Diagnosis, Treatment, And Follow-up Of Medullary Thyroid Carcinoma: Recommendations By The Thyroid Department Of The Brazilian Society Of Endocrinology And Metabolism [diagnóstico, Tratamento E Seguimento Do Carcinoma Medular De Tireoide: Recomendações Do Departamento De Tireoide Da Sociedade Brasileira De Endocrinologia E Metabologia]

dc.creatorMaia A.L.
dc.creatorSiqueira D.R.
dc.creatorKulcsar M.A.V.
dc.creatorTincani A.J.
dc.creatorMazeto G.M.F.S.
dc.creatorMaciel L.M.Z.
dc.date2014
dc.date2015-06-25T17:59:55Z
dc.date2015-11-26T15:01:59Z
dc.date2015-06-25T17:59:55Z
dc.date2015-11-26T15:01:59Z
dc.date.accessioned2018-03-28T22:12:57Z
dc.date.available2018-03-28T22:12:57Z
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. , v. 58, n. 7, p. 667 - 700, 2014.
dc.identifier10.1590/0004-2730000003427
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84908387333&partnerID=40&md5=d224bf17cd778288cef6d6fa7e09341f
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87372
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87372
dc.identifier2-s2.0-84908387333
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256382
dc.descriptionIntroduction: Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and represents 3-4% of the malignant neoplasms that affect this gland. Approximately 25% of these cases are hereditary due to activating mutations in the REarranged during Transfection (RET) proto-oncogene. The course of MTC is indolent, and survival rates depend on the tumor stage at diagnosis. The present article describes clinical evidence-based guidelines for the diagnosis, treatment, and follow-up of MTC. Objective: The aim of the consensus described herein, which was elaborated by Brazilian experts and sponsored by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism, was to discuss the diagnosis, treatment, and follow-up of individuals with MTC in accordance with the latest evidence reported in the literature. Materials and methods: After clinical questions were elaborated, the available literature was initially surveyed for evidence in the MedLine-PubMed database, followed by the Embase and Scientific Electronic Library Online/Latin American and Caribbean Health Science Literature (SciELO/Lilacs) databases. The strength of evidence was assessed according to the Oxford classification of evidence levels, which is based on study design, and the best evidence available for each question was selected. Results: Eleven questions corresponded to MTC diagnosis, 8 corresponded to its surgical treatment, and 13 corresponded to follow-up, for a total of 32 recommendations. The present article discusses the clinical and molecular diagnosis, initial surgical treatment, and postoperative management of MTC, as well as the therapeutic options for metastatic disease. Conclusions: MTC should be suspected in individuals who present with thyroid nodules and family histories of MTC, associations with pheochromocytoma and hyperparathyroidism, and/or typical phenotypic characteristics such as ganglioneuromatosis and Marfanoid habitus. Fine-needle nodule aspiration, serum calcitonin measurements, and anatomical-pathological examinations are useful for diagnostic confirmation. Surgery represents the only curative therapeutic strategy. The therapeutic options for metastatic disease remain limited and are restricted to disease control. Judicious postoperative assessments that focus on the identification of residual or recurrent disease are of paramount importance when defining the follow-up and later therapeutic management strategies.
dc.description58
dc.description7
dc.description667
dc.description700
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dc.relationArquivos Brasileiros de Endocrinologia e Metabologia
dc.rightsfechado
dc.sourceScopus
dc.titleDiagnosis, Treatment, And Follow-up Of Medullary Thyroid Carcinoma: Recommendations By The Thyroid Department Of The Brazilian Society Of Endocrinology And Metabolism [diagnóstico, Tratamento E Seguimento Do Carcinoma Medular De Tireoide: Recomendações Do Departamento De Tireoide Da Sociedade Brasileira De Endocrinologia E Metabologia]
dc.typeArtículos de revistas


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