Clinical Influence Of Different Intracanal Medications On Th1-type And Th2-type Cytokine Responses In Apical Periodontitis

dc.creatorMartinho F.C.
dc.creatorNascimento G.G.
dc.creatorLeite F.R.M.
dc.creatorGomes A.P.M.
dc.creatorFreitas L.F.
dc.creatorCamoes I.C.G.
dc.date2015
dc.date2015-06-25T12:50:34Z
dc.date2015-11-26T14:57:56Z
dc.date2015-06-25T12:50:34Z
dc.date2015-11-26T14:57:56Z
dc.date.accessioned2018-03-28T22:09:43Z
dc.date.available2018-03-28T22:09:43Z
dc.identifier
dc.identifierJournal Of Endodontics. Elsevier Inc., v. 41, n. 2, p. 169 - 175, 2015.
dc.identifier992399
dc.identifier10.1016/j.joen.2014.09.028
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84921468507&partnerID=40&md5=f26b1c185ffb4053c449216d4dbff665
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85147
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85147
dc.identifier2-s2.0-84921468507
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255758
dc.descriptionIntroduction This clinical study assessed the influence of different intracanal medications on Th1-type and Th2-type cytokine responses in apical periodontitis and monitored the levels of bacteria from primarily infection during endodontic procedures. Methods Thirty primarily infected teeth were randomly divided into 3 groups according to the medication selected: chlorhexidine (CHX), 2% CHX gel; Ca(OH)2/SSL, Ca(OH)2 + SSL; and Ca(OH)2/CHX, Ca(OH)2 + 2% CHX gel (all, n = 10). Bacterial sample was collected from root canals, and the interstitial fluid was sampled from lesions. Culture techniques were used to determine bacterial counts (colony-forming units/mL). Th1 (tumor necrosis factor-α, interferon-γ, and interleukin [IL]-2) and Th2 cytokines (IL-4, IL-5, and IL-13) were measured by enzyme-linked immunosorbent assay. Results All intracanal medication protocols were effective in reducing the bacterial load from root canals (all P <.05) and lowering the levels of Th1-type cytokines in apical lesions (all P <.05), with no differences between them (P >.05). Both Ca(OH)2 treatment protocols significantly increased the levels of Th2-type cytokines (P <.05), with no differences between them (P >.05). Thus, chlorhexidine medication showed the lowest effectiveness in increasing the levels of Th2-type cytokine. After treatment, regardless of the type of medication, the linear regression analysis indicated the down-regulation of Th2-type cytokines by Th1-type cytokines. Conclusions All intracanal medication protocols were effective in reducing bacterial load and lowering the levels of Th1-type cytokines. Thus, the use of Ca(OH)2 medications contributed to the increase in the Th2-type cytokine response in apical periodontitis.
dc.description41
dc.description2
dc.description169
dc.description175
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dc.languageen
dc.publisherElsevier Inc.
dc.relationJournal of Endodontics
dc.rightsfechado
dc.sourceScopus
dc.titleClinical Influence Of Different Intracanal Medications On Th1-type And Th2-type Cytokine Responses In Apical Periodontitis
dc.typeArtículos de revistas


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