Increased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate

dc.creatorNunes V.S.
dc.creatorPanzoldo N.B.
dc.creatorLeanca C.C.
dc.creatorParra E.S.
dc.creatorZago V.S.
dc.creatorda Silva E.J.
dc.creatorCazita P.M.
dc.creatorNakandakare E.R.
dc.creatorde Faria E.C.
dc.creatorQuintao E.C.R.
dc.date2014
dc.date2015-06-25T18:02:23Z
dc.date2015-11-26T15:04:28Z
dc.date2015-06-25T18:02:23Z
dc.date2015-11-26T15:04:28Z
dc.date.accessioned2018-03-28T22:15:16Z
dc.date.available2018-03-28T22:15:16Z
dc.identifier
dc.identifierClinica Chimica Acta. Elsevier, v. 433, n. , p. 169 - 173, 2014.
dc.identifier98981
dc.identifier10.1016/j.cca.2014.03.017
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84897387988&partnerID=40&md5=f25d1024234cda095874b75fcb801f93
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87809
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87809
dc.identifier2-s2.0-84897387988
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256850
dc.descriptionBackground: HDL is considered the most important mechanism for the excretion of intracellular cholesterol. The liver is the only organ capable to metabolize cholesterol into bile acid. The enzymatic conversion of cholesterol to bile acid is dependent on the cytochrome P450 microsomal system which is also responsible for the generation of oxysterols. The latter's plasma concentrations may reflect the metabolic processes of specific tissues where they are generated. The objective of this study was to investigate in healthy individuals who differ according to their HDL levels the concentration of oxysterols and relate it to the HDL-dependent cell cholesterol efflux rate. Methods: 24-Hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol were determined in plasma by GLC/mass spectrometry in 107 healthy subjects with low HDL (HDL-C. <. 1.03. mmol/l) and high HDL cholesterol (HDL-C. >. 1.55. mmol/l). HDL-dependent in vitro cell cholesterol efflux rate was measured in 29 cases. Results: No differences were found in plasma oxysterol concentrations between the Low HDL and High HDL groups. There was a significant negative correlation between HDL-C and 27-hydroxycholesterol. Plasma oxysterol concentrations were significantly lower in female than in male subjects. The Low HDL male group had higher 27-hydroxycholesterol than the High HDL male group. Cell cholesterol efflux rate was lower in Low HDL than in High HDL and related inversely with 27-hydroxycholesterol. Conclusion: As compared to High HDL, Low HDL men have increased 27-hydroxycholesterol plasma level that may circumvent their reduced cell cholesterol efflux rate. © 2014 Elsevier B.V.
dc.description433
dc.description
dc.description169
dc.description173
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dc.languageen
dc.publisherElsevier
dc.relationClinica Chimica Acta
dc.rightsfechado
dc.sourceScopus
dc.titleIncreased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate
dc.typeArtículos de revistas


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