Anti-hemorrhagic Effect Of Hydro-alcoholic Extract Of The Leaves Of Mikania Glomerata In Lesions Induced By Bothrops Jararaca Venom In Rats

dc.creatorMourao V.B.
dc.creatorGiraldi G.M.
dc.creatorNeves L.M.G.
dc.creatorde Gaspari de Gaspi F.O.
dc.creatorRodrigues R.A.F.
dc.creatorAlves A.A.
dc.creatorEsquisatto M.A.M.
dc.creatorMazzi M.V.
dc.creatorMendonca F.A.S.
dc.creatordos Santos G.M.T.
dc.date2014
dc.date2015-06-25T18:01:54Z
dc.date2015-11-26T15:03:52Z
dc.date2015-06-25T18:01:54Z
dc.date2015-11-26T15:03:52Z
dc.date.accessioned2018-03-28T22:14:42Z
dc.date.available2018-03-28T22:14:42Z
dc.identifier
dc.identifierActa Cirurgica Brasileira. , v. 29, n. 1, p. 30 - 37, 2014.
dc.identifier1028650
dc.identifier10.1590/S0102-86502014000100005
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84892605591&partnerID=40&md5=0424fd8da785b7fc5eb33cb0a6e9c192
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87692
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87692
dc.identifier2-s2.0-84892605591
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256713
dc.descriptionPurpose: To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats. Methods: Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4. Results: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata. Conclusion: The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.
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dc.languageen
dc.publisher
dc.relationActa Cirurgica Brasileira
dc.rightsaberto
dc.sourceScopus
dc.titleAnti-hemorrhagic Effect Of Hydro-alcoholic Extract Of The Leaves Of Mikania Glomerata In Lesions Induced By Bothrops Jararaca Venom In Rats
dc.typeArtículos de revistas


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