| dc.creator | Costa F.C. | |
| dc.creator | Saito T. | |
| dc.creator | Goncalves K.A. | |
| dc.creator | Vidigal P.M. | |
| dc.creator | Meirelles G.V. | |
| dc.creator | Bressan G.C. | |
| dc.creator | Kobarg J. | |
| dc.date | 2014 | |
| dc.date | 2015-06-25T18:02:32Z | |
| dc.date | 2015-11-26T15:04:39Z | |
| dc.date | 2015-06-25T18:02:32Z | |
| dc.date | 2015-11-26T15:04:39Z | |
| dc.date.accessioned | 2018-03-28T22:15:29Z | |
| dc.date.available | 2018-03-28T22:15:29Z | |
| dc.identifier | | |
| dc.identifier | Biochimica Et Biophysica Acta - Molecular Cell Research. Elsevier, v. 1843, n. 12, p. 2944 - 2956, 2014. | |
| dc.identifier | 1674889 | |
| dc.identifier | 10.1016/j.bbamcr.2014.08.016 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84907457136&partnerID=40&md5=aa7eb7aca9cf749a0ba872426a4c2595 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/87851 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/87851 | |
| dc.identifier | 2-s2.0-84907457136 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1256900 | |
| dc.description | Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression levels in tumor cells and the Ki-1/57 gene is found in a region of chromosome 9q that represents a haplotype for familiar colon cancer. However, the target genes regulated by Ki-1/57 and CGI-55 are unknown. Here, we analyzed the alterations of the global transcriptome profile after Ki-1/57 or CGI-55 overexpression in HEK293T cells by DNA microchip technology. We were able to identify 363 or 190 down-regulated and 50 or 27 up-regulated genes for Ki-1/57 and CGI-55, respectively, of which 20 were shared between both proteins. Expression levels of selected genes were confirmed by qRT-PCR both after protein overexpression and siRNA knockdown. The majority of the genes with altered expression were associated to proliferation, apoptosis and cell cycle control processes, prompting us to further explore these contexts experimentally. We observed that overexpression of Ki-1/57 or CGI-55 results in reduced cell proliferation, mainly due to a G1 phase arrest, whereas siRNA knockdown of CGI-55 caused an increase in proliferation. In the case of Ki-1/57 overexpression, we found protection from apoptosis after treatment with the ER-stress inducer thapsigargin. Together, our data give important new insights that may help to explain these proteins putative involvement in tumorigenic events. | |
| dc.description | 1843 | |
| dc.description | 12 | |
| dc.description | 2944 | |
| dc.description | 2956 | |
| dc.description | Kobarg, J., Schnittger, S., Fonatsch, C., Lemke, H., Bowen, M.A., Buck, F., Hansen, H.P., Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen (1997) Exp. Clin. Immunogenet., 14, pp. 273-280 | |
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| dc.description | Lemos, T.A., Passos, D.O., Nery, F.C., Kobarg, J., Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3 (2003) FEBS Lett., 533, pp. 14-20 | |
| dc.description | Kobarg, C.B., Kobarg, J., Crosara-Alberto, D.P., Theizen, T.H., Franchini, K.G., MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57 (2005) FEBS Lett., 579, pp. 2615-2622 | |
| dc.description | Nery, F.C., Rui, E., Kuniyoshi, T.M., Kobarg, J., Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins (2006) Biochem. Biophys. Res. Commun., 341, pp. 847-855 | |
| dc.description | Bressan, G.C., Quaresma, A.J.C., Moraes, E.C., Manfiolli, A.O., Passos, D.O., Gomes, M.D., Kobarg, J., Functional association of human Ki-1/57 with pre-mRNA splicing events (2009) FEBS J., 276, pp. 3770-3783 | |
| dc.description | Gonçalves, K.D.A., Bressan, G.C., Saito, A., Morello, L.G., Zanchin, N.I.T., Kobarg, J., Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery (2011) FEBS Lett., 585, pp. 2556-2560 | |
| dc.description | Nery, F.C., Passos, D.O., Garcia, V.S., Kobarg, J., Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C (2004) J. Biol. Chem., 279, pp. 11444-11455 | |
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| dc.language | en | |
| dc.publisher | Elsevier | |
| dc.relation | Biochimica et Biophysica Acta - Molecular Cell Research | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Ki-1/57 And Cgi-55 Ectopic Expression Impact Cellular Pathways Involved In Proliferation And Stress Response Regulation | |
| dc.type | Artículos de revistas | |
