Pisco is a traditional beverage from Peru (South America) produced by the fermentation of pisco grapes. This article discusses the by-products of pisco production as a potential source of bioactive compounds; until now, pisco bagasse has had no industrial application. There is a knowledge gap that is the result of the lack of qualitative and quantitative information in the literature about the by-product of pisco production. Thus, we focus on the benefits that may be obtained with pisco by-product recovery, utilizing a literature review - including articles and patents - of the by-product generated in the production of wine and of the differences between the pisco and wine processes. This article analyzes the chemical composition, the biological activity and the major uses of pisco by-product, in addition to the applications for and biological activity of the extracts obtained through different extraction methods. © 2013 Bentham Science Publishers.714150(2012), http://apps.who.int/ghodata/?vid=10012, World Health Organization [Online]. Available, Accessed: Oct. 20Sharan, R.N., Odyuo, M.M., Purkayastha, S., Oxygen Free Radicals and Their Biomedical Implications: A Mini Review (2011) Mini-Rev Org Chem, 8, pp. 372-376. , NovemberParedes-López, O., Cervantes-Ceja, M.L., Vigna-Pérez, M., Hernández-Pérez, T., Berries: Improving human health and healthy aging, and promoting quality life-a review (2010) Plant Foods For Hum Nutr, 65, pp. 299-308. , SeptemberLafka, T.I., Sinanoglou, V., Lazos, E.S., On the extraction and antioxidant activity of phenolic compounds from winery wastes (2007) Food Chem, 104, pp. 1206-1214Szajdek, A., Borowska, E.J., Bioactive compounds and healthpromoting properties of Berry fruits: A review (2008) Plant Foods For Hum Nutr, 63, pp. 147-153. , DecemberAlcoholic Beverage: Pisco, Requirements (2006) Indecopi Norma Técnica, 211, p. 001(2012), http://www.oiv.int/oiv/info/enstatoivextracts2, OIV. StatOIV Extracts. Available Online, Accessed: Jul. 15(2012), http://faostat.fao.org/site/339/default.aspx, FAO. Countries by Commodity. Available Online, Accessed: May. 11(2008) Report of Grape Producers Registration In the Regions of Ica, Arequipa, Tacna and Lima Provinces, , Statistics, Ministry of Agriculture of Peru, Peru, Report September(2012) Vinicultura Y Elaboración De Pisco, , http://www.elpiscoesdelperu.com/boletines/julio2009/conociendo_pisco.htm, Elpiscoesdelperu.com, Available Online, Accessed: Sept. 14Rovira, F., (1966) La Industria Del Pisco En El Perú, , Peru: Instituto Nacional de Promoción Industrial, Banco IndustrialPerea, C.J., (1999) El Pisco: Tiene Sabor Peruano, , Peru: MITINCI Industriada Silva, L.R.L.M., Caracterização dos subprodutos da vinificação (2003) Revista Millenium, 28, pp. 123-133. , http://www.ipv.pt/millenium/millenium28/10.pdf, [Online]. Available From, Accessed: May. 11Huertas, V.L., Historia de la producción de vinos y piscos en el Perú (2004) Universum (Talca), 19, pp. 44-61(2012), http://www.sunat.gob.pe/estadisticasestudios/index.html, SUNAT. Available Online, Accessed: Jun. 13Farias-Campomanes, A.M., (2012) Recovery of Bioactive Compounds By Supercritical and Conventional Extraction From Grape Wastes of Pisco Industry, , M. Eng. thesis, Food Engineering Department, University of Campinas, BrazilBustamante, M.A., Moral, R., Paredes, C., Pérez-Espinosa, A., Moreno-Caselles, J., Pérez-Murcia, M.D., Agrochemical characterisation of the solid by-products and residues from the winery and distillery industry (2008) Waste Management, 28, pp. 372-380Jin, B., Kelly, J.M., Wine industry residues (2009) Biotechnology For Agro-Industrial Residues Utilisation: Utilisation of Agro-Residues, pp. 293-311. , P. S.-N. Nigam and A. Pandey, Eds., 1 ed: Springer NetherlandsDevesa-Rey, R., Vecino, X., Varela-Alende, J.L., Barral, M.T., Cruz, J.M., Moldes, A.B., Valorization of winery waste vs. the costs of not recycling (2011) Waste Management, 31, pp. 2327-2335. , NovemberChamy, R., Pizarro, C., Vivanco, E., Schiappacasse, M.C., Jeison, D., Poirrier, P., Ruiz-Filippi, G., Selected experiences in Chile for the application of UASB technology for vinasse treatment (2007) Water Sci Technol, 56, pp. 39-48Schieber, A., Stintzing, F.C., Carle, R., By-products of plant food processing as a source of functional compounds - recent developments (2001) Trends In Food Sci Technol, 12, pp. 401-413. , NovemberLouli, V., Ragoussis, N., Magoulas, K., Recovery of phenolic antioxidants from wine industry by-products (2004) Bioresource Technol, 92, pp. 201-208. , AprilPrado, J.M., Dalmolina, I., Cararetoa, N.D.D., Bassoa, R.C., Meirellesa, A.J.A., Oliveirab, J.V., Batistaa, E.A.C., Meireles, M.A.A., Supercritical fluid extraction of grape seed: Process scale-up, extract chemical composition and economic evaluation (2012) J Food Eng, 109, pp. 249-257. , MarchMaier, T., Schieber, A., Kammerer, D.R., Carle, R., Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidants (2009) Food Chem, 112, pp. 551-559. , FebruaryCheng, V.J., Bekhita, A.E.-A., McConnellb, M., Mrosb, S., Zhaoc, J., Effect of extraction solvent, waste fraction and grape variety on the antimicrobial and antioxidant activities of extracts from wine residue from cool climate (2012) Food Chem, 134, pp. 474-482. , SeptemberCasazza, A.A., Aliakbarian, B., Perego, P., Recovery of phenolic compounds from grape seeds: Effect of extraction time and solidliquid ratio (2011) Nat Product Res, 25, pp. 1751-1761Çetin, E.S., Altinoz, D., Tarcan, E., Baydar, N.G., Chemical composition of grape canes (2011) Ind Crops Prod, 34, pp. 994-998. , JulyCruz, J.M., Domínguez, H., Parajó, J.C., Assessment of the production of antioxidants from winemaking waste solids (2004) J Agr Food Chem, 52, pp. 5612-5620. , SeptemberMelo, P.S., Phenolic composition and antioxidant activity of agroindustrial residues (2011) Ciencia Rural, 41, pp. 1088-1093. , JuneXia, E.Q., Deng, G.F., Guo, Y.J., Li, H.B., Biological Activities of Polyphenols from Grapes (2010) Int J Mol Sci, 11, pp. 622-646. , FebruaryCastillo-Sanchez, J.X., García-Falcónc, M.S., Garridob, J., Martínez-Carballoc, E., Martins-Diasa, L.R., Mejutoc, X.C., Phenolic compounds and colour stability of vinhao wines: Influence of wine-making protocol and fining agents (2008) Food Chem, 106, pp. 18-26. , JanuaryGurbuz, O., Göçmen, D.F.D., Gürsoy, S., Aydin, S.M., Büyükuysal, L., Usta, M., Determination of flavan-3-ols and trans-resveratrol in grapes and wine using HPLC with fluorescence detection (2007) Food Chem, 100, pp. 518-525Yilmaz, Y., Toledo, R.T., Oxygen radical absorbance capacities of grape/wine industry byproducts and effect of solvent type on extraction of grape seed polyphenols (2006) J. Food Composition Anal, 19, pp. 41-48. , FebruarySagdic, O., Ozturka, I., Ozkanb, G., Yetima, H., Ekicia, L., Yilmazc, M.T., RP-HPLC-DAD analysis of phenolic compounds in pomace extracts from five grape cultivars: Evaluation of their antioxidant, antiradical and antifungal activities in orange and apple juices (2011) Food Chem, 126, pp. 1749-1758. , JuneBernardo-Gil, M.G., Ribeiro, M.A., Esquível, M.M., Produção de extractos para a indústria alimentar: Uso de fluidos supercríticos (2002) Boletim De Biotecnologia, 73, pp. 14-21Casazza, A.A., Aliakbariana, B., Mantegnab, G., Cravottob, S., Perego, P., Extraction of phenolics from Vitis vinifera wastes using non-conventional techniques (2010) J. Food Eng, 100, pp. 50-55. , SeptemberNegro, C., Tommasi, L., Miceli, A., Phenolic compounds and antioxidant activity from red grape marc extracts (2003) Bioresource Technol, 87, pp. 41-44. , MarchXu, C.M., Zhang, Y.L., Cao, L., Lu, J., Phenolic compounds and antioxidant properties of different grape cultivars grown in China (2010) Food Chem, 119, pp. 1557-1565. , AprilXu, C., Zhang, Y., Wang, J., Lu, J., Extraction, distribution and characterisation of phenolic compounds and oil in grapeseeds (2010) Food Chem, 122, pp. 688-694. , OctoberSpigno, G., Faveri, D.M., Antioxidants from grape stalks and marc: Influence of extraction procedure on yield, purity and antioxidant power of the extracts (2007) J Food Eng, 78, pp. 793-801. , FebruaryEikani, M.H., Golmohammad, F., Optimized Superheated hexane extraction of grapeseed oil (2009) J Food Lipids, 16, pp. 514-523. , NovemberBaydar, N.G., Ozkan, G., Yasar, S., Evaluation of the antiradical and antioxidant potential of grape extracts (2007) Food Control, 18, pp. 1131-1136. , SeptemberAleksovski, S., Sovová, H., Urapova, B., Poposka, F., Supercritical CO2 extraction and soxhlet extraction of grape seeds oil (1998) Bulletin of the Chemists and Technologists of Macedonia, 17, pp. 129-134de Campos, L.M.A.S., Leimann, F.V., Pedrosa, R.C., Ferreira, S.R.S., Free radical scavenging of grape pomace extracts from Cabernet sauvingnon (Vitis vinifera) (2008) Bioresource Technol, 99, pp. 8413-8420. , NovemberCasas, L., Mantell, C., Rodríguez, M., de la Ossa, M.E.J., Roldán, A., de Ory, I., Caro, I., Blandino, A., Extraction of resveratrol from the pomace of Palomino fino grapes by supercritical carbon dioxide (2010) J. Food Eng, 96, pp. 304-308. , JanuaryMurga, R., Ruiz, R., Beltran, S., Cabezas, J.L., Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol (2000) J. Agr Food Chem, 48, pp. 3408-3412. , AugustLeal, P.F., Kfouria, M.B., Alexandrea, F.C., Fagundesb, F.H.R., Pradoa, J.M., Toyamab, M.H., Meireles, M.A.A., Brazilian Ginseng extraction via LPSE and SFE: Global yields, extraction kinetics, chemical composition and antioxidant activity (2010) J. Supercrit. Fluids, 54, pp. 38-45. , JulyAlbuquerque, C.L.C., Meireles, M.A.A., Defatting of annatto seeds using supercritical carbon dioxide as a pretreatment for the production of bixin: Experimental, modeling and economic evaluation of the process (2012) J Supercrit Fluids, 66, pp. 86-95. , JuneMeireles, M.A.A., Extraction of Bioactive Compounds from Latin American Plants (2008) Supercritical Fluid Extraction of Nutraceuticals and Bioactive Compounds, pp. 243-274. , J. L. Martínez, Ed., ed Boca Raton: CRC Press-Taylor and Francis GroupEckert, P., Heinen, W., Knaudt, C., (2002) Cleaning and Cold-pressing of Grapeseed to Give Products of High Cyclic Polyphenol Content For Use In Foods, Fodders, Medicaments and Cosmetics, , E.P. Patent WO Patent 200110987AEP 1190024-AWO Patent 200110987A1DE Patent 19936492-A1AU Patent 200069905-ADE Patent 10015006-A1EP1190024-A1EP1190024-B1DE Patent 50000508-GHU Patent 200202395A2JP Patent 2003506072-WES Patent 2182809-T3ZA Patent 200200888ANZ Patent 517027AAU Patent 781016-B2U.S. Patent 7226627-B1. CA Patent 2382037CGuzman, N.C.A., Antonio, E.G.N.C., (2011) Obtaining Phenolic Compound Extract From Grape Pomace Vitis Vinifera At Low Temperatures By Obtaining Juice Extract and Residue Extract, Pressing Residue Extract, and Mixing Juice Extract and Pressed Juice to Obtain Phenolic Compound, , WO Patent 2011062468A2MX.2009012494-A1WO 2011062468-A3Huang, D.J., Ke, Y., (2010) Extracting and Separating Polyphenol From Plant, Involves Mixing Water and Hydrophilic Organic Solvent With Polyphenol-contained Plant Raw Materials and Heating Material to Obtain Filtrate By Solid-liquid Separation, , CN Patent 101838292-AWang, G., (2011) Preparing Grape Seed Extract Useful For Preparing Grape Seed Oil, By Separating Grape Residue From Grape Juice Production Process, Extracting Residue Using Alcohol and Water, Concentrating Extract and Drying Condensed Concentrate, , CN Patent 102228256-AMoro, G.C., (2009) Extracting Polyphenol From Grape Pomace, Involves Distilling Grape and Treating it With Ethanol and Water to Form Solution, " Which is Cooled, Filtered and Centrifuged For Removing Solid Precipitate, , ES Patent 2319032A1ES Patent 2319032B1Cho, Y.J., Kim, C.J., Kim, C.T., Oh, H.J., (2010) Extraction of Polyphenol Useful For Preventing and Treating E.g. Aging and Exhibiting Neuroprotective Effect, By Extracting Grape Branch With Organic Solvent, Filtering Extract and Evaporating Organic Solvent From Filtrate, , KR Patent 2010049209AKR Patent 1068890B1Shrikhande, A.J., Wang, H., Kupina, S.A., (2010) Making Polyphenol Extract From Grapes Comprises Contacting Member E.g. Whole Grapes With Water At An Elevated Temperature to Obtain Crude Grape-water Extract, and Treating Extract With Tannase Enzyme E.g. Yeast At An Elevated Temperature, , U.S. Patent 2010297741A1U.S. Patent 8075929-B2(2001) Red Grape Extract For Preventing and Treating Cancer, is Obtained By Extracting Red Grape and Contains Polyphenol As Active Constituent, , J.P. Patent 2001097872-AAngeletti, M., Sparapani, L., (2005) Grape Seed Extraction From Vitis Vinifera Grapes For Producing Grape Seed Oil Or As Food Additive Or Integrator, By Immediate Separation of Skin and Seeds After Work Up to Which Grapes Have Been Subjected, to Avoid And/or Stop Fermentation, , WO Patent 2005036988A1EP Patent 1677629-A1JP Patent 2007508006WU.S. Patent 2007134354A1IT Patent 1345026BFisher, L.A., Ianiro, T.T., Mergens, W.J., (2010) Muscadine Pomace Extract Composition Having Specific Polyphenol Content Useful For Preventing Cellular Aging and Inhibiting Oxidative Stress Comprises Bronze Muscadine Pomace Extract and Purple Muscadine Extract In Specific Weight Ratio, , WO Patent 2010014873A2WO Patent 2010014873-A3CA Patent 2732426-A1MX Patent 2011001183-A1U.S. Patent 2011177183A1CN Patent 102164607AJP Patent 2011529909W