Nat2, Xrcc1 And Hogg1 Polymorphisms, Cigarette Smoking, Alcohol Consumption And Risk Of Upper Aerodigestive Tract Cancer

dc.creatorMarques C.R.
dc.creatorDa Silva T.M.
dc.creatorDe Albuquerque D.M.
dc.creatorChaves M.S.
dc.creatorFilho M.F.M.
dc.creatorOliveira J.S.
dc.creatorDi Pietro G.
dc.creatorSousa S.M.B.
dc.creatorSimos A.L.
dc.creatorRios-Santos F.
dc.date2014
dc.date2015-06-25T18:02:51Z
dc.date2015-11-26T15:05:02Z
dc.date2015-06-25T18:02:51Z
dc.date2015-11-26T15:05:02Z
dc.date.accessioned2018-03-28T22:15:50Z
dc.date.available2018-03-28T22:15:50Z
dc.identifier
dc.identifierAnticancer Research. International Institute Of Anticancer Research, v. 34, n. 6, p. 3217 - 3224, 2014.
dc.identifier2507005
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906322745&partnerID=40&md5=5c6fb6a258686a7fd1feb77f949c6f77
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87918
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87918
dc.identifier2-s2.0-84906322745
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256984
dc.descriptionAim: To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair crosscomplementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. Patients and Methods: A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Results: Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among neverdrinkers (p=0.048). Conclusion: Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.
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dc.description3217
dc.description3224
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dc.languageen
dc.publisherInternational Institute of Anticancer Research
dc.relationAnticancer Research
dc.rightsaberto
dc.sourceScopus
dc.titleNat2, Xrcc1 And Hogg1 Polymorphisms, Cigarette Smoking, Alcohol Consumption And Risk Of Upper Aerodigestive Tract Cancer
dc.typeArtículos de revistas


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