| dc.creator | Queiroz M.L.S. | |
| dc.creator | da Rocha M.C. | |
| dc.creator | Torello C.O. | |
| dc.creator | de Souza Queiroz J. | |
| dc.creator | Bincoletto C. | |
| dc.creator | Morgano M.A. | |
| dc.creator | Romano M.R. | |
| dc.creator | Paredes-Gamero E.J. | |
| dc.creator | Barbosa C.M.V. | |
| dc.creator | Calgarotto A.K. | |
| dc.date | 2011 | |
| dc.date | 2015-06-30T20:38:18Z | |
| dc.date | 2015-11-26T14:52:24Z | |
| dc.date | 2015-06-30T20:38:18Z | |
| dc.date | 2015-11-26T14:52:24Z | |
| dc.date.accessioned | 2018-03-28T22:04:27Z | |
| dc.date.available | 2018-03-28T22:04:27Z | |
| dc.identifier | | |
| dc.identifier | Food And Chemical Toxicology. , v. 49, n. 11, p. 2934 - 2941, 2011. | |
| dc.identifier | 2786915 | |
| dc.identifier | 10.1016/j.fct.2011.06.056 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-80053565969&partnerID=40&md5=721e009415156757254a20dbd2f244c7 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/108739 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/108739 | |
| dc.identifier | 2-s2.0-80053565969 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1254815 | |
| dc.description | Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit +Lin -), granulocyte-macrophage progenitors (Gr1 +Mac1 +) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV. © 2011 Elsevier Ltd. | |
| dc.description | 49 | |
| dc.description | 11 | |
| dc.description | 2934 | |
| dc.description | 2941 | |
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| dc.language | en | |
| dc.publisher | | |
| dc.relation | Food and Chemical Toxicology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Chlorella Vulgaris Restores Bone Marrow Cellularity And Cytokine Production In Lead-exposed Mice | |
| dc.type | Artículos de revistas | |
