dc.creator | Postal M. | |
dc.creator | Appenzeller S. | |
dc.date | 2011 | |
dc.date | 2015-06-30T20:31:30Z | |
dc.date | 2015-11-26T14:50:47Z | |
dc.date | 2015-06-30T20:31:30Z | |
dc.date | 2015-11-26T14:50:47Z | |
dc.date.accessioned | 2018-03-28T22:02:07Z | |
dc.date.available | 2018-03-28T22:02:07Z | |
dc.identifier | 9781617615528 | |
dc.identifier | Autoimmune Disorders: Symptoms, Diagnosis And Treatment. Nova Science Publishers, Inc., v. , n. , p. 167 - 190, 2011. | |
dc.identifier | | |
dc.identifier | | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84892022654&partnerID=40&md5=bf4298d252e53381d103435cfc0e2563 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/108228 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/108228 | |
dc.identifier | 2-s2.0-84892022654 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1254263 | |
dc.description | Systemic lupus erythematosus (SLE) is a multisystemic disease characterized by profound alterations of the immune system that contribute to inflammation and tissue damage. The diverse presentations of SLE range from rash and arthritis through anemia and thrombocytopenia to serositis, nephritis, seizures, and psychosis. SLE should be part of the differential diagnosis in virtually any patient presenting with one of these clinical problems, especially in female patients between 15 and 50 years of age. Since 90% of patients with SLE are female, an important role for sex hormones seems likely, but a protective role for male hormones is also possible. Pathogenic auto-antibodies are the primary cause of tissue damage in patients with SLE. The production of these antibodies arises by means of complex mechanisms involving every key facet of the immune system. There are no diagnostic criteria, only classification criteria. In order to consider SLE for research practice, the patient must present at least four of 11 criteria established by the American College of Rheumatology (ACR). Many different elements of the system are potential targets for therapeutic drugs in SLE. The treatment involves immunosuppressive medications like high-dose of corticosteroids, azathioprine, and cyclophosphamide. Mycophenolate mofetil and rituximab have been used in association with corticosteroids (oral or intravenous pulse therapy) in SLE patients. Besides, anti-malarial medications are used not only to control disease, but also to improve survival and to reduce the risk of thrombosis. The aim of this review is to describe symptoms of SLE that may vary from rash and arthritis through seizures, and psychosis. We will also include a review on current treatment and new medications. © 2011 Nova Science Publishers, Inc. All rights reserved. | |
dc.description | | |
dc.description | | |
dc.description | 167 | |
dc.description | 190 | |
dc.description | Grossman, J.M., Kenneth, C.K., Definition | |
dc.description | classification | |
dc.description | activity and damage indices (2002), In: Dubois' Lupus Erythematosus | |
dc.description | 6th ed. Lippincott | |
dc.description | Williams & Wilkins: Philadelphia | |
dc.description | PARahman, A., Isenberg, D.A., Systemic lupus erythematosus (2008) N Engl J Med., 358, pp. 929-939 | |
dc.description | Pons-Estel, G.J., Alarcón, G.S., Scofield, L., Understanding the epidemiology and progression of systemic lupus erythematosus (2010) Semin Arthritis Rheum., 39, p. 25768 | |
dc.description | Huemer, C., Huemer, M., Dorner, T., Incidence of pediatric rheumatic diseases in a regional population in Austria (2001) J Rheumatol., 28, pp. 2116-2119 | |
dc.description | Huang, J.L., Yao, T.C., See, L.C., Prevalence of pediatric systemic lupus erythematosus and juvenile chronic arthritis in a Chinese population: a nation-wide prospective population-based study in Taiwan (2004) Clin Exp Rheumatol., 22, pp. 776-780 | |
dc.description | Bae, S.C., Fraser, P., Liang, M.H., The epidemiology of systemic lupus erythematosus in populations of African ancestry: a critical review of the "prevalence gradient hypothesis" (1998) Arthritis Rheum., 41, pp. 2091-2099 | |
dc.description | McCarty, D.J., Manzi, S., Medsger Jr., T.A., Incidence of systemic lupus erythematosus. Race and gender differences (1995) Arthritis Rheum., 38, pp. 1260-1270 | |
dc.description | Johnson, A.E., Gordon, C., Palmer, R.G., Bacon, P.A., The prevalence and incidence of systemic lupus erythematosus in Birmingham | |
dc.description | England. Relationship to ethnicity and country of birth (1995) Arthritis Rheum., 38, pp. 551-558 | |
dc.description | Hopkinson, N.D., Doherty, M., Powell, R.J., The prevalence and incidence of systemic lupus erythematosus in Nottingham | |
dc.description | UK | |
dc.description | 1989-1990 (1993) Br J Rheumatol., 32, pp. 110-115 | |
dc.description | Chakravarty, E.F., Bush, T.M., Manzi, S., Prevalence of adult systemic lupus erythematosus in California and Pennsylvania in 2000, estimates obtained using hospitalization data (2007) Arthritis Rheum., 56, pp. 2092-2094 | |
dc.description | Samanta, A., Feehally, J., Roy, S., High prevalence of systemic disease and mortality in Asian subjects with systemic lupus erythematosus (1991) Ann Rheum Dis., 50, pp. 490-492 | |
dc.description | Hochberg, M.C., The incidence of systemic lupus erythematosus in Baltimore | |
dc.description | Maryland | |
dc.description | 1970-1977 (1985) Arthritis Rheum., 28, pp. 80-86 | |
dc.description | Bossingham, D., Systemic lupus erythematosus in the far north of Queensland (2003) Lupus., 12, pp. 327-331 | |
dc.description | Segasothy, M., Phillips, P.A., Systemic lupus erythematosus in Aborigines and Caucasians in central Australia: a comparative study (2001) Lupus., 10, pp. 439-444 | |
dc.description | Boyer, G.S., Templin, D.W., Lanier, A.P., Rheumatic diseases in Alaskan Indians of the southeast coast: high prevalence of rheumatoid arthritis and systemic lupus erythematosus (1991) J Rheumatol., 18, pp. 1477-1484 | |
dc.description | Peschken, C.A., Esdaile, J.M., Systemic lupus erythematosus in North American Indians: a population based study (2000) J Rheumatol., 27, pp. 1884-1891 | |
dc.description | Hochberg, M.C., Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus (1997) Arthritis Rheum., 40, p. 1725 | |
dc.description | Petri, M., Review of classification criteria for systemic lupus erythematosus (2005) Rheum Dis Clin North Am., 31, pp. 245-254 | |
dc.description | Tench, C.M., McCurdie, I., White, P.D., D'Cruz, D.P., The prevalence and associations of fatigue in systemic lupus erythematosus (2000) Rheumatology., 39, pp. 1249-1254. , (Oxford) | |
dc.description | Manson, J.J., Rahman, A., Systemic lupus erythematosus (2006) Orphanet J Rare Dis., 1, p. 6 | |
dc.description | Weening, J.J., D'Agati, V.D., Schwartz, M.M., The classification of glomerulonephritis in systemic lupus erythematosus revisited (2004) J Am Soc Nephrol., 15, pp. 241-250 | |
dc.description | West;, S.G., Neuropsychiatry lupus (1994) Rheum Dis Clin North Am., 20, pp. 129-158 | |
dc.description | Hanly;, J.G., Walsh, N.M., Sangalang;, V., Brain pathology in systemic lupus erythematosus (1992) J Rheumatol., 19, pp. 732-741 | |
dc.description | Johnson, R.T., Richardson, E.P., The neurological manifestations of systemic lupus erythematosus (1968) Medicine., 47, pp. 337-369. , (Baltimore) | |
dc.description | The American College of Rheumatology nomenclature and case definitions for neuropsychiatry lupus syndromes (1999) Arthritis Rheum., 42, pp. 599-608 | |
dc.description | Panopalis, P., Julian, L., Yazdany, J., Impact of memory impairment on employment status in persons with systemic lupus erythematosus (2007) Arthritis Rheum., 57, pp. 1453-1460 | |
dc.description | Sultan, S.M., Begum, S., Isenberg, D.A., Prevalence | |
dc.description | patterns of disease and outcome in patients with systemic lupus erythematosus who develop severe haematological problems (2003) Rheumatology., 42, pp. 230-234. , (Oxford) | |
dc.description | Ropes, M.W., (1976) Systemic lupus erythematosus., , Cambridge | |
dc.description | MA: Harvard University Press | |
dc.description | Fries, J.F., Holamn, H., Systemic lupus erythematosus: a clinica analysis (1975) Philadelphia: WB Saunders | |
dc.description | Uramoto, K.M., Michet, C.J., Thumboo, J., Trends in the incidence and mortality of systemic lupus erythematosus | |
dc.description | 1950-1992 (1999) Arthritis Rheum., 42, pp. 46-50 | |
dc.description | Paran, D., Fireman, E., Elkayam, O., Pulmonary disease in systemic lupus erythematosus and the antiphospholpid syndrome (2004) Autoimmun Rev., 3, pp. 70-75 | |
dc.description | Yeh, T.T., Yang, Y.H., Lin, Y.T., Lu, C.S., Chiang, B.L., Cardiopulmonary involvement in pediatric systemic lupus erythematosus: a twenty-year retrospective analysis (2007) J Microbiol Immunol Infect., 40, pp. 525-531 | |
dc.description | Szekanecz, Z., Shoenfeld, Y., Lupus and cardiovascular disease: the facts (2006) Lupus., S15, pp. 3-10 | |
dc.description | Jacobsen, S., Petersen, J., Ullman, S., A multicentre study of 513 Danish patients with systemic lupus erythematosus. II. Disease mortality and clinic factors of prognostic value (1998) Clin Rheumatol., 17, pp. 478-484 | |
dc.description | Law, W.G., Thong, B.Y., Lian, T.Y., Kong, K.O., Chng, H.H., Acute lupus myocarditis: clinical features and outcome of an oriental case series (2005) Lupus., 14, pp. 827-831 | |
dc.description | Tincani, A., Rebaioli, C.B., Taglietti, M., Shoenfeld, Y., Heart involvement in systemic lupus erythematosus | |
dc.description | anti-phospholipid syndrome and neonatal lupus (2006) Rheumatology., 45 (SUPPL. 4), pp. 48-13 | |
dc.description | Galli, M., Luciani, D., Bertolini, G., Barbui, T., Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature (2003) Blood., 101, pp. 1827-1832 | |
dc.description | Somers, E., Magder, L.S., Petri, M., Antiphospholipid antibodies and incidence of venous thrombosis in a cohort of patients with systemic lupus erythematosus (2002) J Rheumatol., 29, pp. 2531-2536 | |
dc.description | Sultan, S.M., Ioannou, Y., Isenberg, D.A., A review of gastrointestinal manifestations of systemic lupus erythematosus (1999) Rheumatology., 38, pp. 917-932. , (Oxford) | |
dc.description | Cervera, R., Khamashta, M.A., Font, J., Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1, 000 patients (2003) Medicine., 82, pp. 299-308. , (Baltimore) | |
dc.description | Fauci, A.S., Haynes, B., Katz, P., The spectrum of vasculitis: clinical | |
dc.description | pathologic | |
dc.description | immunologic and therapeutic considerations (1978) Ann Intern Med., 89, pp. 660-676 | |
dc.description | Ruiz-Irastorza, G., Lima, F., Alves, J., Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies (1996) Br J Rheumatol., 35, pp. 133-138 | |
dc.description | Ruiz-Irastorza, G., Khamashta, M., Hughes, G.R.V., Systemic lupus erythematosus and antiphospholipid syndrome during pregnancy: maternal and fetal complications and their management (2000) MAJ., 2, pp. 462-469 | |
dc.description | Rahman, P., Gladman, D.D., Urowitz, M.B., Clinical predictors of fetal outcome in systemic lupus erythematosus (1998) J Rheumatol., 25, pp. 1526-1530 | |
dc.description | Welsch, S., Branch, D.W., Antiphospholipid syndrome in pregnancy: obstetric concerns and treatment (1997) Rheum Dis Clin North Am., 23, pp. 71-84 | |
dc.description | Meng, C., Lockshin, M., Pregnancy in lupus (1999) Curr Opin Rheumatol., 11, pp. 348-351 | |
dc.description | Julkunen, H., Kaaja, R., Siren, M.K., Immune-mediated congenital heart block (CHB): identifying and counseling patients at risk for having children with CHB (1998) Semin Arthritis Rheum., 28, pp. 97-106 | |
dc.description | Wong, K.L., Chan, F.Y., Lee, C.P., Outcome of pregnancy in patients with systemic lupus erythematosus. A prospective study (1991) Arch Intern Med., 151, pp. 269-273 | |
dc.description | Bermas, B.L., Hill, J.A., Effects of immunosuppressive drugs during pregnancy (1995) Arthritis Rheum., 38, pp. 1722-1732 | |
dc.description | Wallace, D.J., Antimalarial agents and lupus (1994) Rheum Dis Clin North Am., 20, p. 24363 | |
dc.description | Walport, M.J., Black, C.M., Batchelor, J.R., The immunogenetics of SLE (1982) Clin Rheum Dis., 8, pp. 3-21 | |
dc.description | Sontheimer, R.D., Photoimmunology of lupus erythematosus and dermatomyositis: a speculative review (1996) Photochem Photobiol., 42, pp. 583-594 | |
dc.description | James, J.A., Kaufman, K.M., Farris, A.D., An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus (1997) J Clin Invest., 100, pp. 3019-3026 | |
dc.description | Levine, J.S., Koh, J.S., The role of apoptosis in autoimmunity: immunogen | |
dc.description | antigen and accelerant (1999) Semin Nephrology., 19, pp. 34-47 | |
dc.description | Huck, S., Deveaud, E., Namane, A., Abnormal DNA methylation and deoxycytosine content in nucleosomes from lymphocytes undergoing apoptosis (1999) FASEB. J, 3, pp. 1415-1422 | |
dc.description | Andrade, F., Cascioloa-Rosen, L., Rosen, A., Apoptosis in systemic lupus erythematosus. Clinical implications Rheum Dis Clin North Am., 26, pp. 215-227. , 200 | |
dc.description | Herrmann, M., Voll, R.E., Zoller, O.M., Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus (1998) Arthritis Rheum., 41, pp. 1241-1250 | |
dc.description | Mason, L.J., Isenberg, D., The pathogenesis of systemic lupus erythematosus (2005), pp. 809-829. , In: Oxford textbook of clinical nephrology | |
dc.description | 3rd ed Oxford | |
dc.description | England: Oxford University Press;Bynoe, M.S., Grimaldi, C.M., Diamond, B., Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells (2000) Proc Natl Acad Sci. USA, 97, pp. 2703-2708 | |
dc.description | Chang, D.M., Lan, J.L., Lin, H.Y., Luo, S.F., Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized | |
dc.description | double-blind | |
dc.description | placebo-controlled trial (2002) Arthritis Rheum., 46, pp. 2924-2927 | |
dc.description | Chrousos, G.P., The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation (1995) N Engl J Med., 332, pp. 1351-1362 | |
dc.description | Chan, O.T., Madaio, M.P., Sholmchik, M.J., The central and multiple roles of B cells in lupus pathogenesis (1999) Immunol Rev., 169, pp. 107-121 | |
dc.description | Holbrow, E.J., Weir, D.M., Jhonson, G.D., A serum factor in lupus erythematosus with affinity for tissue nuclei (1957) Br Med J., 2, pp. 732-734 | |
dc.description | Koffler, D., Schur, P.H., Kunkel, H.G., Immunological studies concerning the nephritis of systemic lupus erythematosus (1967) J Exp Med., 126, pp. 607-624 | |
dc.description | Isenberg, D.A., Shoenfeld, Y., Walport, M., Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives (1985) Arthritis Rheum., 28, pp. 999-1007 | |
dc.description | Ng, K.P., Manson, J.J., Rahman, A., Isenberg, D.A., Associations of antinucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus (2006) Arthritis Rheum., 55, pp. 900-904 | |
dc.description | Mannik, M., Merrill, C.E., Stamps, L.D., Wener, M.H., Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus (2003) J Rheumatol., 30, pp. 1495-1504 | |
dc.description | Buyon, J.P., Clancy, R.M., Maternal autoantibodies and congenital heart block: mediators | |
dc.description | markers | |
dc.description | and therapeutic approach (2003) Semin Arthritis Rheum., 33, pp. 140-154 | |
dc.description | Clancy, R.M., Kapur, R.P., Molad, Y., Immunohistologic evidence supports apoptosis | |
dc.description | IgG deposition | |
dc.description | and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block (2004) Arthritis Rheum., 50, pp. 173-182 | |
dc.description | Kowal, C., Degiorgio, L.A., Lee, J.Y., Human lupus autoantibodies against NMDA receptors mediate cognitive impairment (2006) Proc Natl Acad Sci U S A, 103, pp. 19854-19859 | |
dc.description | Elkon, K.B., Parnassa, A.P., Foster, C.R., Lupus autoantibodies target ribosomal P proteins (1985) J Exp Med., 162, pp. 459-471 | |
dc.description | Briani, C., Lucchetta, M., Ghirardello, A., Neurolupus is associated with anti-ribosomal P protein antibodies: an inception cohort study (2009) J Autoimmun., 32, p. 7984 | |
dc.description | Abdel-Nasser, A.M., Ghaleb, R.M., Mahmoud, J.A., Association of anti-ribosomal P protein antibodies with neuropsychiatry and other manifestations of systemic lupus erythematosus (2008) Clin Rheumatol., 27, pp. 1377-1385 | |
dc.description | Hirohata, S., Arinuma, Y., Takayama, M., Association of cerebrospinal fluid anti-ribosomal p protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus (2007) Arthritis Res Ther., 9, pp. R44 | |
dc.description | Tzioufas, A.G., Tzortzakis, N.G., Panou-Pomonis, E., The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease (2000) Ann Rheum Dis., 59, pp. 99-104 | |
dc.description | Chindalore, V., Neas, B., Reichlin, M., The association between anti-ribosomal P antibodies and active nephritis in systemic lupus erythematosus (1998) Clin Immunol Immunopathol., 87, pp. 292-296 | |
dc.description | Hulsey, M., Goldstein, R., Scully, L., Antiribosomal P protein antibodies in systemic lupus erythematosus: a case-control study correlating hepatic and renal disease (1995) Clin Immunol Immunopathol., 74, pp. 252-256 | |
dc.description | Monova, D., Argirova, T., Monov, S., Anti-ribosomal P antibodies in patients with lupus glomerulonephritis (2001) Clin Nephrol., 55, pp. 425-426 | |
dc.description | Arnett, F.C., Reichlin, M., Lupus hepatitis: an under-recognized disease feature associated with autoantibodies to ribosomal P (1995) Am J Med., 99, pp. 465-472 | |
dc.description | Koren, E., Schnitz, W., Reichlin, M., Concomitant development of chronic active hepatitis and antibodies to ribosomal P proteins in a patient with systemic lupus erythematosus (1993) Arthritis Rheum., 9, pp. 1325-1328 | |
dc.description | Koscec, M., Koren, E., Wolfson-Reichlin, M., Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture (1997) J Immunol., 159, pp. 2033-2041 | |
dc.description | Sontheimer, R.D., Maddison, P.J., Reichlin, M., Serologic and HLA associations in subacute cutaneous lupus erythematosus | |
dc.description | a clinical subset of lupus erythematosus (1982) Ann Intern Med., 97, pp. 664-671 | |
dc.description | Grootscholten, C., Van Bruggen, M.C., Van Der Pijl, J.W., Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis (2003) Arthritis Rheum., 48, pp. 1355-1362 | |
dc.description | Liang, M.H., Socher, S.A., Larson, M.G., Realiability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus (1989) Arthritis Rheum., 32, pp. 1107-1118 | |
dc.description | Symmons, D.P.M., Coopock, J.S., Bacon, P.A., Development and assessment of a computerized index of clinical disease activity in systemic lupus erythematosus (1988) Q J Med., 68, pp. 927-937 | |
dc.description | Bombardier, C., Gladman, D.D., Urowits, M.B., Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE (1992) Arthritis Rheum., 35, pp. 630-640 | |
dc.description | Guzman, J., Cardiel, M.H., Arce-Salinas, A., Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices (1992) J Rheumatol., 19, pp. 1551-1558 | |
dc.description | Petri, M., Buyon, J., Skovron, M.L., Reliability of SELENA-SLEDAI and flares as a clinical trial outcome measure (1998) Arthritis Rheum., 41, pp. S218 | |
dc.description | Liang, M.H., Socher, S.A., Roberts, W.N., Measurement of systemic lupus erythematosus activity in clinical research (1988) Arthritis Rheum., 31, pp. 817-825 | |
dc.description | Petri, M., Bochemstedt, L., Colman, J., Serial assessment of glomerular filtration rate in lupus nephropathy (1988) Kidney Int., 34, pp. 832-839 | |
dc.description | Gladman, D., Ginzler, E., Goldsmith, C., The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus (1996) Arthritis Rheum., 39, pp. 363-369 | |
dc.description | Gladman, D.D., Urowitz, M.B., Rahman, P., Ibanez, D., Tam, L.S., Accrual of organ damage over time in patients with systemic lupus erythematosus (2003) J Rheumatol., 30, pp. 1955-1959 | |
dc.description | Beyan, E., Beyan, C., Turan, M., Hematological presentation in systemic lupus erythematosus and its relationship with disease activity (2007) Hematology., 12, pp. 257-261 | |
dc.description | Hanly, J.G., Neuropsychiatry lupus (2005) Rheum Dis Clin North Am., 31, pp. 273-279 | |
dc.description | Nishihara, K.K., Furst, D.E., Aspirin and other nonsteroidal anti-inflammatory drugs (1997) Arthritis and allied conditions: a textbook of rheumatology, pp. 611-654. , In: Koopman WJ | |
dc.description | ed, Baltimore: Williams & Wilkins | |
dc.description | Wallace, D.J., Antimalarials-the 'real' advance in lupus (2001) Lupus., 10, pp. 385-387 | |
dc.description | Portnoy, J.Z., Callen, J.P., Ophthalmologic aspects of chloroquine and hydroxychloroquine therapy (1983) Int Dermatol., 22, pp. 273-278 | |
dc.description | Sapolsky, R.M., Romero, L.M., Munk, A.U., How do glucocorticoids influence stress responses? Integrating permissive | |
dc.description | suppressive | |
dc.description | stimulatory | |
dc.description | and preparative actions (2000) Endocr Rev., 21, pp. 55-89 | |
dc.description | O'Banion M.k, Winn, V.D., Young, D.A., cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase (1992) Proc Natl Acad Sci. USA, 89, pp. 4888-4892 | |
dc.description | Paliogianni, F., Ahuja, S.S., Yamada, H., Glucocorticoid inhibit T cell proliferation by downregulating proliferative signals mediated through both T cell antigen and interleukin-2 receptors (1992) Arthritis Rheum., 35, pp. S127 | |
dc.description | Lynch, J., McCune, W., Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders: state of the art (1997) Am J Respir Crit Care Med., 155, pp. 395-420 | |
dc.description | Gilchrist, D.M., Friedman, J.M., Teratogenesis and IV cyclophosphamide (letter) (1989) J Rheumatol., 16, pp. 1008-1009 | |
dc.description | Kirshon, B., Wasserstrum, N., Willis, R., Teratogenic effects of first trimester cyclophophamide therapy (1988) Obstet Gynecol., 72, p. 462 | |
dc.description | Sztenjnbok, M., Stewart, A., Diamond, H., Azathioprine in the treatment of systemic lupus erythematosus: a controlled study (1971) Arthritis Rheum., 14, pp. 639-645 | |
dc.description | McCune, W.J., Friedman, A.W., Immunosuppressive drug therapy for rheumatic disease (1993) Curr Opin Rheumatol., 5, pp. 282-292 | |
dc.description | DeMattos, A., Olvaei, A., Bennett, W., Nephrotoxicity of immunosuppressive: long-term consequences and challenges for the future (2000) Am J Kidney Dis., 35, pp. 333-346 | |
dc.description | Mello, S., Barros, D., Silva, A., Methotrexate as a preferential cyclooxygenase-2 inhibition in whole blood of patients with rheumatoid arthritis (2000) Rheumatology., 39, pp. 533-536. , (Oxf) | |
dc.description | Allison, A.C., Eugui, E.M., Mycophenolate mofetil and its mechanisms of action (2000) Immunopharmacology., 47, pp. 85-118 | |
dc.description | Bullingham, R.E., Nicholls, A.J., Kamm, B.R., Clinical pharmacokinetics of mycophenolate mofetil (1998) Clin Pharmacokinet., 34, pp. 429-455 | |
dc.description | Carr, S.F., Papp, E., Wu, J.C., Characterization of human type I and type II IMP dehydrogenases (1993) J Biol Chem., 268, pp. 27286-27290 | |
dc.description | Goldblum, R., Therapy of rheumatoid arthritis with mycophenolate mofetil (1993) Clin Exp Rheumatol., 11 (SUPPL. 8), pp. S117-S19 | |
dc.description | Anderson, K.C., Bates, M.P., Slaughenhoupt, B.L., Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation (1984) Blood., 63, pp. 1424-1433 | |
dc.description | Maloney, D.G., Liles, T.M., Czerwinski, D.K., Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma (1994) Blood., 84, pp. 2457-2466 | |
dc.description | Reff, M.E., Carner, K., Chambers, K.S., Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20 (1994) Blood., 83, pp. 435-445 | |
dc.description | Edwards, J.C., Szczepanski, L., Szechinski, J., Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis (2004) N Engl J Med., 350, pp. 2572-2581 | |
dc.description | Cohen, S.B., Emery, P., Greenwald, M.W., Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter | |
dc.description | randomized | |
dc.description | double-blind | |
dc.description | placebo-controlled | |
dc.description | phase III trial evaluating primary efficacy and safety at twenty-four weeks (2006) Arthritis Rheum., 54, pp. 2793-2806 | |
dc.description | Emery, P., Fleischmann, R., Filipowicz-Sosnowska, A., The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized | |
dc.description | double-blind | |
dc.description | placebocontrolled | |
dc.description | dose-ranging trial (2006) Arthritis Rheum., 54, pp. 1390-1400 | |
dc.description | Hauser, S.L., Waubant, E., Arnold, D.L., B-cell depletion with rituximab in relapsing-remitting multiple sclerosis (2008) N Engl J Med., 358, pp. 676-688 | |
dc.description | Pescovitz, M., Greenbaum, C., Krause-Steinrauf, H., Rituximab | |
dc.description | B-lymphocyte depletion | |
dc.description | and preservation of beta-cell function (2009) N Engl J Med., 261, pp. 2143-2152 | |
dc.description | Wallace, D.J., Stohl, W., Furie, R.A., A phase II | |
dc.description | randomized | |
dc.description | double-blind | |
dc.description | placebo-controlled | |
dc.description | dose-ranging study of belimumab in patients with active systemic lupus erythematosus (2009) Arthritis Rheum., 61, pp. 1168-1178 | |
dc.description | Petri, M., Hobbs, K., Gordon, C., Clinically meaningful improvements with epratuzumab (Anti-CD22 mAb targeting b-cells) in patients (Pts) with Moderate/Severe SLE flares: results from 2 randomized controlled trials (2008) Arthritis Rheum., 58, pp. S571 | |
dc.description | Urowitz, M.B., Gladman, D.D., Abu-Shakra, M., Farewell, V.T., Mortality studies in systemic lupus erythematosus. Results from a single center. III. Improved survival over 24 years (1997) J Rheumatol., 24, pp. 1061-1065 | |
dc.description | Merrell, M., Shulman, L.E., Determination of prognosis in chronic disease | |
dc.description | illustrated by systemic lupus erythematosus (1955) J Chronic Dis., 1, pp. 12-32 | |
dc.description | Bjornadal, L., Yin, L., Granath, F., Klareskog, L., Ekbom, A., Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964-95 (2004) J Rheumatol., 31, pp. 713-719 | |
dc.description | Wang, L.C., Yang, Y.H., Lu, M.Y., Chiang, B.L., Retrospective analysis of mortality and morbidity of pediatric systemic lupus erythematosus in the past two decades (2003) J Microbiol Immunol Infect., 36, pp. 203-208 | |
dc.description | Abu-Shakra, M., Gladman, D.D., Urowitz, M.B., Mortality studies in SLE: how far can we improve survival of patients with SLE (2004) Autoimmun Rev., 3, pp. 418-420 | |
dc.description | Moss, K.E., Ioannou, Y., Sultan, S.M., Haq, I., Isenberg, D.A., Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades (2002) Ann Rheum Dis., 61, pp. 409-413 | |
dc.description | Reveille, J.D., Bartolucci, A., Alarcón, G.S., Prognosis in systemic lupus erythematosus. Negative impact of increasing age at onset | |
dc.description | black race | |
dc.description | and thrombocytopenia | |
dc.description | as well as causes of death (1990) Arthritis Rheum., 33, pp. 37-48 | |
dc.description | Ward, M.M., Pyun, E., Studenski, S., Long-term survival in systemic lupus erythematosus. Patient characteristics associated with poorer outcomes (1995) Arthritis Rheum., 38, pp. 274-283 | |
dc.description | Ginzler, E.M., Diamond, H.S., Weiner, M., Schlesinger, M., Fries, J.F., Wasner, C., A multicenter study of outcome in systemic lupus erythematosus. I. Entry variables as predictors of prognosis (1982) Arthritis Rheum., 25, pp. 601-611 | |
dc.description | (2002), 51, pp. 371-374. , Trends in deaths from systemic lupus erythematosus-United States | |
dc.description | 1979-1998. MMWR Morb Mortal Wkly RepPistiner, M., Wallace, D.J., Nessim, S., Metzger, A.L., Klinenberg, J.R., Lupus erythematosus in the 1980s: a survey of 570 patients (1991) Semin Arthritis Rheum., 21, pp. 55-64 | |
dc.description | Naleway, A.L., Davis, M.E., Greenlee, R.T., Epidemiology of systemic lupus erythematosus in rural Wisconsin (2005) Lupus., 14, pp. 862-866 | |
dc.description | Nossent, J.C., Systemic lupus erythematosus on the Caribbean island of Curacao: an epidemiological investigation (1992) Ann Rheum Dis., 51, pp. 1197-1201 | |
dc.description | Vilar, M.J., Sato, E.I., Estimating the incidence of systemic lupus erythematosus in a tropical region (Natal | |
dc.description | Brazil) (2002) Lupus., 11, pp. 528-532 | |
dc.description | Stahl-Hallengren, C., Jonsen, A., Nived, O., Sturfelt, G., Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age | |
dc.description | decreasing frequency of renal manifestations and good prognosis (2000) J Rheumatol., 27, pp. 685-691 | |
dc.description | Jonsson, H., Nived, O., Sturfelt, G., Silman, A., Estimating the incidence of systemic lupus erythematosus in a defined population using multiple sources of retrieval (1990) Br J Rheumatol., 29, pp. 185-188 | |
dc.description | Voss, A., Green, A., Junker, P., Systemic lupus erythematosus in Denmark: clinical and epidemiological characterization of a county-based cohort (1998) Scand J Rheumatol., 27, pp. 98-105 | |
dc.description | Nossent, H.C., Systemic lupus erythematosus in the Arctic region of Norway (2001) J Rheumatol., 28, pp. 539-546 | |
dc.description | Hopkinson, N.D., Doherty, M., Powell, R.J., Clinical features and race-specific incidence/prevalence rates of systemic lupus erythematosus in a geographically complete cohort of patients (1994) Ann Rheum Dis., 53, pp. 675-680 | |
dc.description | Nightingale, A.L., Farmer, R.D., De Vries, C.S., Incidence of clinically diagnosed systemic lupus erythematosus 1992-1998 using the UK General Practice Research Database (2006) Pharmacoepidemiol Drug Saf., 15, pp. 656-661 | |
dc.description | Somers, E.C., Thomas, S.L., Smeeth, L., Schoonen, W.M., Hall, A.J., Incidence of systemic lupus erythematosus in the United Kingdom | |
dc.description | 1990-1999 (2007) Arthritis Rheum., 57, pp. 612-618 | |
dc.description | Gudmundsson, S., Steinsson, K., Systemic lupus erythematosus in Iceland 1975 through 1984. A nationwide epidemiological study in an unselected population (1990) J Rheumatol., 17, pp. 1162-1167 | |
dc.description | Lopez, P., Mozo, L., Gutierrez, C., Suarez, A., Epidemiology of systemic lupus erythematosus in a northern Spanish population: gender and age influence on immunological features (2003) Lupus., 12, pp. 860-865 | |
dc.description | Alamanos, Y., Voulgari, P.V., Siozos, C., Katsimpri, P., Tsintzos, S., Dimou, G., Epidemiology of systemic lupus erythematosus in northwest Greece. 1982-2001 (2003) J Rheumatol., 30, pp. 731-735 | |
dc.description | Anstey, N.M., Bastian, I., Dunckley, H., Currie, B.J., Systemic lupus erythematosus in Australian aborigines: high prevalence | |
dc.description | morbidity and mortality (1993) Aust NZ J Med., 23, pp. 646-651 | |
dc.description | Urowitz, M.B., Bookman, A.A.M., Koehler, B.E., The bimodal pattern of systemic lupus erythematosus (1976) Am J Med., 60, pp. 221-225 | |
dc.description | Abu-Shakra, M., Urowitz, M.B., Gladman, D.D., Mortality studies in systemic lupus erythematosus. Results from a single Centre I. Causes of death (1995) J Rheumatol., 22, pp. 1259-1264 | |
dc.description | Ward, M.M., Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus (1999) Arthritis Rheum., 42, pp. 338-346 | |
dc.language | en | |
dc.publisher | Nova Science Publishers, Inc. | |
dc.relation | Autoimmune Disorders: Symptoms, Diagnosis and Treatment | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Systemic Lupus Erythematosus: Definition, Pathogenesis And Treatment | |
dc.type | Capítulos de libros | |