The Role Of The Inflammatory Microenvironment In Thyroid Carcinogenesis

dc.creatorCunha L.L.
dc.creatorMarcello M.A.
dc.creatorWard L.S.
dc.date2014
dc.date2015-06-25T17:59:15Z
dc.date2015-11-26T14:56:49Z
dc.date2015-06-25T17:59:15Z
dc.date2015-11-26T14:56:49Z
dc.date.accessioned2018-03-28T22:08:46Z
dc.date.available2018-03-28T22:08:46Z
dc.identifierEndocrine-related Cancer. , v. 21, n. 3, p. R85 - R103, 2014.
dc.identifier10.1530/ERC-13-0431
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903592057&partnerID=40&md5=bde417579170ddd36e85f90f12f10d5b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87331
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87331
dc.identifier2-s2.0-84903592057
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255538
dc.descriptionImmune responses against thyroid carcinomas have long been demonstrated and associations between inflammatory microenvironment and thyroid carcinomas repeatedly reported. This scenario has prompted scientists throughout the world to unveil how the inflammatory microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with thyroid carcinoma. Many studies have reported the role of evasion from the immune system in tumor progression and reinforced the weakness of the innate immune response toward thyroid cancer spread in advanced stages. Translational studies have provided evidence that an increased density of tumor-associated macrophages in poorly differentiated thyroid carcinoma (DTC) is associated with an aggressive phenotype at diagnosis and decreased cancer-related survival, whereas well-DTC microenvironment enriched with macrophages is correlated with improved disease-free survival. It is possible that these different results are related to different microenvironments. Several studies have provided evidence that patients whose tumors are not infiltrated by lymphocytes present a high recurrence rate, suggesting that the presence of lymphocytes in the tumor microenvironment may favor the prognosis of patients with thyroid carcinoma. However, the effect of lymphocytes and other immune cells on patient outcome seems to result from complex interactions between the tumor and immune system, and the molecular pattern of cytokines and chemokines helps to explain the involvement of the immune system in thyroid tumor progression. The inflammatory microenvironment may help to characterize aggressive tumors and to identify patients who would benefit from a more invasive approach, probably sparing the vast majority of patients with an indolent disease from unnecessary procedures. © 2014 Society for Endocrinology.
dc.description21
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dc.descriptionR85
dc.descriptionR103
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dc.relationEndocrine-Related Cancer
dc.rightsfechado
dc.sourceScopus
dc.titleThe Role Of The Inflammatory Microenvironment In Thyroid Carcinogenesis
dc.typeArtículos de revistas


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