Hemoglobin Disorders And Endothelial Cell Interactions

dc.creatorConran N.
dc.creatorCosta F.F.
dc.date2009
dc.date2015-06-26T13:34:22Z
dc.date2015-11-26T14:59:24Z
dc.date2015-06-26T13:34:22Z
dc.date2015-11-26T14:59:24Z
dc.date.accessioned2018-03-28T22:10:57Z
dc.date.available2018-03-28T22:10:57Z
dc.identifierClinical Biochemistry. , v. 42, n. 18, p. 1824 - 1838, 2009.
dc.identifier10.1016/j.clinbiochem.2009.06.024
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-70449726798&partnerID=40&md5=448d6d9ac161e35cd43a476281cb335b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91941
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91941
dc.identifier2-s2.0-70449726798
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1256038
dc.descriptionEndothelial damage and inflammation make a significant contribution to the pathophysiology of sickle cell disease (SCD) and the β-thalassemia syndromes. Endothelial dysfunction and ensuing vasculopathy are implicated in pulmonary hypertension in the hemoglobinopathies and endothelial activation and endothelial-blood cell adhesion, accompanied by inflammatory processes and oxidative stress, are imperative to the vaso-occlusive process in SCD. Herein, we discuss the role that the endothelium plays in all of these processes and the effect that genetic modifiers and hydroxyurea therapy may have upon endothelial interactions. Therapies targeting the endothelium and endothelial interactions may represent a promising approach for treating these diseases. © 2009 The Canadian Society of Clinical Chemists.
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dc.relationClinical Biochemistry
dc.rightsfechado
dc.sourceScopus
dc.titleHemoglobin Disorders And Endothelial Cell Interactions
dc.typeArtículos de revistas


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