S-nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation By Redox Posttranslational Modification In Experimental Diabetic Retinopathy

dc.creatorRosales M.A.B.
dc.creatorSilva K.C.
dc.creatorDuarte D.A.
dc.creatorde Oliveira M.G.
dc.creatorde Souza G.F.P.
dc.creatorCatharino R.R.
dc.creatorFerreira M.S.
dc.creatorde Faria J.B.L.
dc.creatorde Faria J.M.L.
dc.date2014
dc.date2015-06-25T18:02:28Z
dc.date2015-11-26T15:04:36Z
dc.date2015-06-25T18:02:28Z
dc.date2015-11-26T15:04:36Z
dc.date.accessioned2018-03-28T22:15:25Z
dc.date.available2018-03-28T22:15:25Z
dc.identifier
dc.identifierInvestigative Ophthalmology And Visual Science. Association For Research In Vision And Ophthalmology Inc., v. 55, n. 5, p. 2921 - 2932, 2014.
dc.identifier1460404
dc.identifier10.1167/iovs.13-13762
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84899724222&partnerID=40&md5=7af5096fa6a57119d6861c4976af2001
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87833
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87833
dc.identifier2-s2.0-84899724222
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256884
dc.descriptionPurpose. Diabetic retinopathy (DR) is associated with nitrosative stress. The purpose of this study was to evaluate the beneficial effects of S-nitrosoglutathione (GSNO) eye drop treatment on an experimental model of DR. Methods. Diabetes (DM) was induced in spontaneously hypertensive rats (SHR). Treated animals received GSNO eye drop (900 nM or 10 μM) twice daily in both eyes for 20 days. The mechanisms of GSNO effects were evaluated in human RPE cell line (ARPE-19). Results. In animals with DM, GSNO decreased inducible nitric oxide synthase (iNOS) expression and prevented tyrosine nitration formation, ameliorating glial dysfunction measured with glial fibrillary acidic protein, resulting in improved retinal function. In contrast, in nondiabetic animals, GSNO induced oxidative/nitrosative stress in tissue resulting in impaired retinal function. Nitrosative stress was present markedly in the RPE layer accompanied by c-wave dysfunction. In vitro study showed that treatment with GSNO under high glucose condition counteracted nitrosative stress due to iNOS downregulation by S-glutathionylation, and not by prevention of decreased GSNO and reduced glutathione levels. This posttranslational modification probably was promoted by the release of oxidized glutathione through GSNO denitrosylation via GSNO-R. In contrast, in the normal glucose condition, GSNO treatment promoted nitrosative stress by NO formation. Conclusions. In this study, a new therapeutic modality (GSNO eye drop) targeting nitrosative stress by redox posttranslational modification of iNOS was efficient against early damage in the retina due to experimental DR. The present work showed the potential clinical implications of balancing the S-nitrosoglutathione/glutathione system in treating DR. © 2014 The Association for Research in Vision and Ophthalmology, Inc.
dc.description55
dc.description5
dc.description2921
dc.description2932
dc.descriptionFong, D.S., Aiello, L., Gardner, T.W., American Diabetes Association. Retinopathy in diabetes (2004) Diabetes Care., 1 (SUPPL.), pp. S84-S87
dc.descriptionZheng, L., Kern, T.S., Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy (2009) Front Biosci., 14, pp. 3974-3987
dc.descriptionGriffith, O.W., Stuehr, D.J., Nitric oxide synthases: Properties and catalytic mechanism (1995) Annu Rev Physiol., 57, pp. 707-736
dc.descriptionKnowles, R.G., Moncada, S., Nitric oxide synthases in mammals (1994) Biochem J., 298, pp. 249-258
dc.descriptionMoncada, S., Bolanos, J.P., Nitric oxide, cell bioenergetics and neurodegeneration (2006) Neurochem., 97, pp. 1676-1689
dc.descriptionSchmidt, H.H., Walter, U., NO at work (1994) Cell., 78, pp. 919-925
dc.descriptionWei, W., Li, B., Hanes, M.A., Kakar, S., Chen, X., Liu, L., S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis (2010) SciTransl Med., 2, pp. 19ra13
dc.descriptionHess, D.T., Matsumoto, A., Kim, S.O., Marshall, H.E., Stamler, J.S., Protein S-nitrosylation purview and parameters (2005) Nat Rev Mol Cell Biol., 6, pp. 150-166
dc.descriptionFoster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol Med., 9, pp. 160-168
dc.descriptionDu, Y., Sarthy, V.P., Kern, T.S., Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats (2004) Am J Physiol Regul Integr Comp Physiol., 287, pp. 735-741
dc.descriptionRosales, M.A., Silva, K.C., de Faria Lopes, J.B., de Faria Lopes, J.M., Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats (2010) Invest Ophthalmol Vis Sci., 51, pp. 4327-4336
dc.descriptionSilva, K.C., Rosales, M.A., de Faria, J.B., de Faria, J.M., Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats (2010) Curr Eye Res., 35, pp. 519-528
dc.descriptionAbu El-Asrar, A.M., Desmet, S., Meersschaert, A., Dralands, L., Missotten, L., Geboes, K., Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus (2001) Am J Ophthalmol., 132, pp. 551-556
dc.descriptionHernández, C., Lecube, A., Segura, R.M., Sararols, L., Simó, R., Nitric oxide and vascular endothelial growth factor concentrations are increased but not related in vitreous fluid of patients with proliferative diabetic retinopathy (2002) Diabet Med., 19, pp. 655-660
dc.descriptionLiu, Z., Rudd, M.A., Freedman, J.E., Loscalzo, J., S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide (1998) J Pharmacol Exp Ther., 284, pp. 526-534
dc.descriptionStamler, J.S., Lamas, S., Fang, F.C., Nitrosylation, the prototypic redox-based signaling mechanism (2001) Cell., 106, pp. 675-683
dc.descriptionHogg, N., The biochemistry and physiology of S-nitrosothiols (2002) Annu Rev Pharmacol Toxicol., 42, pp. 585-600
dc.descriptionSingh, S.P., Wishnok, J.S., Keshive, M., Deen, W.M., Tannenbaum, S.R., The chemistry of the S-nitrosoglutathione/glutathione system (1996) Proc Natl Acad Sci USA., 93, pp. 14428-14433
dc.descriptionZeng, H., Spencer, N.Y., Hogg, N., Metabolism of S-nitrosoglutathione by endothelial cells (2001) Am J Physiol Heart Circ Physiol., 281, pp. 432-439
dc.descriptionHedberg, J.J., Griffiths, W.J., Nilsson, S.J., Hoog, J.O., Reduction of Snitrosoglutathione by human alcoholdehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry (2003) Eur J Biochem., 270, pp. 1249-1256
dc.descriptionLiu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., Stamler, J.S., A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans (2001) Nature., 410, pp. 490-494
dc.descriptionKhan, M., Sekhon, B., Giri, S., S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke (2005) J Cereb Blood Flow Metab., 25, pp. 177-192
dc.descriptionHaq, E., Rohrer, B., Nath, N., Crosson, C.E., Singh, I., S-nitrosoglutathione prevents interphotoreceptor retinoid-binding protein (IRBP(161-180)-induced experimental autoimmune uveitis (2007) J Ocul Pharmacol Ther., 23, pp. 221-231
dc.descriptionHoltkamp, G.M., Kijlstra, A., Peek, R., de Vos, A.F., Retinal pigment epithelium-immune system interactions: Cytokine production and cytokine-induced changes (2001) Prog Retin Eye Res., 20, pp. 29-48
dc.descriptionGoureau, O., Lepoivre, M., Becquet, F., Courtois, Y., Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor b in bovine retinal pigmented epithelial cells: Inverse correlation with cellular proliferation (1993) Proc Natl Acad Sci U S A., 90, pp. 4276-4280
dc.descriptionLiversidge, J., Grabowski, P., Ralston, S., Benjamin, N., Forrester, J.V., Rats retinal pigment epithelial cells express an inducible form of nitric oxide synthase and produce nitric oxide in response to inflammatory cytokines and activated T cells (1994) Immunology., 83, pp. 404-409
dc.descriptionPinto, C.C., Silva, K.C., Biswas, S.K., Martins, N., de Faria, J.B., de Faria, J.M., Arterial hypertension exacerbates oxidative stress in early diabetic retinopathy (2007) Free Radic Res., 41, pp. 1151-1158
dc.descriptionSilva, K.C., Pinto, C.C., Biswas, S.K., de Faria, J.B., de Faria, J.M., Hypertension increases retinal inflammation in experimental diabetes: A possible mechanism for aggravation of diabetic retinopathy by hypertension (2007) Curr Eye Res., 32, pp. 533-541
dc.descriptionMosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J Immunol Meth., 65, pp. 55-63
dc.descriptionBui, B.V., Armitage, J.A., Tolcos, M., Cooper, M.E., Vingrys, A.J., ACE inhibition salvages the visual loss caused by diabetes (2003) Diabetologia., 46, pp. 401-408
dc.descriptionSilva, K.C., Rosales, M.A., Hamassaki, D.E., Green tea is neuroprotective in diabetic retinopathy (2013) Invest Ophthalmol Vis Sci., 54, pp. 1325-1336
dc.descriptionGarcia-Ramirez, M., Villarroel, M., Corraliza, L., Hernández, C., Simó, R., Measuring permeability in human retinal epithelial cells (ARPE-19): Implications for the study of diabetic retinopathy (2011) Methods Mol Biol., 763, pp. 179-194
dc.descriptionFaria, A.M., Papadimitriou, A., Silva, K.C., de Faria Lopes, J.M., de Faria Lopes, J.B., Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by reestablishing tetrahydrobiopterin levels (2012) Diabetes., 61, pp. 1838-1847
dc.descriptionBeutler, E., Duron, O., Kelly, B.M., Improved method for the determination of blood glutathione (1963) J Lab Clin Med., 16, pp. 882-888
dc.descriptionYap, L.P., Sancheti, H., Ybanez, M.D., Garcia, J., Cadenas, E., Han, D., Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection (2010) Methods Enzymol., 473, pp. 137-147
dc.descriptionMoore, W.M., Webber, R.K., Jerome, G.M., Tjoeng, F.S., Misko, T.P., Currie, M.G., L-N6-(1-iminoethyl) lysine: A selective inhibitor of inducible nitric oxide synthase (1994) J Med Chem., 37, pp. 3886-3888
dc.descriptionSchafer, F.Q., Buettner, G.R., Redox environment of the cell as viewed through the redox state of the glutathione disulfide/ glutathione couple (2001) Free Radic Biol Med., 30, pp. 1191-1212
dc.descriptionBallatori, N., Krance, S.M., Notenboom, S., Shi, S., Tieu, K., Hammond, C.L., Glutathione dysregulation and the etiology and progression of human diseases (2009) Biol Chem., 390, pp. 191-214
dc.descriptionMoellering, D., McAndrew, J., Patel, R.P., Nitric oxidedependent induction of glutathione synthesis through increased expression of gamma-glutamylcysteine synthetase (1998) Arch Biochem Biophys., 358, pp. 74-82
dc.descriptionNikitovic, D., Holmgren, A., S-Nitrosoglutathione is cleaved by the thioredoxin system with liberation of glutathione and redox regulating nitric oxide (1996) J Biol Chem., 271, pp. 19180-19185
dc.descriptionChen, C.A., Wang, T.Y., Varadharaj, S., S-glutathionylation uncouples eNOS and regulates its cellular and vascular function (2010) Nature., 468, pp. 1115-1118
dc.descriptionRosenfeld, R.J., Bonaventura, J., Szymczyna, B.R., Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: Implications for activity, allostery, and regulation (2010) J Biol Chem., 285, pp. 31581-31589
dc.descriptionPacher, P., Beckman, J.S., Liaudet, L., Nitric oxide and peroxynitrite in health and disease (2007) Physiol Rev., 87, pp. 315-424
dc.descriptionPacher, P., Obrosova, I.G., Mabley, J.G., Szabo, C., Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies (2005) Curr Med Chem., 12, pp. 267-275
dc.descriptionKowluru, R.A., Engerman, R.L., Kern, T.S., Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine (2000) Curr Eye Res., 21, pp. 814-819
dc.descriptiondo Carmo, A., Lopes, C., Santos, M., Proenca, R., Cunha-Vaz, J., Carvalho, A.P., Nitric oxide synthase activity and L-arginine metabolism in the retinas from streptozotocin induced diabetic rats (1998) Gen Pharmacol., 30, pp. 319-324
dc.descriptionSennlaub, F., Courtois, Y., Goureau, O., Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy (2001) J Clin Invest., 107, pp. 717-725
dc.descriptionSennlaub, F., Courtois, Y., Goureau, O., Inducible nitric oxide synthase mediates the retinal apoptosis in ischemic proliferative retinopathy (2002) J Neurosci., 22, pp. 3987-3993
dc.descriptionZheng, L., Du, Y., Miller, C., Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes (2007) Diabetologia., 50, pp. 1987-1996
dc.descriptionSchuhmacher, S., Oelze, M., Bollmann, F., Vascular dysfunction in experimental diabetes is improved by pentaerithrityltetranitrate but not isosorbide-5-mononitrate therapy (2011) Diabetes., 60, pp. 2608-2616
dc.descriptionFoster, M.W., Liu, L., Zeng, M., Hess, D.T., Stamler, J.S., A genetic analysis of nitrosative stress (2009) Biochemistry., 48, pp. 792-799
dc.descriptionBateman, R.L., Rauh, D., Tavshanjian, B., Shokat, K.M., Human carbonyl reductase 1 is an S-nitrosoglutathione reductase (2008) J Biol Chem., 283, pp. 35756-35762
dc.descriptionLiu, L., Yan, Y., Zeng, M., Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock (2004) Cell., 116, pp. 617-628
dc.languageen
dc.publisherAssociation for Research in Vision and Ophthalmology Inc.
dc.relationInvestigative Ophthalmology and Visual Science
dc.rightsfechado
dc.sourceScopus
dc.titleS-nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation By Redox Posttranslational Modification In Experimental Diabetic Retinopathy
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución