Mammographic Breast Density In Women With Premature Ovarian Failure: A Prospective Analysis

dc.creatorBenetti-Pinto C.L.
dc.creatorBrancalion M.F.
dc.creatorAssis L.H.
dc.creatorTinois E.
dc.creatorGiraldo H.P.D.
dc.creatorCabello C.
dc.creatorYela D.A.
dc.date2014
dc.date2015-06-25T17:51:04Z
dc.date2015-11-26T14:55:32Z
dc.date2015-06-25T17:51:04Z
dc.date2015-11-26T14:55:32Z
dc.date.accessioned2018-03-28T22:07:38Z
dc.date.available2018-03-28T22:07:38Z
dc.identifier
dc.identifierMenopause. Lippincott Williams And Wilkins, v. 21, n. 9, p. 933 - 937, 2014.
dc.identifier10723714
dc.identifier10.1097/GME.0000000000000204
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84906938148&partnerID=40&md5=04571987d4c066534d7f5ac191e8e326
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85973
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85973
dc.identifier2-s2.0-84906938148
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1255351
dc.descriptionObjective: This study aims to compare breast density between two mammograms in women with premature ovarian failure (POF). Methods: A cohort study evaluated 56 women with POF. Two mammograms performed at least 2 years apart were analyzed. Mammogram films were digitalized, and images were assessed using a computer-assisted method; the percentage of breast image that is radiologically dense is referred to as the percentage of mammographic density (PMD). Age at menarche, age at onset of POF, length of POF, length of estrogen-progestin therapy (EPT), body mass index (BMI), pregnancy, and age at the time of each mammogram were evaluated. Results: The mean (SD) age at POF diagnosis was 32.35 (5.95) years. In the first mammogram, the mean (SD) age, BMI, and length of POF were 37.58 (3.72) years, 26.79 (4.86) kg/m, and 5.25 (4.61) years, respectively. EPT had been used for a mean (SD) of 2.71 (3.12) years. In the second mammogram, the mean (SD) age, BMI, and length of POF were 43.23 (4.98) years, 27.6 (5.39) kg/m, and 10.5 (5.11) years, respectively. EPT had been used for a mean (SD) of 7.25 (4.6) years. The mean (SD) interval between mammograms was 5.25 (3) years, and the mean (SD) PMD decreased from 27.78% (21.04%) to 17.53% (15.71%) (P = 0.007). Comparing PMD between women taking EPT and those not taking EPT, we observed no significant differences. In both instances, multiparous women had lower PMD than nulliparous women (P < 0.05). BMI, length of POF, and pregnancy were negatively correlated with PMD. Conclusions: Breast density in young women with POF decreases across a period of 5 years, regardless of EPT use. Further studies may elucidate how this result will correlate with decision-making in clinical therapeutics and breast cancer risk in POF. © 2014 by The North American Menopause Society.
dc.description21
dc.description9
dc.description933
dc.description937
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dc.languageen
dc.publisherLippincott Williams and Wilkins
dc.relationMenopause
dc.rightsfechado
dc.sourceScopus
dc.titleMammographic Breast Density In Women With Premature Ovarian Failure: A Prospective Analysis
dc.typeArtículos de revistas


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