Increased Circulating Pedf And Low Sicam-1 Are Associated With Sickle Cell Retinopathy

dc.creatorCruz P.R.S.
dc.creatorLira R.P.C.
dc.creatorPereira Filho S.A.C.
dc.creatorSouza B.B.
dc.creatorMitsuushi F.N.
dc.creatorMenaa F.
dc.creatorFertrin K.Y.
dc.creatorVasconcellos J.P.C.
dc.creatorConran N.
dc.creatorCosta F.F.
dc.creatorMelo M.B.
dc.date2014
dc.date2015-06-25T17:51:07Z
dc.date2015-11-26T14:55:35Z
dc.date2015-06-25T17:51:07Z
dc.date2015-11-26T14:55:35Z
dc.date.accessioned2018-03-28T22:07:42Z
dc.date.available2018-03-28T22:07:42Z
dc.identifier
dc.identifierBlood Cells, Molecules, And Diseases. , v. , n. , p. - , 2014.
dc.identifier10799796
dc.identifier10.1016/j.bcmd.2014.08.003
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906302345&partnerID=40&md5=04f9fbc8f7777418151869b91b49b812
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85987
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85987
dc.identifier2-s2.0-84906302345
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255360
dc.descriptionSickle cell retinopathy (SCR) develops in up to 30% of sickle cell disease patients (SCD) during the second decade of life. Treatment for this affection remains palliative, so studies on its pathophysiology may contribute to the future development of novel therapies. SCR is more frequently observed in hemoglobin SC disease and derives from vaso-occlusion in the microvasculature of the retina leading to neovascularization and, eventually, to blindness. Circulating inflammatory cytokines, angiogenic factors, and their interaction may contribute to the pathophysiology of this complication. Angiopoietin (Ang)-1, Ang-2, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule (ICAM)-1, E-selectin, P-selectin, IL1-β, TNF-α, pigment epithelium derived factor (PEDF) and vascular endothelial growth factor plasmatic levels were determined in 37 SCD patients with retinopathy, 34 without retinopathy, and healthy controls. We observed that sICAM-1 is significantly decreased, whereas PEDF is elevated in HbSC patients with retinopathy (P = 0.012 and P = 0.031, respectively). Ang-1, Ang-2 and IL1-β levels were elevated in SCD patients (P = 0.001, P < 0.001 and P = 0.001, respectively), compared to controls, and HbSS patients presented higher levels of Ang-2 compared to HbSC (P < 0.001). Our study supports the possible influence of sICAM-1 and PEDF on the pathophysiology of retinal neovascularization in SCD patients. © 2014 Elsevier Inc. All rights reserved.
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dc.languageen
dc.publisher
dc.relationBlood Cells, Molecules, and Diseases
dc.rightsfechado
dc.sourceScopus
dc.titleIncreased Circulating Pedf And Low Sicam-1 Are Associated With Sickle Cell Retinopathy
dc.typeArtículos de revistas


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