Protective Effect Of Guaraná (paullinia Cupana Var. Sorbilis) Pre-treatment On Cadmium-induced Damages In Adult Wistar Testis

dc.creatorLeite R.P.
dc.creatorWada R.S.
dc.creatorMonteiro J.C.
dc.creatorPredes F.S.
dc.creatorDolder H.
dc.date2011
dc.date2015-06-30T20:37:42Z
dc.date2015-11-26T14:52:09Z
dc.date2015-06-30T20:37:42Z
dc.date2015-11-26T14:52:09Z
dc.date.accessioned2018-03-28T22:04:09Z
dc.date.available2018-03-28T22:04:09Z
dc.identifier
dc.identifierBiological Trace Element Research. , v. 141, n. 01/03/15, p. 262 - 274, 2011.
dc.identifier1634984
dc.identifier10.1007/s12011-010-8729-7
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79959611692&partnerID=40&md5=4fb20c66481af37f5928ec9c17ce23a6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/108689
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/108689
dc.identifier2-s2.0-79959611692
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254747
dc.descriptionGuaraná (Paullinia cupana) is an Amazonian plant. Its antioxidant potential was demonstrated to be due to the high polyphenol concentration. On the other hand, one of the mechanisms underlying cadmium-induced cellular damage is free radical mediated, resulting in increased oxidative processes. This study investigated P. cupana's potential to attenuate cadmium-induced damages in Wistar rat testis. Adult male Wistar rats were either pre-treated with 2 mg/g body weight (BW) of powdered P. cupana seed during 56 days and/or injected with cadmium chloride at a dose of 1.15 mg/kg BW. After cadmium exposition (48 h), testes samples were evaluated by histological and stereological analyses. Both groups exposed to cadmium presented evident morphological alterations relative to control animals. A few rodents showed massive cell death in the seminiferous epithelium and intertubular space, indicating that some animals are more sensitive to cadmium. Despite the alterations observed in both groups, pre-treatment with P. cupana was effective in attenuating morphological changes in Leydig cells, as well as reducing inflammatory response, relative to animals exclusively exposed to the metal. Animals treated only with P. cupana presented a significant increase in plasma testosterone levels and a significant increase in volumetric proportions of seminiferous tubules, which are indicative of spermatogenic stimulation. © 2010 Springer Science+Business Media, LLC.
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dc.languageen
dc.publisher
dc.relationBiological Trace Element Research
dc.rightsfechado
dc.sourceScopus
dc.titleProtective Effect Of Guaraná (paullinia Cupana Var. Sorbilis) Pre-treatment On Cadmium-induced Damages In Adult Wistar Testis
dc.typeArtículos de revistas


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