Amyloidosis is a generic term that refers to the deposition of amyloid fibrils in bodily tissues. Its onset is usually after 40 years of age, with localized or systemic involvement associated with multiple myeloma or chronic inflammatory diseases, and can mimic various rheumatic syndromes. We report the case of a patient with amyloidosis associated with multiple myeloma, showing clinical characteristics of pseudomyopathy. © 2011 Elsevier Editora Ltda. All rights reserved.516648654Prokaeva, T., Spencer, B., Kaut, M., Ozonoff, A., Doros, G., Connors, L.H., Soft tissue, joint, and bone manifestations of AL amyloidosis: Clinical presentation, molecular features, and survival (2007) Arthritis Rheum, 56 (11), pp. 3858-3868Merlini, G., Bellotti, V., Molecular mechanisms of amyloidosis (2003) N Engl J Med, 349 (6), pp. 583-596Scola, R.H., Werneck, L.C., Ramos, C.S., Pasquini, R., Graf, H., Arruda, W.O., Amyloidotic muscle pseudohypertrofy: Case Report (2001) Arq Neuropsiquiatr, 59 (A-3), pp. 582-586Simms, R.W., Prout, M.N., Cohen, A.S., The epidemiology of AL and AA amyloidosis (1994) Baillieres Clin Rheumatol, 8 (3), pp. 627-634Gerster, J.C., Landry, M., Dudler, J., Scleroderma-like changes of the hands in primary amyloidosis (2000) J Rheumatol, 27 (9), pp. 2275-2277Fujishima, M., Komatsuda, A., Imai, H., Wakui, H., Watanabe, W., Sawada, K., Amyloid arthropathy resembling seronegative rheumatoid arthritis in a patient with IgD-κ multiple myeloma (2003) Intern Med, 42 (1), pp. 121-124Gertz, M.A., Kyle, R.A., Myopathy in primary systemic amyloidosis (1996) J Neurol Neurosurg Psychiatry, 60 (6), pp. 655-660Gogel, H.K., Searles, R.P., Volpicelli, N.A., Cornwell, G.G., Primary amyloidosis presenting as Sjögren's syndrome (1983) Arch Intern Med, 143 (12), pp. 2325-2326Schlesinger, I., Multiple myeloma and AL amyloidosis mimicking Sjögren's syndrome (1993) South Med J, 86 (5), pp. 568-569Bortoli, R., Lima, I.V.S., Queiroz, A.C., Santiago, M.B., Amiloidose manifestando-se com pseudo-hipertrofia muscular (2007) Rev Bras Reumatol, 47 (6), pp. 455-457Criteria for the classifcation of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group (2003) Br J Haematol, 121 (5), pp. 749-757. , International Myeloma Working GroupLafforgue, P., Senbel, E., Figarella-Branger, D., Boucraut, J., Horschowsky, N., Pellissier, J.F., Systemic amyloidosis AL with temporal artery involvement revealing lymphoplasmacytic malignancy in a man presenting as polymyalgia rheumatica (1993) Ann Rheum Dis, 52 (2), pp. 158-160Kyle, R.A., Greipp, P.R., Amyloidosis (AL).Clinical and laboratory features in 229 case (1983) Mayo Clin Pro, 58 (10), pp. 665-683Bukhari, M., Freemont, A.J., Noble, J., Jayson, M.I., Erosive amyloidosis of the wrist and knee associated with oligoclonal bands (1997) Br J Rheumatol, 36 (4), pp. 494-497Gertz, M.A., Lacy, M.Q., Dispenzieri, A., Hayman, S.R., Amyloidosis: Diagnosis and management (2005) Clin Lymphoma Myeloma, 6 (3), pp. 208-219