Nephrology. Kluwer Academic Publishers, v. 46, n. 5, p. 935 - 940, 2014.
dc.identifier3011623
dc.identifier10.1007/s11255-013-0579-8
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903648759&partnerID=40&md5=2e420f9564b549e18b76aebc8a254164
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87995
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87995
dc.identifier2-s2.0-84903648759
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257074
dc.descriptionPurpose: To compare time and risk to biochemical recurrence (BR) after radical prostatectomy of two chronologically different groups of patients using the standard and the modified Gleason system (MGS). Methods: Cohort 1 comprised biopsies of 197 patients graded according to the standard Gleason system (SGS) in the period 1997/2004, and cohort 2, 176 biopsies graded according to the modified system in the period 2005/2011. Time to BR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter time to recurrence using univariate and multivariate Cox proportional hazards model. Results: Patients in cohort 2 reflected time-related changes: striking increase in clinical stage T1c, systematic use of extended biopsies, and lower percentage of total length of cancer in millimeter in all cores. The MGS used in cohort 2 showed fewer biopsies with Gleason score ≤6 and more biopsies of the intermediate Gleason score 7. Time to BR using the Kaplan-Meier curves showed statistical significance using the MGS in cohort 2, but not the SGS in cohort 1. Only the MGS predicted shorter time to BR on univariate analysis and on multivariate analysis was an independent predictor. Conclusions: The results favor that the 2005 International Society of Urological Pathology modified system is a refinement of the Gleason grading and valuable for contemporary clinical practice. © Springer Science+Business Media 2013.
dc.description46
dc.description5
dc.description935
dc.description940
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dc.languageen
dc.publisherKluwer Academic Publishers
dc.relationInternational Urology and Nephrology
dc.rightsfechado
dc.sourceScopus
dc.titleThe Value Of The 2005 International Society Of Urological Pathology (isup) Modified Gleason Grading System As A Predictor Of Biochemical Recurrence After Radical Prostatectomy
dc.typeArtículos de revistas


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