Structural Brain Abnormalities Are Related To Retinal Nerve Fiber Layer Thinning And Disease Duration In Neuromyelitis Optica Spectrum Disorders

dc.creatorVon Glehn F.
dc.creatorJarius S.
dc.creatorCavalcanti Lira R.P.
dc.creatorAlves Ferreira M.C.
dc.creatorVon Glehn F.H.R.
dc.creatorCosta E Castro S.M.
dc.creatorBeltramini G.C.
dc.creatorBergo F.P.
dc.creatorFarias A.S.
dc.creatorBrandao C.O.
dc.creatorWildemann B.
dc.creatorDamasceno B.P.
dc.creatorCendes F.
dc.creatorSantos L.M.B.
dc.creatorYasuda C.L.
dc.date2014
dc.date2015-06-25T17:51:27Z
dc.date2015-11-26T14:56:06Z
dc.date2015-06-25T17:51:27Z
dc.date2015-11-26T14:56:06Z
dc.date.accessioned2018-03-28T22:08:09Z
dc.date.available2018-03-28T22:08:09Z
dc.identifier
dc.identifierMultiple Sclerosis. Sage Publications Ltd, v. 20, n. 9, p. 1189 - 1197, 2014.
dc.identifier13524585
dc.identifier10.1177/1352458513519838
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84897935386&partnerID=40&md5=50f796786bfcfb88eb45429832d7e669
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86066
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86066
dc.identifier2-s2.0-84897935386
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255417
dc.descriptionBackground: Although aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO. Objective: This study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness. Methods: Twenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed. Results: We demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease. Conclusions: Our findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. However, the presence atrophy encompassing almost all lobes suggests that additional pathomechanisms might also be involved. © The Author(s) 2014 Reprints and permissions:.
dc.description20
dc.description9
dc.description1189
dc.description1197
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dc.languageen
dc.publisherSAGE Publications Ltd
dc.relationMultiple Sclerosis
dc.rightsfechado
dc.sourceScopus
dc.titleStructural Brain Abnormalities Are Related To Retinal Nerve Fiber Layer Thinning And Disease Duration In Neuromyelitis Optica Spectrum Disorders
dc.typeArtículos de revistas


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