Artículos de revistas
A Comparative Study Of Principal Component And Linear Multiple Regression Analysis In Sar And Qsar Applied To 1,4-dihydropyridine Calcium Channel Antagonists (nifedipine Analogues)
Registro en:
Journal Of Molecular Structure: Theochem. , v. 394, n. 02/03/15, p. 291 - 300, 1997.
1661280
2-s2.0-0001463281
Autor
Costa M.C.A.
Gaudio A.C.
Takahata Y.
Institución
Resumen
The method of principal component analysis was shown to be capable of classifying 1,4-dihydropyridine derivatives into high active and low active groups for various different sets of compounds. Mainly quantum chemical parameters were used with this method. The kind of parameters employed by the method were found to be different to those employed by linear multiple regression analysis for identical sets of compounds. © 1997 Elsevier Science B.V. 394 02/03/15 291 300 Fukunaga, K., Koonz, W.L.G., (1970) IEEE Trans. Comp., 19 C, p. 311 Kowalski, B.R., Bender, C.F., (1972) J. Am. Chem. Soc., 9, p. 5632 Niemiin, G.J., (1990) Practical Applications of Quantitative Structure-activity Relationships (QSAR) in Environmental Chemistry and Toxicology, p. 153. , W. Karcher and J. Devilers (Eds.), Kluwer Academic Publishers, Dordrecht Janis, R.A., Silver, P.J., Triggle, D.J., (1987) Adv. Drug. Res., 16, p. 309 Seidel, W., Meyer, H., Born, L., Kazda, S., Dompert, W., (1985) Proc. of the 5th European Symp. of Quantitative Structure-activity Relationships, p. 366. , J.K. Seidel (Ed.), QSAR and Strategies in the Design of Bioactive Compounds, VCH Weinheim Berntsson, P., Wold, S., (1986) Quant. Struct.-Act. Relat., 5, p. 45 Mahmodian, M., Richards, W.G., (1986) J. Pharm. Pharmacol., 38, p. 272 Baldwin, J.J., Claremon, D.A., Lumma, P.K., McClure, D.E., Rosenthal, S.A., Winquist, R.J., Faison, E.P., Smith, G.M., (1987) J. Med. Chem., 30, p. 690 Fossheim, R., Joslyn, A., Solo, A.J., Luchowski, E., Rutledge, A., Triggle, D.J., (1988) J. Med. Chem., 31, p. 300 Coburn, R.A., Wierzba, M., Suto, M., Solo, A.J., Triggle, A.M., Triggle, D.J., (1998) J. Med. Chem., 31, p. 2103 Höltje, H.-D., Marrer, S., (1988) Quant. Struct.-Act. Relat., 7, p. 174 Mahmoudian, M., Richards, W.G., (1990) J. Sci. 1. R. Iran, 1, p. 261 Höltje, H.-D., (1992) Quant. Struct.-Act. Relat., 11, p. 224 Gaudio, A.C., Korolkovas, A., Takahata, Y., (1994) J. Pharm. Sci., 83, p. 1110 Dewar, M.J.S., Zoebisch, E.G., Healy, E.F., Stewart, J.J.P., (1985) J. Am. Chem. Soc., 107, p. 3902 Scarminio, I.S., Bruns, R.E., (1989) Trends Anal. Chem., 8, p. 326