Artículos de revistas
Pilot-scale Synthesis And Rheological Assessment Of Poly(methyl Methacrylate) Polymers: Perspectives For Medical Application
Registro en:
Materials Science And Engineering C. Elsevier Ltd, v. 51, n. , p. 107 - 116, 2015.
9284931
10.1016/j.msec.2015.02.038
2-s2.0-84924076173
Autor
Linan L.Z.
Nascimento Lima N.M.
Filho R.M.
Sabino M.A.
Kozlowski M.T.
Manenti F.
Institución
Resumen
This work presents the rheological assessment of poly(methyl methacrylate) (PMMA) polymers synthesized in a dedicated pilot-scale plant. This material is to be used for the construction of scaffolds via Rapid Prototyping (RP). The polymers were prepared to match the physical and biological properties required for medical applications. Differential Scanning Calorimetry (DSC) and Size Exclusion Chromatography (SEC) measurements verified that the synthesized polymers were atactic, amorphous and linear in chains. Rheological properties such as viscosity, storage and loss modulus, beyond the loss factor, and creep and recovery were measured in a plate-plate sensor within the viscoelastic linear region. The results showed the relevant influence of the molecular weight on the viscosity and elasticity of the material, and how, as the molecular weight increases, the viscoelastic properties are getting closer to those of human bone. This article demonstrates that by using the implemented methodology it is possible to synthesize a polymer, with properties comparable to commercially-available PMMA. 51
107 116 Frazer, R.Q., Byron, R.T., Osborne, P.B., West, K.P., PMMA: An essential material in medicine and dentistry (2005) J. Long-Term Eff. Med. Implants, 15, pp. 629-639 Dalosto, V.J., (2005) Sintese e Caracterização Do Poli (L - Ácido Láctico) Para Uso Como Biomaterial, , http://www.lume.ufrgs.br/bitstream/handle/10183/6945/000492758.pdf?%851, Departamento de Engenharia de Materiais, Escola de Engenharia. Universidade Federal do Rio Grande do Sul Porto Alegre (79 p. These (In Portuguese). Retrieved from:< >. Accessed in Sep 30 2014) De Almeida, S.G., (2005) Biomateriais. Forum de Biotecnologia de Materiais, , http://www.redetec.org.br/publique/media/tr10_biomateriais.pdf, (In Portuguese) (Accessed in May 05 2013, Retrieved from:) Espalin, D., Arcaute, K., Rodriguez, D., Medina, F., Fused deposition modeling of patient-specific polymethylmethacrylate implants (2010) Rapid Prototyp. J., 16, pp. 164-173 Kretlow, J.D., Shi, M., Young, S., Spicer, P.P., Demian, N., Jansen, J.A., Wong, M.E., Mikos, A., Evaluation of soft tissue coverage over porous polymethylmethacrylate space maintainers within nonhealing alveolar bone defects (2010) Tissue Eng. Part C Methods, 16, pp. 1427-1438 Santos, J.G.F., Peixoto, L.S., Nele, M., Melo, P.A., Pinto, J.C., Theoretical and experimental investigation of the production of PMMA-based bone cement (2006) Macromol. Symp., 243, pp. 1-12 Stańczyk, M., Study on modelling of PMMA bone cement polymerization (2005) J. Biomech., 38, pp. 1397-1403 Kim, B., Hong, K., Park, K., Park, D., Chung, Y., Kang, S., Customized cranioplasty implants using three-dimensional printers and polymethyl-methacrylate casting (2012) J. Korean Neurosurg. Soc., 52, pp. 541-546 Liulan, L., Qingxi, H., Xianxu, H., Gaochun, X., Design and fabrication of bone tissue engineering scaffolds via rapid prototyping and CAD (2007) J. Rare Earths, 25, pp. 379-383 Salmoria, G.V., Leite, J.L., Lopes, C.N., Machado, R.A.F., Lago, A., The manufacturing of PMMA/OS blends by selective laser sintering (2008) Virtual and Rapid Manufacturing, pp. 305-311. , P.J. Bartolo, Taylor & Francis Group London Chang, J., Lai, J., Computation of optimal temperature policy for molecular weight control in a batch polymerization reactor (1992) Ind. Eng. Chem. Res., 31, pp. 861-868 Rho, H., Huh, Y., Rhee, H., Application of adaptive model-predictive control to a batch MMA polymerization reactor (1998) Chem. Eng. Sci., 53, pp. 3729-3739 Chang, J., Liao, P., Molecular weight control of a batch polymerization reactor: Experimental study (1999) Ind. Eng. Chem. Res., 38, pp. 144-153 Pahija, E., Manenti, F., Mujtaba, I.M., Selecting the best control methodology to improve the efficiency of discontinuous reactors (2013) Computer Aided Chemical Engineering, pp. 805-810. , A. Kraslawski, I. Turunen, Elsevier Amsterdam Lima, N.M.N., Zuniga, L.L., Maciel Filho, R., Wolf Maciel, M.R., Embiruçu, M., Grácio, F., Modeling and predictive control using fuzzy logic: Application for a polymerization system (2010) AICHE J., 56, pp. 965-978 Antunes, A.J.B., Pereira, J.A.F.R., Fileti, A.M.F., Fuzzy control of a PMMA batch reactor: Development and experimental testing (2005) Comput. Chem. Eng., 30, pp. 268-276 Congalidis, J.P., Richards, J.R., Ray, W.H., Feedforward and feedback control of a solution copolymerization reactor (1989) AICHE J., 35, pp. 891-907 Mendes, R., (2006) Estudo Experimental Comparativo Dos Cimentos Ósseos Nacionais, , http://www.maxwell.lambda.ele.puc-rio.br/9823/9823_3.PDF, (Accessed in September 23 2014., M.Sc. Tese (In Portuguese). Retrieved from) Mousa, W.F., Kobayashi, M., Shinzato, S., Kamimura, M., Neo, M., Yoshihara, S., Nakamura, T., Biological and mechanical properties of PMMA-based bioactive bone cements (2000) Biomaterials, 21, pp. 2137-2146 Bruens, M.L., Pieterman, H., De Winjn, J.R., Vaandrager, J.M., Porous polymethylmethacrylate as bone substitute in the craniofacial area (2003) J. Craniofac. Surg., 14, pp. 63-68 Mano, J.F., Viscoelastic properties of bone: Mechanical spectroscopy studies on a chicken model (2005) Mater. Sci. Eng. C, 25, pp. 145-152 Ahn, S., Chang, S., Rhee, H., Application of optimal temperature trajectory to batch PMMA polymerization reactor (1998) J. Appl. Polym. Sci., 69, pp. 59-68 Zuniga, L.L., Lima, N.M.N., Tovar, L.P., Manenti, F., Maciel Filho, R., Wolf Maciel, M.R., Embiruçu, M., Pilot-plant simulation, experimental campaign and rigorous modeling of a batch MMA polymerization reactor for the fabrication of bone tissue (2012) Computer Aided Chemical Engineering, pp. 1352-1356. , I.D. Lockhart, M. Fairweather, Elsevier Amsterdam Lima, N.M.N., Zuniga, L.L., Manenti, F., Maciel Filho, R., Wolf Maciel, M.R., Embiruçu, M., Novel two-steps optimal control of batch polymerization reactors and application to PMMA production for the fabrication of artificial bone tissue (2013) Computer Aided Chemical Engineering, pp. 163-168. , A. Kraslawski, I. Turunen, Elsevier Amsterdam Muenstedt, H., Nikolaos, K., Kaschta, J., Rheological properties of poly(methyl methacrylate)/nanoclay composites as investigated by creep recovery in shear (2008) Macromolecules, 41, pp. 9777-9783 Tuminello, W.H., Molecular weight and molecular weight distribution from dynamic measurements of polymer melts (1986) Polym. Eng. Sci., 26, pp. 1339-1347 Fuchs, K., Friedrich, C., Weese, J., Viscoelastic properties of narrow-distribution poly(methylmethacrylate) (1996) Macromolecules, 29, pp. 5893-5901 Eckstein, A., Suhm, J., Friedrich, C., Maier, R.D., Sassmannshausen, J., Bochmann, M., Mülhaupt, R., Determination of plateau moduli and entanglement molecular weights of isotactic, syndiotactic, and atactic polypropylenes synthesized with metallocene catalysts (1998) Macromolecules, 31, pp. 1335-1340 Simon, P.F., Müller, A.H.E., Pakula, T., Characterization of highly branched poly(methyl methacrylate) by solution viscosity and viscoelastic spectroscopy (2001) Macromolecules, 34, pp. 1677-1684 Buechner, P.M., Lakes, R.S., Swan, C.S., Brand, R.A., A broadband viscoelastic spectroscopic study of bovine bone: Implications for fluid flow (2001) Ann. Biomed. Eng., 29, pp. 719-728 Fetters, L.J., Lohse, D.J., Milner, S.T., Graessley, W.W., Packing length influence in linear polymer melts on the entanglement, critical, and reputation molecular weights (1999) Macromolecules, 32, pp. 6847-6851