Risk Estimates For Persistent High-risk Human Papillomavirus Infections As Surrogate Endpoints Of Progressive Cervical Disease Critically Depend On Reference Category: Analysis Of The Combined Prospective Cohort Of The New Independent States Of The Former Soviet Union And Latin American Screening Studies

dc.creatorSyrjanen K.
dc.creatorShabalova I.
dc.creatorNaud P.
dc.creatorKozachenko V.
dc.creatorDerchain S.
dc.creatorZakharchenko S.
dc.creatorRoteli-Martins C.
dc.creatorNerovjna R.
dc.creatorLongatto-Filho A.
dc.creatorKljukina L.
dc.creatorTatti S.
dc.creatorBranovskaja M.
dc.creatorHammes L.S.
dc.creatorBranca M.
dc.creatorGrunjberga V.
dc.creatorErzen M.
dc.creatorJuschenko A.
dc.creatorCosta S.
dc.creatorSarian L.
dc.creatorPodistov J.
dc.creatorSyrjanen S.
dc.date2011
dc.date2015-06-30T20:41:42Z
dc.date2015-11-26T14:53:23Z
dc.date2015-06-30T20:41:42Z
dc.date2015-11-26T14:53:23Z
dc.date.accessioned2018-03-28T22:05:19Z
dc.date.available2018-03-28T22:05:19Z
dc.identifier
dc.identifierInternational Journal Of Std And Aids. , v. 22, n. 6, p. 315 - 323, 2011.
dc.identifier9564624
dc.identifier10.1258/ijsa.2009.009365
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79959518571&partnerID=40&md5=b86722322f500d28639be6c094925da7
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108915
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108915
dc.identifier2-s2.0-79959518571
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254956
dc.descriptionTo make feasible future clinical trials with new-generation human papillomavirus (HPV) vaccines, novel virological surrogate endpoints of progressive disease have been proposed, including high-risk HPV (HR-HPV) persistence for six months (6M+) or 12 months (12M+). The risk estimates (relative risks [RRs]) of these 'virological endpoints' are influenced by several variables, not yet validated adequately. We compared the impact of three referent groups: (i) HPV-negative, (ii) HPV-transient, (iii) HPV-mixed outcome on the risk estimates for 6M+ or 12M+ HR-HPV persistence as predictors of progressive disease. Generalized estimating equation models were used to estimate the strength of 6M+ and 12M+ HR-HPV persistence with disease progression to squamous intraepithelial lesions (SILs), cervical intraepithelial neoplasia (CIN) grade 1+, CIN2+, CIN/SIL endpoints, comparing three optional reference categories (i)-(iii) in a prospective sub-cohort of 1865 women from the combined New Independent States of the Former Soviet Union (NIS) and Latin American Screening (LAMS) studies cohort (n = 15,301). The RRs of these viral endpoints as predictors of progressive disease are affected by the length of viral persistence (6M+ or 12M+) and the surrogate endpoint (SIL, CIN1, CIN2, CIN/SIL). Most dramatic is the effect of the referent group used in risk estimates, with the HPV-negative referent group giving the highest and most consistent RRs for both 6M+ and 12M+ viral persistence, irrespective of which surrogate is used. In addition to deciding on whether to use 6M+ or 12M+ persistence criteria, and cytological, histological or combined surrogate endpoints, one should adopt the HPVnegative referent group as the gold standard in all future studies using viral persistence as the surrogate endpoint of progressive disease.
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dc.languageen
dc.publisher
dc.relationInternational Journal of STD and AIDS
dc.rightsfechado
dc.sourceScopus
dc.titleRisk Estimates For Persistent High-risk Human Papillomavirus Infections As Surrogate Endpoints Of Progressive Cervical Disease Critically Depend On Reference Category: Analysis Of The Combined Prospective Cohort Of The New Independent States Of The Former Soviet Union And Latin American Screening Studies
dc.typeArtículos de revistas


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