Impaired Incretin Secretion And Pancreatic Dysfunction With Older Age And Diabetes

dc.creatorGeloneze B.
dc.creatorDe Oliveira M.D.S.
dc.creatorVasques A.C.J.
dc.creatorNovaes F.S.
dc.creatorPareja J.C.
dc.creatorTambascia M.A.
dc.date2014
dc.date2015-06-25T17:57:14Z
dc.date2015-11-26T14:50:49Z
dc.date2015-06-25T17:57:14Z
dc.date2015-11-26T14:50:49Z
dc.date.accessioned2018-03-28T22:02:10Z
dc.date.available2018-03-28T22:02:10Z
dc.identifier
dc.identifierMetabolism: Clinical And Experimental. W.b. Saunders, v. 63, n. 7, p. 922 - 929, 2014.
dc.identifier260495
dc.identifier10.1016/j.metabol.2014.04.004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84902546110&partnerID=40&md5=62b5a6a5c0a1636e278546bdc3a65ac0
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87218
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87218
dc.identifier2-s2.0-84902546110
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1254272
dc.descriptionObjective To estimate the impact of aging and diabetes on insulin sensitivity, beta-cell function, adipocytokines, and incretin production. Methods Hyperglycemic clamps, arginine tests and meal tolerance tests were performed in 50 non-obese subjects to measure insulin sensitivity (IS) and insulin secretion as well as plasma levels of glucagon, GLP-1 and GIP. Patients with diabetes and healthy control subjects were divided into the following groups: middle-aged type 2 diabetes (MA-DM), aged Type 2 diabetes (A-DM) and middle-aged or aged subjects with normal glucose tolerance (MA-NGT or A-NGT). Results IS, as determined by the homeostasis model assessment, glucose infusion rate, and oral glucose insulin sensitivity, was reduced in the aged and DM groups compared with MA-NGT, but it was similar in the MA-DM and A-DM groups. Insulinogenic index, first and second phase insulin secretion and the disposition indices, but not insulin response to arginine, were reduced in the aged and DM groups. Postprandial glucagon production was higher in MA-DM compared to MA-NGT. Whereas the GLP-1 production was reduced in A-DM, no differences between groups were observed in GIP production. Conclusions In non-obese subjects, diabetes and aging impair insulin sensitivity. Insulin production is reduced by aging, and diabetes exacerbates this condition. Aging associated defects superimposed diabetic physiopathology, particularly regarding GLP-1 production. On the other hand, the glucose-independent secretion of insulin was preserved. Knowledge of the complex relationship between aging and diabetes could support the development of physiopathological and pharmacological based therapies. © 2014 Published by Elsevier Inc.
dc.description63
dc.description7
dc.description922
dc.description929
dc.descriptionChristensen, K., Doblhammer, G., Rau, R., Vaupel, J.W., Ageing populations: The challenges ahead (2009) Lancet, 3 (374), pp. 1196-1208
dc.descriptionLu, F.P., Lin, K.P., Kuo, H.K., Diabetes and the risk of multi-system aging phenotypes: A systematic review and meta-analysis (2009) PLoS One, 4, p. 4144
dc.descriptionWild, S., Roglic, G., Green, A., Sicree, R., King, H., Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030 (2004) Diabetes Care, 27, pp. 1047-1053
dc.descriptionNing, F., Qiao, Q., Tuomilehto, J., Hammar, N., Ho, S.Y., Söderberg, S., Does abnormal insulin action or insulin secretion explain the increase in prevalence of impaired glucose metabolism with age in populations of different ethnicities? (2010) Diabetes Metab Res Rev, 26, pp. 245-253
dc.descriptionScheen, A.J., Diabetes mellitus in the elderly: Insulin resistance and/or impaired insulin secretion? (2005) Diabetes Metab, , [Spec No 2:5S27-5S34]
dc.descriptionPalmer, J.P., Ensinck, J.W., Acute-phase insulin secretion and glucose tolerance in young and aged normal men and diabetic patients (1975) J Clin Endocrinol Metab, 41, pp. 498-503
dc.descriptionChang, A.M., Halter, J.B., Aging and insulin secretion (2003) Am J Physiol Endocrinol Metab, 284, pp. 7-E12
dc.descriptionIozzo, P., Beck-Nielsen, H., Laakso, M., Smith, U., Yki-Jarvinen, H., Ferrannini, E., Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance (1999) J Clin Endocrinol Metab, 84, pp. 863-868
dc.descriptionStumvoll, M., Meyer, C., Kreider, M., Perriello, G., Gerich, J., Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans (1998) Metabolism, 47, pp. 1227-1232
dc.descriptionMcConnell, J.G., Alam, M.J., O'Hare, M.M., Buchanan, K.D., Stout, R.W., The effect of age and sex on the response of enteropancreatic polypeptides to oral glucose (1983) Age Ageing, 12, pp. 54-62
dc.descriptionElahi, D., Andersen, D.K., Muller, D.C., Tobin, J.D., Brown, J.C., Andres, R., The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus (1984) Diabetes, 33, pp. 950-957
dc.descriptionMacintosh, C.G., Andrews, J.M., Jones, K.L., Wishart, J.M., Morris, H.A., Jansen, J.B., Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility (1999) Am J Clin Nutr, 69, pp. 999-1006
dc.descriptionRanganath, L., Sedgwick, I., Morgan, L., Wright, J., Marks, V., The ageing entero-insular axis (1998) Diabetologia, 41, pp. 1309-1313
dc.descriptionKorosi, J., McIntosh, C.H., Pederson, R.A., Demuth, H.U., Habener, J.F., Gingerich, R., Effect of aging and diabetes on the enteroinsular axis (2001) J Gerontol A Biol Sci Med Sci, 56, pp. 575-M579
dc.descriptionMeneilly, G.S., Ryan, A.S., Minaker, K.L., Elahi, D., The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin (1998) J Clin Endocrinol Metab, 83, pp. 2925-2932
dc.descriptionElahi, D., McAloon-Dyke, M., Fukagawa, N.K., Meneilly, G.S., Sclater, A.L., Minaker, K.L., The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects (1994) Regul Pept, 51, pp. 63-74
dc.descriptionStandards of medical care in diabetes - 2012 (2012) Diabetes Care, 35 (SUPPL. 1), pp. 11-S63. , American Diabetes Association
dc.descriptionEndocrinology & Metabolism. Diabetes Trial Unit. HOMA Calculator, , http://www.dtu.ox.ac.uk/, Oxford Centre For Diabetes [Acessed Dec 2012]
dc.descriptionMari, A., Pacini, G., Murphy, E., Ludvik, B., Nolan, J.J., A model-based method for assessing insulin sensitivity from the oral glucose tolerance test (2001) Diabetes Care, 24, pp. 539-548
dc.descriptionMari, A., Schmitz, O., Gastaldelli, A., Oestrgaard, T., Nyholm, B., Ferrannini, E., Meal and oral glucose tests for assessment of β-cell function: Modeling analysis in normal subjects (2002) Am J Physiol Endocrinol Metab, 283, pp. 1159-E1166
dc.descriptionWard, W.K., Bolgiano, D.C., McKnight, B., Halter, J.B., Porte, Jr.D., Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus (1984) J Clin Invest, 74, pp. 1318-1328
dc.descriptionKahn, S.E., Prigeon, R.L., McCulloch, D.K., Boyko, E.J., Bergman, R.N., Schwartz, M.W., Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function (1993) Diabetes, 42, pp. 1663-1672
dc.descriptionHuang, E.S., Liu, J.Y., Moffet, H.H., John, P.M., Karter, A.J., Glycemic control, complications, and death in older diabetic patients: The diabetes and aging study (2011) Diabetes Care, 34, pp. 1329-1336
dc.descriptionMeigs, J.B., Muller, D.C., Nathan, D.M., Blake, D.R., Andres, R., The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging (2003) Diabetes, 52, pp. 1475-1484
dc.descriptionRøder, M.E., Schwartz, R.S., Prigeon, R.L., Kahn, S.E., Reduced pancreatic B cell compensation to the insulin resistance of aging: Impact on proinsulin and insulin levels (2000) J Clin Endocrinol Metab, 85, pp. 2275-2280
dc.descriptionMeneilly, G.S., Eliott, T., Assessment of insulin sensitivity in older adults using the hyperglycemic clamp technique (1998) J Am Geriatr Soc, 46, pp. 88-91
dc.descriptionRadegran, G., Blomstrand, E., Saltin, B., Peak muscle perfusion and oxygen uptake in humans: Importance of precise estimates of muscle mass (1999) J Appl Physiol, 87, pp. 2375-2380
dc.descriptionFerrannini, E., Vichi, S., Beck-Nielsen, H., Laakso, M., Paolisso, G., Smith, U., Insulin action and age. European Group for the Study of Insulin Resistance (EGIR) (1996) Diabetes, 45, pp. 947-953
dc.descriptionCoon, P.J., Rogus, E.M., Drinkwater, D., Muller, D.C., Goldberg, A.P., Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age (1992) J Clin Endocrinol Metab, 75, pp. 1125-1132
dc.descriptionAhima, R.S., Connecting obesity, aging and diabetes (2009) Nat Med, 15, pp. 996-997
dc.descriptionKahn, S.E., The relative contributions of insulin resistance and beta-cell dysfunction to the physiopathology of type 2 diabetes (2003) Diabetologia, 46, pp. 3-19
dc.descriptionJensen, C.C., Cnop, M., Hull, R.L., Fujimoto, W.Y., Kahn, S.E., Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S (2002) Diabetes, 51, pp. 2170-2178. , Diabetes Association Gennid Study Group
dc.descriptionFritsche, A., Madaus, A., Stefan, N., Tschritter, O., Maerker, E., Teigeler, A., Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans (2002) Diabetes, 51 (SUPPL. 1), pp. 234-S239
dc.descriptionLund, A., Vilsbøll, T., Bagger, J.I., Holst, J.J., Knop, F.K., The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes (2011) Am J Physiol Endocrinol Metab, 300, pp. 1038-E1046
dc.descriptionVardarli, I., Köthe, L.D., Holst, J.J., Deacon, C.F., Theodorakis, M., Meier, J.J., GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. Mentis N (2011) Diabetes, 60, pp. 1270-1276
dc.descriptionLynn, F.C., Pamir, N., Ng, E.H., McIntosh, C.H., Kieffer, T.J., Pederson, R.A., Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats (2001) Diabetes, 50, pp. 1004-1011
dc.descriptionPernicova, I., Korbonitz, M., Metformin - Mode of action and clinical implications for diabetes and cancer (2014) Nat Rev Endocrinol, 10, pp. 143-156
dc.descriptionStumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., Gerich, J.E., Metabolic effects of metformin in non-insulin-dependet diabetes mellitus (1995) N Engl J Med, 333, pp. 550-554
dc.descriptionThondam, S.K., Cross, A., Cuthbertson, D.J., Wilding, J.P., Daousi, C., Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with type 2 diabetes mellitus (2012) Diabet Med, 29, pp. 205-e210
dc.descriptionSolis-Herrera, C., Triplitt, C., Garduno-Garcia, J.J., Adams, J., Defronzo, R.A., Cerosimo, E., Mehcanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes (2013) Diabetes Care, 36, pp. 2756-2762
dc.descriptionLindsay, J.R., Duffy, N.A., McKillop, A.M., Ardill, J., Óharte, F.P.M., Flatt, P.R., Inhibition of dipeptidyl peptidase IV activity by oral metformin in type 2 diabetes (2005) Diabet Med, 22, pp. 654-657
dc.descriptionCuthbertson, J., Patterson, S., Óharte, F.P.M., Bell, P.M., Investigation of the effect of oral metformin in dipeptidylpeptidase-4 (DPP-4) activity in type 2 diabetes (2009) Diabet Med, 26, pp. 649-654
dc.descriptionInouye, S.K., Studenski, S., Tinetti, M.E., Kuchel, G.A., Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept (2007) J Am Geriatr Soc, 55, pp. 780-791
dc.descriptionKnowler, W.C., Fowler, S.E., Hamman, R.F., Christophi, C.A., Hoffman, H.J., 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study (2009) Lancet, 374, pp. 1677-1686. , Prevention Program Research Group
dc.languageen
dc.publisherW.B. Saunders
dc.relationMetabolism: Clinical and Experimental
dc.rightsfechado
dc.sourceScopus
dc.titleImpaired Incretin Secretion And Pancreatic Dysfunction With Older Age And Diabetes
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución