Update On Pathways Regulating The Activation Of Uterine Natural Killer Cells, Their Interactions With Decidual Spiral Arteries And Homing Of Their Precursors To The Uterus

dc.creatorCroy B.A.
dc.creatorEsadeg S.
dc.creatorChantakru S.
dc.creatorVan Den Heuvel M.
dc.creatorPaffaro Jr. V.A.
dc.creatorHe H.
dc.creatorBlack G.P.
dc.creatorAshkar A.A.
dc.creatorKiso Y.
dc.creatorZhang J.
dc.date2003
dc.date2015-06-30T17:28:26Z
dc.date2015-11-26T15:00:02Z
dc.date2015-06-30T17:28:26Z
dc.date2015-11-26T15:00:02Z
dc.date.accessioned2018-03-28T22:11:26Z
dc.date.available2018-03-28T22:11:26Z
dc.identifier
dc.identifierJournal Of Reproductive Immunology. , v. 59, n. 2, p. 175 - 191, 2003.
dc.identifier1650378
dc.identifier10.1016/S0165-0378(03)00046-9
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-12444251707&partnerID=40&md5=2d218b99c78e8fda0a29d9b31f56bbc5
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102156
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102156
dc.identifier2-s2.0-12444251707
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256135
dc.descriptionVirgin adult C57Bl/6J mouse uterus contains a population of small, non-granulated Natural Killer (NK) cells with balanced expression of NK cell activating and inhibiting LY49 receptors. Coincident with blastocyst implantation and decidualization, uterine (u)NK cells become activated. The surface glycoslyation of uNK changes, the cells proliferate and they induce production of interferon (IFN)γ, perforin, serine esterases and other molecules, including angiogenic factors. Mouse strains genetically ablated in uNK cells fail to undergo modification of spiral artery segments that branch from the uterine artery and feed into the placenta and these mice do not sustain a robust decidualization response. IFN-γ is thought, from bone marrow transplantation and therapeutic studies, to be the key uNK-cell derived mediator regulating gene expression in vascular and decidual tissues. Here, we review recent studies showing that IL-15 is the critical cytokine controlling uNK cell differentiation and that uNK cells are activated by either IL-12 or IL-18 and by other factors when both IL-12 and IL-18 are genetically absent from implantation sites. We address possible roles of the IFN-γ regulated gene α2-macroglobulin (α2-M) in regulation of the position of fetal trophoblast within the walls of the spiral arteries, and we discuss approaches that have been successful in evaluating mechanisms involved in homing of mouse uNK cell precursors to the uterus. These approaches maybe applicable to studies in women. Our studies show that complex immuno-physiological events contribute to spiral artery modification by mid-gestation in mice. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
dc.description59
dc.description2
dc.description175
dc.description191
dc.descriptionAnderson, S.K., Ortaldo, J.R., McVicar, D.W., The ever-expanding Ly49 gene family: Repertoire and signaling (2001) Immunol. Rev., 181, pp. 79-89
dc.descriptionAshkar, A.A., (2000) Functions of uterine natural killer cell-derived interferon gamma in the pregnant mouse uterus, , Ph.D. thesis, University of Guelph
dc.descriptionAshkar, A.A., Croy, B.A., Interferon-gamma contributes to the normalcy of murine pregnancy (1999) Biol. Reprod., 61, pp. 493-502
dc.descriptionAshkar, A.A., Di Santo, J.P., Croy, B.A., Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy (2000) J. Exp. Med., 192, pp. 259-270
dc.descriptionBlery, M., Olcese, L., Vivier, E., Early signaling via inhibitory and activating NK receptors (2000) Hum. Immunol., 61, pp. 51-64
dc.descriptionBoehm, U., Guethlein, L., Klamp, T., Ozbek, K., Schaub, A., Futterer, A., Pfeffer, K., Howard, J.C., Two families of GTPases dominate the complex cellular response to IFN-gamma (1998) J. Immunol., 161, pp. 6715-6723
dc.descriptionBriard, D., Brouty-Boye, D., Azzarone, B., Jasmin, C., Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15 (2002) J. Immunol., 168, pp. 4326-4332
dc.descriptionCampbell, K.S., Colonna, M., Human natural killer cell receptors and signal transduction (2001) Int. Rev. Immunol., 20, pp. 333-370
dc.descriptionChantakru, S., (1998) Assessment of uterus and spleen as sources of uterine natural killer cell precursors in murine pregnancy, , M.Sc. thesis, University of Guelph
dc.descriptionChantakru, W., Miller, C., Roach, L.E., Kuziel, W.A., Maeda, N., Wang, W.C., Evans, S.S., Croy, B.A., Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy (2002) J. Immunol., 168, pp. 22-28
dc.descriptionChantakru, S., Wang, W.-C., Croy, B.A., Evans, S.S., (2003) Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones, , Submitted for publication
dc.descriptionChaouat, G., Zourbas, S., Ostojic, S., Lappree-Delage, G., Dubanchet, S., Ledee, N., Martal, J., A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy (2002) J. Reprod. Immunol., 53, pp. 241-256
dc.descriptionChen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.H., Gurney, A., Grewal, I.S., De Sauvage, F.J., Development of Th1-type immune responses requires the type I cytokine receptor TCCR (2000) Nature, 407, pp. 916-920
dc.descriptionColucci, F., Di Santo, J.P., Liebson, P.J., Natural killer cell activation in mice and men: Different triggers for similar weapons (2002) Nat. Immunol., 3, pp. 807-813
dc.descriptionCroy, B.A., Ashkar, A.A., Foster, R.A., DiSanto, J.P., Magram, J., Carson, D., Gendler, S.J., Guimond, M.J., Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy (1997) J. Reprod. Immunol., 35, pp. 111-133
dc.descriptionCroy, B.A., Black, G.P., Ashkar, A.A., Analysis of the roles of interleukin 15 during the differentiation of uterine natural killer cells (2002) Proceedings of the 19th International Natural Killer Cell Workshop, , October 2002, San Juan, PR
dc.descriptionCroy, B.A., Chantakru, S., Esadeg, S., Ashkar, A.A., Wei, Q., Decidual natural killer cells: Key regulators of placental development (a review) (2002) J. Reprod. Immunol., 57, pp. 151-168
dc.descriptionDelgado, S.R., McBey, B.-A., Yamashiro, S., Fujita, J., Kiso, Y., Croy, B.A., Accounting for the peripartum loss of granulated metrial gland cells, a natural killer cell population, from the pregnant mouse uterus (1996) J. Leukocyte Biol., 59, pp. 262-269
dc.descriptionDevergne, O., Colomb-L'Hermine, A., Capel, F., Moussa, M., Capron, F., Expression of Epstein-Barr virus-induce gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: Involvement of syncytiotrophoblast and extravillous trophoblasts (2001) Am. J. Pathol., 159, pp. 1763-1776
dc.descriptionDunn, C.L., Critchley, H.O., Kelly, R.W., IL-15 regulation in human endometrial stromal cells (2002) J. Clin. Endocrinol. Metab., 87, pp. 1898-1901
dc.descriptionEsadeg, S., Paffaro, V.A., Wei, Q., He, H., Van Leuven, F., Croy, B.A., Alpha2-macroglobulins participate in pregnancy-associated spiral artery modifications (2002) Hypertension Pregnancy, 21 (SUPPL. 1), p. 18. , Abstract O035
dc.descriptionGambel, P., Croy, B.A., Moore, W.D., Hunziker, R.D., Wegmann, T.G., Rossant, J., Characterization of immune effector cells present in early murine decidua (1985) Cell. Immunol., 93, pp. 303-314
dc.descriptionGerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G., Trinchieri, G., Reciprocal activating interaction between natural killer cells and dendritic cells (2002) J. Exp. Med., 195, pp. 327-333
dc.descriptionGreenwood, J.D., Minhas, K., Di Santo, J.P., Makita, M., Kiso, Y., Croy, B.A., Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells (2000) Placenta, 21, pp. 693-702
dc.descriptionGuimond, J., Wang, B., Croy, B.A., Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice (1998) J. Exp. Med., 187, pp. 217-223
dc.descriptionKabat, J., Borrego, F., Brooks, A., Coligan, J.E., Role that each NKG2A immuno-receptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal (2002) J. Immunol., 169, pp. 1948-1958
dc.descriptionKather, A., Chantakru, S., He, H., Minhas, K., Foster, R., Markert, U.R., Pfeffer, K., Croy, B.A., Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus (2003) Immunology, 180, pp. 1-8
dc.descriptionKing, A., Jokhi, P.P., Burrows, T.D., Gardner, L., Sharkey, A.M., Loke, Y.W., Functions of human decidual NK cells (1996) Am. J. Reprod. Immunol., 35, pp. 258-260
dc.descriptionKiso, Y., McBey, B.-A., Mason, L., Croy, B.A., Histological assessment of the mouse uterus from birth to puberty for the appearance of LGL-1+ natural killer cells (1992) Biol. Reprod., 47, pp. 227-232
dc.descriptionKitaya, K., Yasuda, J., Yagi, I., Tada, Y., Fushiki, S., Honjo, H., IL-15 expression at human endometrium and decidua (2000) Biol. Reprod., 63, pp. 683-687
dc.descriptionKruse, A., Martens, N., Fernekorn, U., Hallmann, R., Butcher, E.C., Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy (2002) Biol. Reprod., 66, pp. 333-345
dc.descriptionLaMarre, J., Wollenberg, G.K., Gonias, S.L., Hayes, M.A., Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins (1991) Lab. Invest., 65, pp. 3-14
dc.descriptionLi, P., McDermott, G., Strong, R.K., Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D (2002) Immunity, 16, pp. 77-86
dc.descriptionLopez-Botet, M., Bellon, T., Llano, M., Navarro, F., Garcia, P., De Miguel, M., Paired inhibitory and triggering NK cell receptors for HLA class I molecules (2000) Hum. Immunol., 61, pp. 7-17
dc.descriptionMiller, S.C., Production and renewal of murine natural killer cells in the spleen and bone marrow (1982) J. Immunol., 129, pp. 2282-2286
dc.descriptionMoffett-King, A., Natural killer cells and pregnancy (2002) Nat. Rev. Immunol., 2, pp. 656-663
dc.descriptionNakanishi, K., Yoshimoto, T., Tsutsui, H., Okamura, H., Interleukin-18 regulates both Th1 and Th2 responses (2001) Annu. Rev. Immunol., 19, pp. 423-474
dc.descriptionNomura, M., Zou, Z., Joh, T., Takihara, Y., Matsuda, Y., Shimada, K., Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain (1996) J. Biochem., 120, pp. 987-995
dc.descriptionOkada, H., Nakajima, T., Sanezumi, M., Ikuta, A., Yasuda, K., Kanzaki, H., Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro (2000) J. Clin. Endocrinol. Metab., 85, pp. 4765-4770
dc.descriptionOrtaldo, J.R., Winkler-Pickett, R., Willette-Brown, J., Wange, R.L., Anderson, S.K., Palumbo, G.J., Mason, L.H., McVicar, D.W., Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors (1999) J. Immunol., 163, pp. 5259-5277
dc.descriptionOrtaldo, J.R., Bere, E.W., Hodge, D., Young, H.A., Activating Ly-49 NK receptors: Central role in cytokine and chemokine production (2001) J. Immunol., 166, pp. 4994-4999
dc.descriptionPaffaro, V.A., Bizinotto, M.C., Joazeiro, P.P., Yamada, A.T., Identification and quantification of mouse uterine NK cells by DBA stain (2003) Placenta, , in press
dc.descriptionPaffaro, V.A., He, H., Yamada, A.T., Croy, B.A., Ly49 gene expression by natural killer cells localized to mouse uterus (2003) Placenta, , submitted for publication
dc.descriptionParr, E.L., Parr, M.B., Zheng, L.M., Young, J.D., Mouse granulated metrial gland cells originate by local activation of uterine natural killer lymphocytes (1991) Biol. Reprod., 44, pp. 834-841
dc.descriptionPeel, S., Granulated metrial gland cells (1989) Adv. Anat. Embryol. Cell Biol., 115, pp. 1-112
dc.descriptionPflanz, S., Timans, J.C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Kastelein, R.A., IL-27, a heterodimeric cytokine composed of EB13 and p28 protein, induces proliferation of naive CD4(+) T cells (2002) Immunity, 16, pp. 190-779
dc.descriptionPlatt, J.S., Hunt, J.S., Interferon-gamma gene expression in cycling and pregnant mouse uterus: Temporal aspects and cellular localization (1998) J. Leukocyte Biol., 64, pp. 393-400
dc.descriptionRosmaraki, E.E., Douagi, I., Roth, C., Colucci, F., Cumano, A., Di Santo, J.P., Identification of committee NK cell progenitors in adult murine bone marrow (2001) Eur. J. Immunol., 31, pp. 1900-1909
dc.descriptionSharma, R., Bulmer, D., Peel, S., Effects of exogenous progesterone following ovariectomy on the metrial glands of pregnant mice (1986) J. Anat., 144, pp. 189-199
dc.descriptionSteinle, A., Li, P., Morris, D.L., Groh, V., Lanier, L.L., Strong, R.K., Spies, T., Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family (2001) Immunogenetics, 53, pp. 279-287
dc.descriptionStewart, I.J., Webster, A.J., Lectin histochemical studies of mouse granulated metrial gland cells (1997) Histochem. J., 29, pp. 885-892
dc.descriptionTakeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Akira, S., Defective NK cell activity and Th1 response in IL-18-deficient mice (1998) Immunity, 8, pp. 383-390
dc.descriptionTrinchieri, G., Proinflammatory and immunoregulatory functions of interleukin-12 (1998) Int. Rev. Immunol., 16, pp. 365-396
dc.descriptionUmans, L., Serneels, L., Overbergh, L., Stas, L., Van Leuven, F., Alpha2-macroglobulin- and murinoglobulin-1-deficient mice. A mouse model for acute pancreatitis (1999) Am. J. Pathol., 155, pp. 983-993
dc.descriptionWaldmann, T.A., Tagay, Y., The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens (1999) Annu. Rev. Immunol., 17, pp. 19-49
dc.descriptionWalker, W., Aste-Amezaga, M., Kastelein, R.A., Trinchieri, G., Hunter, C.A., IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma (1999) J. Immunol., 162, pp. 5894-5901
dc.descriptionYe, W., Zheng, L.M., Young, J.D., Liu, C.C., The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus (1996) J. Exp. Med., 84, pp. 2405-2410
dc.descriptionYokoyama, W.M., Seaman, W.E., The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: The NK gene complex (1993) Annu. Rev. Immunol., 11, pp. 613-635
dc.descriptionZhang, J.H., He, H., Borzychowski, A.M., Takeda, K., Akira, S., Croy, B.A., Analysis of cytokine regulators inducing IFN-γ production by mouse uterine natural killer cells (2003) Biol. Reprod., , in press
dc.descriptionZou, Z., Nomura, M., Takihara, Y., Yasunaga, T., Shimada, K., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: A novel cDNA family encodes cell surface proteins haring partial homology with MHC class I molecules (1996) J. Biochem., 119, pp. 319-328
dc.languageen
dc.publisher
dc.relationJournal of Reproductive Immunology
dc.rightsfechado
dc.sourceScopus
dc.titleUpdate On Pathways Regulating The Activation Of Uterine Natural Killer Cells, Their Interactions With Decidual Spiral Arteries And Homing Of Their Precursors To The Uterus
dc.typeActas de congresos


Este ítem pertenece a la siguiente institución