Reduced Insulin Clearance And Lower Insulin-degrading Enzyme Expression In The Liver Might Contribute To The Thrifty Phenotype Of Protein-restricted Mice

dc.creatorRezende L.F.
dc.creatorCamargo R.L.
dc.creatorBranco R.C.S.
dc.creatorCappelli A.P.G.
dc.creatorBoschero A.C.
dc.creatorCarneiro E.M.
dc.date2014
dc.date2015-06-25T18:01:47Z
dc.date2015-11-26T15:03:45Z
dc.date2015-06-25T18:01:47Z
dc.date2015-11-26T15:03:45Z
dc.date.accessioned2018-03-28T22:14:35Z
dc.date.available2018-03-28T22:14:35Z
dc.identifier
dc.identifierBritish Journal Of Nutrition. Cambridge University Press, v. 112, n. 6, p. 900 - 907, 2014.
dc.identifier71145
dc.identifier10.1017/S0007114514001238
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84912014155&partnerID=40&md5=8bc9fc811a47b0510b45c14cb3fc8502
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87666
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87666
dc.identifier2-s2.0-84912014155
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256682
dc.descriptionNutrient restriction during the early stages of life usually leads to alterations in glucose homeostasis, mainly insulin secretion and sensitivity, increasing the risk of metabolic disorders in adulthood. Despite growing evidence regarding the importance of insulin clearance during glucose homeostasis in health and disease, no information exists about this process in malnourished animals. Thus, in the present study, we aimed to determine the effect of a nutrient-restricted diet on insulin clearance using a model in which 30-d-old C57BL/6 mice were exposed to a protein-restricted diet for 14 weeks. After this period, we evaluated many metabolic variables and extracted pancreatic islet, liver, gastrocnemius muscle (GCK) and white adipose tissue samples from the control (normal-protein diet) and restricted (low-protein diet, LP) mice. Insulin concentrations were determined using RIA and protein expression and phosphorylation by Western blot analysis. The LP mice exhibited lower body weight, glycaemia, and insulinaemia, increased glucose tolerance and altered insulin dynamics after the glucose challenge. The improved glucose tolerance could partially be explained by an increase in insulin sensitivity through the phosphorylation of the insulin receptor/protein kinase B and AMP-activated protein kinase/acetyl-CoA carboxylase in the liver, whereas the changes in insulin dynamics could be attributed to reduced insulin secretion coupled with reduced insulin clearance and lower insulin-degrading enzyme (IDE) expression in the liver and GCK. In summary, protein-restricted mice not only produce and secrete less insulin, but also remove and degrade less insulin. This phenomenon has the double benefit of sparing insulin while prolonging and potentiating its effects, probably due to the lower expression of IDE in the liver, possibly with long-term consequences.
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dc.description900
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dc.languageen
dc.publisherCambridge University Press
dc.relationBritish Journal of Nutrition
dc.rightsfechado
dc.sourceScopus
dc.titleReduced Insulin Clearance And Lower Insulin-degrading Enzyme Expression In The Liver Might Contribute To The Thrifty Phenotype Of Protein-restricted Mice
dc.typeArtículos de revistas


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