Histological And Functional Renal Alterations Caused By Bothrops Alternatus Snake Venom: Expression And Activity Of Na+/k+-atpase

dc.creatorLinardi A.
dc.creatorRocha E Silva T.A.A.
dc.creatorMiyabara E.H.
dc.creatorFranco-Penteado C.F.
dc.creatorCardoso K.C.
dc.creatorBoer P.A.
dc.creatorMoriscot A.S.
dc.creatorGontijo J.A.R.
dc.creatorJoazeiro P.P.
dc.creatorCollares-Buzato C.B.
dc.creatorHyslop S.
dc.date2011
dc.date2015-06-30T20:38:41Z
dc.date2015-11-26T14:52:40Z
dc.date2015-06-30T20:38:41Z
dc.date2015-11-26T14:52:40Z
dc.date.accessioned2018-03-28T22:04:41Z
dc.date.available2018-03-28T22:04:41Z
dc.identifier
dc.identifierBiochimica Et Biophysica Acta - General Subjects. , v. 1810, n. 9, p. 895 - 906, 2011.
dc.identifier3044165
dc.identifier10.1016/j.bbagen.2011.06.006
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79960736088&partnerID=40&md5=642ca65302b72096b75e56d9aa6d0ae5
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108766
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108766
dc.identifier2-s2.0-79960736088
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254853
dc.descriptionBackground: Acute renal failure is a serious complication of human envenoming by Bothrops snakes. The ion pump Na+/K+-ATPase has an important role in renal tubule function, where it modulates sodium reabsorption and homeostasis of the extracellular compartment. Here, we investigated the morphological and functional renal alterations and changes in Na+/K+-ATPase expression and activity in rats injected with Bothrops alternatus snake venom. Methods: Male Wistar rats were injected with venom (0.8 mg/kg, i.v.) and renal function was assessed 6, 24, 48 and 72 h and 7 days post-venom. The rats were then killed and renal Na+/K +-ATPase activity was assayed based on phosphate release from ATP; gene and protein expressions were assessed by real time PCR and immunofluorescence microscopy, respectively. Results: Venom caused lobulation of the capillary tufts, dilation of Bowman's capsular space, F-actin disruption in Bowman's capsule and renal tubule brush border, and deposition of collagen around glomeruli and proximal tubules that persisted seven days after envenoming. Enhanced sodium and potassium excretion, reduced proximal sodium reabsorption, and proteinuria were observed 6 h post-venom, followed by a transient decrease in the glomerular filtration rate. Gene and protein expressions of the Na+/K+-ATPase α1 subunit were increased 6 h post-venom, whereas Na+/K +-ATPase activity increased 6 h and 24 h post-venom. Conclusions: Bothrops alternatus venom caused marked morphological and functional renal alterations with enhanced Na+/K+-ATPase expression and activity in the early phase of renal damage. General significance: Enhanced Na+/K+-ATPase activity in the early hours after envenoming may attenuate the renal dysfunction associated with venom-induced damage. © 2011 Elsevier B.V. All rights reserved.
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dc.languageen
dc.publisher
dc.relationBiochimica et Biophysica Acta - General Subjects
dc.rightsfechado
dc.sourceScopus
dc.titleHistological And Functional Renal Alterations Caused By Bothrops Alternatus Snake Venom: Expression And Activity Of Na+/k+-atpase
dc.typeArtículos de revistas


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