Perinatal Exposure To Parasiticide Ivermectin: Long-term Effects On Reproductive Parameters Of Adult Male Rats

dc.creatorTerneux E.W.A.
dc.creatorPontes D.A.
dc.creatorFernandez C.D.B.
dc.creatorArena A.C.
dc.creatorPorto E.M.
dc.creatorde Kempinas W.G.
dc.date2011
dc.date2015-06-30T20:38:15Z
dc.date2015-11-26T14:52:26Z
dc.date2015-06-30T20:38:15Z
dc.date2015-11-26T14:52:26Z
dc.date.accessioned2018-03-28T22:04:29Z
dc.date.available2018-03-28T22:04:29Z
dc.identifier
dc.identifierToxicological And Environmental Chemistry. , v. 93, n. 2, p. 345 - 351, 2011.
dc.identifier2772248
dc.identifier10.1080/02772248.2010.523930
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78649828380&partnerID=40&md5=92f14f9b9a07cbb9ef03166c60ab712b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108736
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108736
dc.identifier2-s2.0-78649828380
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254817
dc.descriptionIvermectin is one of the most widely used antiparasitic drugs globally. The aim of this study was to evaluate the chronic effects of perinatal exposure to ivermectin on male reproductive parameters in rats. Pregnant rats were treated daily by oral gavage with 0.4 or 1.6 mg kg -1 of ivermectin or vehicle, from gestational day 6 until post-natal day 10. In the adulthood stage, there were significant reductions in the relative testicular weight of rats exposed to the low dose and in relative prostate weight of male rats exposed to the high dose of ivermectin. Furthermore, the animals exposed to the low dose also presented an increased seminal vesicle weight compared to controls. However, neither of the ivermectin doses interfered in daily sperm production, sperm number in testis, or sexual behavior of exposed males. In conclusion, perinatal exposure to ivermectin neither altered the male reproductive system development markedly, nor produced any adverse effects on the parameters evaluated. © 2011 Taylor & Francis.
dc.description93
dc.description2
dc.description345
dc.description351
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dc.languageen
dc.publisher
dc.relationToxicological and Environmental Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titlePerinatal Exposure To Parasiticide Ivermectin: Long-term Effects On Reproductive Parameters Of Adult Male Rats
dc.typeArtículos de revistas


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