Chemoprotection Of Mnng-initiated Gastric Cancer In Rats Using Iranian Propolis

dc.creatorAlizadeh A.M.
dc.creatorAfrouzan H.
dc.creatorDinparast-Djadid N.
dc.creatorSawaya A.C.H.F.
dc.creatorAzizian S.
dc.creatorHemmati H.R.
dc.creatorMohagheghi M.A.
dc.creatorErfani S.
dc.date2015
dc.date2015-06-25T12:52:18Z
dc.date2015-11-26T15:03:19Z
dc.date2015-06-25T12:52:18Z
dc.date2015-11-26T15:03:19Z
dc.date.accessioned2018-03-28T22:14:11Z
dc.date.available2018-03-28T22:14:11Z
dc.identifier
dc.identifierArchives Of Iranian Medicine. Academy Of Medical Sciences Of I.r. Iran, v. 18, n. 1, p. 18 - 23, 2015.
dc.identifier10292977
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84920999052&partnerID=40&md5=a61474b81fe3ca73f0202920469b495c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85376
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85376
dc.identifier2-s2.0-84920999052
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256587
dc.descriptionBackground: Iranian propolis is a natural product of honeybees that has significant and varied anti-cancer benefits. The present study was designed to investigate the protective effects of Iranian propolis on gastric tissue carcinogenesis in an animal model.Method: Propolis samples were collected from Hamadan and Taleghan districts of Iran, followed by ultra performance liquid chromatography mass spectrometry analysis. Fifty-five rats were divided into three groups; control, Taleghan propolis and Hamadan propolis. All the animals received N-methyl-N-nitro-N-nitrosoguanidine (MNNG, 100 |jg/ml_) in drinking water ad libitum for 34 weeks. In the treated groups, nutrition with propolis was started two weeks before MNNG administration. At the end of the study, the entire gastrointestinal tract was scrutinized for tumors, and the rest of the body was assessed for metastatic deposits.Results: Results indicated that the incidence and number of tumors were significantly decreased by propolis in comparison with the control group (P < 0.05). The nuclear/cytoplasmic ratio, epithelial stratification, nuclear dispolarity, structural abnormality, and Beta-catenin and Bcl-2 proteins expression were significantly reduced in the propolis group compared to the control group (P < 0.05). In addition, Bax protein expression was significantly increased in the propolis group in comparison with the control group (P < 0.05).Conclusion: The present study demonstrated the potential chemoprotective effects of the Iranian propolis against gastric cancer in a typical animal model. The results provide evidence for the hypothesis that Iranian propolis may exert a chemoprotective effect on MNNG- initiated gastric cancer through inhibition of cell proliferation and apoptosis induction.
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dc.languageen
dc.publisherAcademy of Medical Sciences of I.R. Iran
dc.relationArchives of Iranian Medicine
dc.rightsfechado
dc.sourceScopus
dc.titleChemoprotection Of Mnng-initiated Gastric Cancer In Rats Using Iranian Propolis
dc.typeArtículos de revistas


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