Artículos de revistas
Helicobacter Pylori: Phenotypes, Genotypes And Virulence Genes
Registro en:
Future Microbiology. , v. 4, n. 2, p. 223 - 240, 2009.
10.2217/17460913.4.2.223
2-s2.0-63849236851
Autor
Proenca-Modena J.L.
Acrani G.O.
Brocchi M.
Institución
Resumen
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucus overlying the epithelium of the stomach in more than 50% of the world's population. This gastric colonization induces chronic gastric inflammation in all infected individuals, but only induces clinical diseases in 10-20% of infected individuals. These include peptic ulcers, acute and atrophic gastritis, intestinal metaplasia, gastric adenocarcinoma and gastric B-cell lymphoma. Various bacterial virulence factors are associated with the development of such gastric diseases, and the characterization of these markers could aid medical prognosis, which could be extremely important in predicting clinical outcomes. 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