Early Potential Impairment Of Renal Sensory Nerves In Streptozotocin- Induced Diabetic Rats: Role Of Neurokinin Receptors

dc.creatorBoer P.A.
dc.creatorRossi C.D.L.
dc.creatorMesquita F.F.
dc.creatorGontijo J.A.R.
dc.date2011
dc.date2015-06-30T20:41:27Z
dc.date2015-11-26T14:53:38Z
dc.date2015-06-30T20:41:27Z
dc.date2015-11-26T14:53:38Z
dc.date.accessioned2018-03-28T22:05:33Z
dc.date.available2018-03-28T22:05:33Z
dc.identifier
dc.identifierNephrology Dialysis Transplantation. , v. 26, n. 3, p. 823 - 832, 2011.
dc.identifier9310509
dc.identifier10.1093/ndt/gfq512
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79952131875&partnerID=40&md5=d517153f550d629d26a374ceb008663a
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108897
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108897
dc.identifier2-s2.0-79952131875
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254995
dc.descriptionBackground: Electrophysiological studies in the mammalian kidney have identified two major classes of sensory receptors of the afferent renal nerves; chemoreceptors (CR) and mechanoreceptors (MR). The localization of calcitonin gene-related peptide (CGRP) and substance P (SP) in these renal pelvic sensory neurons provides an anatomical basis for a possible functional interaction between the two neuropeptides and SP receptor. The present study was performed to examine the possible changes in the responsiveness of renal sensory SP and CGRP receptors in rats with streptozotocin (STZ)-induced diabetes mellitus. Due to the crucial role of renal pelvic SP and CGRP receptors in the activation of renal sensory neurons by various stimuli, we examined whether the responsiveness of MR or CR activation and the dorsal root ganglia content of neuropeptides and neurokinin 1 receptors (NK1R) were altered in diabetic rats compared with non-diabetic rats.Methods. Afferent renal nerve activity (ARNA) was recorded from the peripheral portion of the cut end of one renal nerve branch placed on a bipolar silver wire electrode. T13 dorsal root ganglia (DRG) immunoreactivity was performed to NK1R, SP and CGRP.Results. The results of the current study confirmed that the stimulation of renal MR and CR elicited a renorenal reflex response, and that the renal pelvic administration of SP and CGRP increased ipsilateral ARNA and contralateral urinary sodium excretion with no changes in arterial pressure. We also found a decrease in NK1R expression followed by an increase in SP and CGRP levels in the DRG of diabetic rats. The ARNA response, produced by renal pelvic MR and CR stimulation, was found to be significantly attenuated in the STZ-induced diabetic model.Conclusions. These data may indicate a compensatory synthesis and/or abnormal axonal delivery of neurokinins from the cell body to synaptic portions of the neuron as the underlying reason for attenuated ARNA in renal sensory neurons of diabetic rats. © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
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dc.relationNephrology Dialysis Transplantation
dc.rightsfechado
dc.sourceScopus
dc.titleEarly Potential Impairment Of Renal Sensory Nerves In Streptozotocin- Induced Diabetic Rats: Role Of Neurokinin Receptors
dc.typeArtículos de revistas


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