Nonfunctional Overreaching Leads To Inflammation And Myostatin Upregulation In Swiss Mice

dc.creatorPereira B.C.
dc.creatorPauli J.R.
dc.creatorDe Souza C.T.
dc.creatorRopelle E.R.
dc.creatorCintra D.E.
dc.creatorRocha E.M.
dc.creatorFreitas E.C.
dc.creatorPapoti M.
dc.creatorDa Silva L.
dc.creatorLira F.S.
dc.creatorDa Silva A.S.R.
dc.date2014
dc.date2015-06-25T18:02:41Z
dc.date2015-11-26T15:04:49Z
dc.date2015-06-25T18:02:41Z
dc.date2015-11-26T15:04:49Z
dc.date.accessioned2018-03-28T22:15:39Z
dc.date.available2018-03-28T22:15:39Z
dc.identifier
dc.identifierInternational Journal Of Sports Medicine. , v. 35, n. 2, p. 139 - 146, 2014.
dc.identifier1724622
dc.identifier10.1055/s-0033-1349077
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84892922501&partnerID=40&md5=162892a5cd97b46f0e2a5938f82d9063
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87883
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87883
dc.identifier2-s2.0-84892922501
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256941
dc.descriptionThe aims of the this study were a) to verify whether the performance decrease induced by nonfunctional overreaching (NFOR) is linked to high concentrations of cytokines in serum, skeletal muscles and liver; b) to verify muscle myostatin adaptation to NFOR; c) to verify the effects of chronic glucose supplementation on the parameters mentioned above. Mice were divided into control (C), trained (TR), overtrained (OTR) and supplemented overtrained (OTR+S). The incremental load test (ILT) and exhaustive test (ET) were used to measure performances before and after exercise protocols. 24 h after ET, muscles and liver were removed and stored at -80°C for subsequent measurements. Total blood was collected from decapitation for subsequent determination of cytokine concentrations. Generally, OTR and OTR+S presented higher contents of IL-6, TNF-alpha, GLUT-4 and myostatin in muscle samples compared to C and TR. Glucose supplementation attenuated the high contents of IL-6, TNF-alpha and IL-15 in liver, and of IL-6 in serum. In summary, NFOR led to low-grade chronic inflammation and myostatin upregulation. © Georg Thieme Verlag KG Stuttgart · New York.
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dc.description2
dc.description139
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dc.descriptionAdser, H., Wojtaszewski, J.F., Jakobsen, A.H., Kiilerich, K., Hidalgo, J., Pilegaard, H., Interleukin-6 modifies mRNA expression in mouse skeletal muscle (2011) Acta Physiol (Oxf), 202, pp. 165-173
dc.descriptionAllen, D.L., Hittel, D.S., McPherron, A.C., Expression and function of myostatin in obesity, diabetes, and exercise adaptation (2011) Med Sci Sports Exerc, 43, pp. 1828-1835
dc.descriptionArmstrong, R.B., Phelps, R.O., Muscle fiber type composition of the rat hindlimb (1984) American Journal of Anatomy, 171 (3), pp. 259-272. , DOI 10.1002/aja.1001710303
dc.descriptionBradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-254
dc.descriptionCarey, A.L., Steinberg, G.R., Macaulay, S.L., Thomas, W.G., Holmes, A.G., Ramm, G., Prelovsek, O., Febbraio, M.A., Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase (2006) Diabetes, 55 (10), pp. 2688-2697. , http://diabetes.diabetesjournals.org/cgi/reprint/55/10/2688, DOI 10.2337/db05-1404
dc.descriptionCarmichael, M.D., Davis, J.M., Murphy, E.A., Carson, J.A., Van Rooijen, N., Mayer, E., Ghaffar, A., Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage (2010) Brain Behav Immun, 24, pp. 564-568
dc.descriptionChen, T.C., Effects of a second bout of maximal eccentric exercise on muscle damage and electromyographic activity (2003) European Journal of Applied Physiology, 89 (2), pp. 115-121
dc.descriptionChen, T.C., Hsieh, S.S., Effects of a 7-day eccentric training period on muscle damage and inflammation (2001) Medicine and Science in Sports and Exercise, 33 (10), pp. 1732-1738
dc.descriptionCosta, A., Dalloul, H., Hegyesi, H., Apor, P., Csende, Z., Racz, L., Vaczi, M., Tihanyi, J., Impact of repeated bouts of eccentric exercise on myogenic gene expression (2007) European Journal of Applied Physiology, 101 (4), pp. 427-436. , DOI 10.1007/s00421-007-0510-z
dc.descriptionDavis, J.M., Murphy, E.A., Carmichael, M.D., Zielinski, M.R., Groschwitz, C.M., Brown, A.S., Gangemi, J.D., Mayer, E.P., Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage (2007) American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 292 (6), pp. R2168-R2173. , http://ajpregu.physiology.org/cgi/reprint/292/6/R2168, DOI 10.1152/ajpregu.00858.2006
dc.descriptionDubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A., Smith, F., Colorimetric method for determination of sugar and related substances (1956) Anal Chem, 28, p. 6
dc.descriptionFerreira, J.C.B., Rolim, N.P.L., Bartholomeu, J.B., Gobatto, C.A., Kokubun, E., Brum, P.C., Maximal lactate steady state in running mice: Effect of exercise training (2007) Clinical and Experimental Pharmacology and Physiology, 34 (8), pp. 760-765. , DOI 10.1111/j.1440-1681.2007.04635.x
dc.descriptionFujimoto, E., Machida, S., Higuchi, M., Tabata, I., Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle (2010) J Physiol Sci, 60, pp. 95-101
dc.descriptionHalson, S.L., Jeukendrup, A.E., Does overtraining exist? An analysis of overreaching and overtraining research (2004) Sports Medicine, 34 (14), pp. 967-981. , DOI 10.2165/00007256-200434140-00003
dc.descriptionHarriss, D.J., Atkinson, G., Update - Ethical standards in sport and exercise science research (2011) Int J Sports Med, 32, pp. 819-821
dc.descriptionHittel, D.S., Axelson, M., Sarna, N., Shearer, J., Huffman, K.M., Kraus, W.E., Myostatin decreases with aerobic exercise and associates with insulin resistance (2010) Med Sci Sports Exerc, 42, pp. 2023-2029
dc.descriptionHohl, R., Ferraresso, R.L., De Oliveira, R.B., Lucco, R., Brenzikofer, R., De Macedo, D.V., Development and characterization of an overtraining animal model (2009) Med Sci Sports Exerc, 41, pp. 1155-1163
dc.descriptionKawanishi, N., Yano, H., Mizokami, T., Takahashi, M., Oyanagi, E., Suzuki, K., Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice (2012) Brain Behav Immun, 26, pp. 931-941
dc.descriptionKeller, C., Steensberg, A., Hansen, A.K., Fischer, C.P., Plomgaard, P., Pedersen, B.K., Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle (2005) Journal of Applied Physiology, 99 (6), pp. 2075-2079. , DOI 10.1152/japplphysiol.00590.2005
dc.descriptionKelly, M., Gauthier, M.S., Saha, A.K., Ruderman, N.B., Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: Association with changes in cAMP, energy state, and endogenous fuel mobilization (2009) Diabetes, 58, pp. 1953-1960
dc.descriptionLi, T.-L., Gleeson, M., The effect of single and repeated bouts of prolonged cycling on leukocyte redistribution, neutrophil degranulation, IL-6, and plasma stress hormone responses (2004) International Journal of Sport Nutrition and Exercise Metabolism, 14 (5), pp. 501-516
dc.descriptionMatsakas, A., Bozzo, C., Cacciani, N., Caliaro, F., Reggiani, C., Mascarello, F., Patruno, M., Effect of swimming on myostatin expression in white and red gastrocnemius muscle and in cardiac muscle of rats (2006) Experimental Physiology, 91 (6), pp. 983-994. , DOI 10.1113/expphysiol.2006.033571
dc.descriptionMeeusen, R., Nederhof, E., Buyse, L., Roelands, B., De Schutter, G., Piacentini, M.F., Diagnosing overtraining in athletes using the two-bout exercise protocol (2010) Br J Sports Med, 44, pp. 642-648
dc.descriptionMeier, P., Renga, M., Hoppeler, H., Baum, O., The impact of antioxidant supplements and endurance exercise on genes of the carbohydrate and lipid metabolism in skeletal muscle of mice (2012) Cell Biochem Funct, , 10.1002/cbf.2859
dc.descriptionMoon, M.K., Cho, B.J., Lee, Y.J., Choi, S.H., Lim, S., Park, K.S., Park, Y.J., Jang, H.C., The effects of chronic exercise on the inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha are different with age (2012) Appl Physiol Nutr Metab, 37, pp. 631-636
dc.descriptionNieman, D.C., Davis, J.M., Henson, D.A., Gross, S.J., Dumke, C.L., Utter, A.C., Vinci, D.M., Triplett, N.T., Muscle cytokine mRNA changes after 2.5 h of cycling: Influence of carbohydrate (2005) Medicine and Science in Sports and Exercise, 37 (8), pp. 1283-1290. , DOI 10.1249/01.mss.0000175054.99588.b1
dc.descriptionNosaka, K., Newton, M., Repeated eccentric exercise bouts do not exacerbate muscle damage and repair (2002) J Strength Cond Res, 16, pp. 117-122
dc.descriptionPedersen, B.K., Muscular interleukin-6 and its role as an energy sensor (2012) Med Sci Sports Exerc, 44, pp. 392-396
dc.descriptionPedersen, B.K., Febbraio, M.A., Muscles, exercise and obesity: Skeletal muscle as a secretory organ (2012) Nat Rev Endocrinol, 8, pp. 457-465
dc.descriptionPedersen, B.K.F.M., Muscle as an endocrine organ: Focus on muscle-derived interleukin-6 (2008) Physiol Rev, 88, p. 27
dc.descriptionPederson, B.A., Cope, C.M., Schroeder, J.M., Smith, M.W., Irimia, J.M., Thurberg, B.L., DePaoli-Roach, A.A., Roach, P.J., Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise (2005) Journal of Biological Chemistry, 280 (17), pp. 17260-17265. , DOI 10.1074/jbc.M410448200
dc.descriptionPereira, B.C., Filho, L.A., Alves, G.F., Pauli, J.R., Ropelle, E.R., Souza, C.T., Cintra, D.E., Silva, A.S., A new overtraining protocol for mice based on downhill running sessions (2012) Clin Exp Pharmacol Physiol, 39, pp. 793-798
dc.descriptionRobson, P.J., Elucidating the unexplained underperformance syndrome in endurance athletes: The interleukin-6 hypothesis (2003) Sports Medicine, 33 (10), pp. 771-781. , DOI 10.2165/00007256-200333100-00004
dc.descriptionRoss, R., Atherosclerosis - An inflammatory disease (1999) New England Journal of Medicine, 340 (2), pp. 115-126. , DOI 10.1056/NEJM199901143400207
dc.descriptionSano, A., Koshinaka, K., Abe, N., Morifuji, M., Koga, J., Kawasaki, E., Kawanaka, K., The effect of high-intensity intermittent swimming on post-exercise glycogen supercompensation in rat skeletal muscle (2012) J Physiol Sci, 62, pp. 1-9
dc.descriptionSmith, L.L., Cytokine hypothesis of overtraining: A physiological adaptation to excessive stress? (2000) Medicine and Science in Sports and Exercise, 32 (2), pp. 317-331
dc.descriptionStarkie, R., Ostrowski, S.R., Jauffred, S., Febbraio, M., Pedersen, B.K., Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans (2003) FASEB Journal: Official Publication of the Federation of American Societies for Exp Biol, 17, pp. 884-886
dc.descriptionSteensberg, A., Febbraio, M.A., Osada, T., Schjerling, P., Van Hall, G., Saltin, B., Pedersen, B.K., Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content (2001) Journal of Physiology, 537 (2), pp. 633-639. , DOI 10.1111/j.1469-7793.2001.00633.x
dc.descriptionSuzuki, A., McCall, S., Choi, S.S., Sicklick, J.K., Huang, J., Qi, Y., Zdanowicz, M., Diehl, A.M., Interleukin-15 increases hepatic regenerative activity (2006) Journal of Hepatology, 45 (3), pp. 410-418. , DOI 10.1016/j.jhep.2006.04.008, PII S0168827806002418
dc.descriptionXiao, W., Chen, P., Dong, J., Effects of overtraining on skeletal muscle growth and gene expression (2012) Int J Sports Med, 33, pp. 846-853
dc.descriptionZhao, B., Wall, R.J., Yang, J., Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance (2005) Biochemical and Biophysical Research Communications, 337 (1), pp. 248-255. , DOI 10.1016/j.bbrc.2005.09.044, PII S0006291X05020371
dc.languageen
dc.publisher
dc.relationInternational Journal of Sports Medicine
dc.rightsaberto
dc.sourceScopus
dc.titleNonfunctional Overreaching Leads To Inflammation And Myostatin Upregulation In Swiss Mice
dc.typeArtículos de revistas


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