Nitric Oxide And The Cardiovascular System: Cell Activation, Vascular Reactivity And Genetic Variant [Óxido Nítrico E Sistema Cardiovascular: Ativação Celular, Reatividade Vascular E Variante Genética]

dc.creatorDias R.G.
dc.creatorNegrao C.E.
dc.creatorKrieger M.H.
dc.date2011
dc.date2015-06-30T20:25:26Z
dc.date2015-11-26T14:49:17Z
dc.date2015-06-30T20:25:26Z
dc.date2015-11-26T14:49:17Z
dc.date.accessioned2018-03-28T22:00:16Z
dc.date.available2018-03-28T22:00:16Z
dc.identifier
dc.identifierArquivos Brasileiros De Cardiologia. , v. 96, n. 1, p. 68 - 75, 2011.
dc.identifier0066782X
dc.identifier10.1590/S0066-782X2011000100012
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79951602338&partnerID=40&md5=72e2b8d022a075e29728625b3f7cb93a
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107874
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107874
dc.identifier2-s2.0-79951602338
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253858
dc.descriptionNitric oxide (NO), primarily identified as an endotheliumderived relaxing factor, is a free radical that signals different biological processes. The identification of NO synthase (NOS) isoforms and the subsequent characterization of the mechanisms of cell activation of the enzymes permitted the partial understanding of both the physiological interactions and of the mechanisms of the diseases in which NO is involved. Mainly expressed in the vascular endothelium, the endothelial NOS isoform (eNOS) plays an important role in the regulation of vascular reactivity and in the development and progression of atherosclerosis. The purpose of this review is to contextualize the reader about the eNOS structure and its mechanisms of cell activation. In view of the advances in molecular biology, we will also address the known mechanisms of gene expression regulation and the role of variants on the genetic code of eNOS associated with cardiovascular phenotypes. Although the importance of NO as an atheroprotective molecule is recognized, our focus will be the review of the literature on NO and its participation in the modulation of the muscle vasodilatation phenotype.
dc.description96
dc.description1
dc.description68
dc.description75
dc.descriptionFurchgott, R.F., Zawadzki, J.V., The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine (1980) Nature, 288 (5789), pp. 373-376. , DOI 10.1038/288373a0
dc.descriptionIgnarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E., Chaudhuri, G., Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide (1987) Proc Natl Acad Sci USA, 84, pp. 9265-9269
dc.descriptionVila, E., Salaices, M., Cytokines and vascular reactivity in resistance arteries (2005) Am J Physiol Heart Circ Physiol, 288, pp. H1016-H1021
dc.descriptionMoncada, S., Palmer, R.M.J., Higgs, E.A., The biological significance of nitric oxide formation from L-arginine (1989) Biochemical Society Transactions, 17 (4), pp. 642-644
dc.descriptionKojda, G., Harrison, D., Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure (1999) Cardiovascular Research, 43 (3), pp. 562-571. , DOI 10.1016/S0008-6363(99)00169-8, PII S0008636399001698
dc.descriptionPalmer, R.M.J., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327 (6122), pp. 524-526. , DOI 10.1038/327524a0
dc.descriptionForstermann, U., Janus-faced role of endothelial NO synthase in vascular disease: Uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal (2006) Biological Chemistry, 387 (12), pp. 1521-1533. , DOI 10.1515/BC.2006.190, PII BCHM387121521
dc.descriptionLudmer, P.L., Selwyn, A.P., Shook, T.L., Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries (1986) New England Journal of Medicine, 315 (17), pp. 1046-1051
dc.descriptionVerma, S., Buchanan, M.R., Anderson, T.J., Endothelial Function Testing as a Biomarker of Vascular Disease (2003) Circulation, 108 (17), pp. 2054-2059. , DOI 10.1161/01.CIR.0000089191.72957.ED
dc.descriptionPepine, C.J., The impact of nitric oxide in cardiovascular medicine: Untapped potential utility (2009) Am J Med, 122 (5 SUPPL.), pp. S10-S15
dc.descriptionMadamanchi, N.R., Vendrov, A., Runge, M.S., Oxidative stress and vascular disease (2005) Arterioscler Thromb Vasc Biol, 25, pp. 29-38
dc.descriptionCai, H., NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease (2005) Circulation Research, 96 (8), pp. 818-822. , DOI 10.1161/01.RES.0000163631.07205.fb
dc.descriptionGao, L., Mann, G.E., Vascular NAD(P)H oxidase activation in diabetes: A doubleedged sword in redox signalling (2009) Cardiovasc Res, 82 (1), pp. 9-20
dc.descriptionDe Gennaro Colonna, V., Bianchi, M., Pascale, V., Ferrario, P., Morelli, F., Pascale, W., Asymmetric dimethylarginine (ADMA): An endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule (2009) Med Sci Monit, 15 (4), pp. RA91-RA101
dc.descriptionSessa, W.C., eNOS at a glance (2004) J Cell Sci, 117, pp. 2427-2429
dc.descriptionMarletta, M.A., Nitric oxide synthase: Aspects concerning structure and catalysis (1994) Cell, 78, pp. 927-930
dc.descriptionGovers, R., Rabelink, T.J., Cellular regulation of endothelial nitric oxide synthase (2001) Am J Physiol Renal Physiol, 280, pp. F193-F206
dc.descriptionStuehr, D.J., Structure-function aspects in the nitric oxide synthases (1997) Annual Review of Pharmacology and Toxicology, 37, pp. 339-359
dc.descriptionFerreiro, C.R., Chagas, A.C.P., Carvalho, M.H.C., Dantas, A.P., Scavone, C., Souza, L.C.B., Buffolo, E., Da, L.P.L., Expression of inducible nitric oxide synthase is increased in patients with heart failure due to ischemic disease (2004) Brazilian Journal of Medical and Biological Research, 37 (9), pp. 1313-1320
dc.descriptionAndrew, P.J., Mayer, B., Enzymatic function of nitric oxide synthases (1999) Cardiovascular Research, 43 (3), pp. 521-531. , DOI 10.1016/S0008-6363(99)00115-7, PII S0008636399001157
dc.descriptionAlderton, W.K., Cooper, C.E., Knowles, R.G., Nitric oxide synthases: Structure, function and inhibition (2001) Biochemical Journal, 357 (3), pp. 593-615. , DOI 10.1042/0264-6021:3570593
dc.descriptionShaul, P.W., Anderson, R.G., Role of plasmalemmal caveolae in signal transduction (1998) Am J Physiol, 275, pp. L843-L851
dc.descriptionWang, X.L., Sim, A.S., Wang, M.X., Murrell, G.A.C., Trudinger, B., Wang, J., Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity (2000) FEBS Letters, 471 (1), pp. 45-50. , DOI 10.1016/S0014-5793(00)01356-9, PII S0014579300013569
dc.descriptionGarcia-Cardena, G., Martasek, P., Masters, B.S.S., Skidd, P.M., Couet, J., Li, S., Lisanti, M.P., Sessa, W.C., Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo (1997) Journal of Biological Chemistry, 272 (41), pp. 25437-25440. , DOI 10.1074/jbc.272.41.25437
dc.descriptionRazani, B., Lisanti, M.P., Caveolin-deficient mice: Insights into caveolar function and human disease (2001) Journal of Clinical Investigation, 108 (11), pp. 1553-1561. , DOI 10.1172/JCI200114611
dc.descriptionBucci, M., Gratton, J.P., Rudic, R.D., Acevedo, L., Roviezzo, F., Cirino, G., In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation (2000) Nat Med, 6, pp. 1362-1367
dc.descriptionWang, X.L., Wang, J., Endothelial nitric oxide synthase gene sequence variations and vascular disease (2000) Mol Genet Metab, 70, pp. 241-251
dc.descriptionAlbrecht, E.W.J.A., Stegeman, C.A., Heeringa, P., Henning, R.H., Van, G.H., Protective role of endothelial nitric oxide synthase (2003) Journal of Pathology, 199 (1), pp. 8-17. , DOI 10.1002/path.1250
dc.descriptionGriffith, O.W., Stuehr, D.J., Nitric oxide synthases: Properties and catalytic mechanism (1995) Annu Rev Physiol, 57, pp. 707-736
dc.descriptionKorth, H.G., Sustmann, R., Thater, C., Butler, A.R., Ingold, K.U., On the mechanism of the nitric oxide synthase-catalyzed conversion of N omega-hydroxyl-Larginine to citrulline and nitric oxide (1994) J Biol Chem, 269, pp. 17776-17779
dc.descriptionHarrison, D.G., Cellular and molecular mechanisms of endothelial cell dysfunction (1997) Journal of Clinical Investigation, 100 (9), pp. 2153-2157
dc.descriptionVasquez-Vivar, J., Kalyanaraman, B., Martasek, P., Hogg, N., Masters, B.S.S., Karoui, H., Tordo, P., Pritchard Jr., K.A., Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors (1998) Proceedings of the National Academy of Sciences of the United States of America, 95 (16), pp. 9220-9225. , DOI 10.1073/pnas.95.16.9220
dc.descriptionCai, H., Harrison, D.G., Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress (2000) Circ Res, 87, pp. 840-844
dc.descriptionKlatt, P., Pfeiffer, S., List, B.M., Lehner, D., Glatter, O., Bachinger, H.P., Werner, E.R., Mayer, B., Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin (1996) Journal of Biological Chemistry, 271 (13), pp. 7336-7342. , DOI 10.1074/jbc.271.13.7336
dc.descriptionMayer, B., John, M., Heinzel, B., Werner, E.R., Wachter, H., Schultz, G., Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase (1991) FEBS Lett, 288, pp. 187-191
dc.descriptionBeckman, J.S., Koppenol, W.H., Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly (1996) Am J Physiol, 271, pp. C1424-C1437
dc.descriptionSearles, C.D., Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression (2006) Am J Physiol Cell Physiol, 291, pp. C803-C816
dc.descriptionMarsden, P.A., Heng, H.H.Q., Scherer, S.W., Stewart, R.J., Hall, A.V., Shi, X.M., Tsui, L.-C., Schappert, K.T., Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene (1993) Journal of Biological Chemistry, 268 (23), pp. 17478-17488
dc.descriptionKarantzoulis-Fegaras, F., Antoniou, H., Lai, S.-L.M., Kulkarni, G., D'Abreo, C., Wong, G.K.T., Miller, T.L., Marsden, P.A., Characterization of the human endothelial nitric-oxide synthase promoter (1999) Journal of Biological Chemistry, 274 (5), pp. 3076-3093. , DOI 10.1074/jbc.274.5.3076
dc.descriptionMalek, A.M., Jiang, L., Lee, I., Sessa, W.C., Izumo, S., Alper, S.L., Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase (1999) Biochemical and Biophysical Research Communications, 254 (1), pp. 231-242. , DOI 10.1006/bbrc.1998.9921
dc.descriptionSilacci, P., Formentin, K., Bouzourene, K., Daniel, F., Brunner, H.R., Hayoz, D., Unidirectional and oscillatory shear stress differentially modulate NOS III gene expression (2000) Nitric Oxide, 4, pp. 47-56
dc.descriptionDavis, M.E., Grumbach, I.M., Fukai, T., Cutchins, A., Harrison, D.G., Shear Stress Regulates Endothelial Nitric-oxide Synthase Promoter Activity through Nuclear Factor kappaB Binding (2004) Journal of Biological Chemistry, 279 (1), pp. 163-168. , DOI 10.1074/jbc.M307528200
dc.descriptionDavis, M.E., Cai, H., Drummond, G.R., Harrison, D.G., Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways (2001) Circulation Research, 89 (11), pp. 1073-1080
dc.descriptionMichel, T., Feron, O., Nitric oxide synthases: Which, where, how, and why? (1997) Journal of Clinical Investigation, 100 (9), pp. 2146-2152
dc.descriptionZhang, Q., Church, J.E., Jagnandan, D., Catravas, J.D., Sessa, W.C., Fulton, D., Functional relevance of Golgi- And plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells (2006) Arteriosclerosis, Thrombosis, and Vascular Biology, 26 (5), pp. 1015-1021. , DOI 10.1161/01.ATV.0000216044.49494.c4, PII 0004360520060500000012
dc.descriptionBoo, Y.C., Kim, H.J., Song, H., Fulton, D., Sessa, W., Jo, H., Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization (2006) Free Radical Biology and Medicine, 41 (1), pp. 144-153. , DOI 10.1016/j.freeradbiomed.2006.03.024, PII S0891584906002188
dc.descriptionFulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Regulation of endothelium-derived nitric oxide production by the protein kinase Akt (1999) Nature, 399, pp. 597-601
dc.descriptionDimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., Zeiher, A.M., Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation (1999) Nature, 399, pp. 601-605
dc.descriptionMount, P.F., Kemp, B.E., Power, D.A., Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation (2007) Journal of Molecular and Cellular Cardiology, 42 (2), pp. 271-279. , DOI 10.1016/j.yjmcc.2006.05.023, PII S0022282806005888
dc.descriptionKrieger, M.H., Di Lorenzo, A., Sessa, W., Telmisartan reverts endothelial dysfunction (2009) Am J Physiol Cell Physiol, , In press
dc.descriptionJoyner, M.J., Dietz, N.M., Nitric oxide and vasodilation in human limbs (1997) Journal of Applied Physiology, 83 (6), pp. 1785-1796
dc.descriptionAbrahams, V.C., Hilton, S.M., The role of active muscle vasodilatation in the alerting stage of the defence reaction (1964) J Physiol, 171, pp. 189-202
dc.descriptionBolme, P., Fuxe, K., Adrenergic and cholinergic nerve terminals in skeletal muscle vessels (1970) Acta Physiol Scand, 78, pp. 52-59
dc.descriptionMatsukawa, K., Shindo, T., Shirai, M., Ninomiya, I., Nitric oxide mediates cat hindlimb cholinergic vasodilation induced by stimulation of posterior hypothalamus (1993) Japanese Journal of Physiology, 43 (4), pp. 473-483. , DOI 10.2170/jjphysiol.43.473
dc.descriptionBlair, D.A., Glover, W.E., Greenfield, A.D., Roddie, I.C., Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress (1959) J Physiol, 148, pp. 633-647
dc.descriptionDietz, N.M., Rivera, J.M., Warner, D.O., Joyner, M.J., Is nitric oxide involved in cutaneous vasodilation during body heating in humans? (1994) J Appl Physiol, 76, pp. 2047-2053
dc.descriptionDietz, N.M., Engelke, K.A., Samuel, T.T., Fix, R.T., Joyner, M.J., Evidence for nitric oxide-mediated sympathetic forearm vasodilatation in humans (1997) Journal of Physiology, 498 (2), pp. 531-540
dc.descriptionMilner, P., Kirkpatrick, K.A., Ralevic, V., Toothill, V., Pearson, J., Burnstock, G., Endothelial cells cultured from human umbilical vein release ATP, substance P and acetylcholine in response to increased flow (1990) Proc Biol Sci, 241, pp. 245-248
dc.descriptionMajmudar, N.G., Anumba, D., Robson, S.C., Ford, G.A., Contribution of nitric oxide to beta 2-adrenoceptor mediated vasodilatation in human forearm arterial vasculature (1999) British Journal of Clinical Pharmacology, 47 (2), pp. 173-177. , DOI 10.1046/j.1365-2125.1999.00880.x
dc.descriptionPoirier, O., Mao, C., Mallet, C., Nicaud, V., Herrmann, S.M., Evans, A., Ruidavets, J.B., Cambien, F., Polymorphisms of the endothelial nitric oxide synthase gene - No consistent association with myocardial infarction in the ECTIM study (1999) European Journal of Clinical Investigation, 29 (4), pp. 284-290. , DOI 10.1046/j.1365-2362.1999.00451.x
dc.descriptionMiyahara, K., Kawamoto, T., Sase, K., Yui, Y., Toda, K., Yang, L.-X., Hattori, R., Shizuta, Y., Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene (1994) European Journal of Biochemistry, 223 (3), pp. 719-726. , DOI 10.1111/j.1432-1033.1994.tb19045.x
dc.descriptionPhilip, I., Plantefeve, G., Vuillaumier-Barrot, S., Vicaut, E., LeMarie, C., Henrion, D., Poirier, O., Benessiano, J., G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine (1999) Circulation, 99 (24), pp. 3096-3098
dc.descriptionHingorani, A.D., Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000 (2001) Atherosclerosis, 154, pp. 521-527
dc.descriptionTesauro, M., Thompson, W.C., Rogliani, P., Qi, L., Chaudhary, P.P., Moss, J., Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298 (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (6), pp. 2832-2835. , DOI 10.1073/pnas.97.6.2832
dc.descriptionFairchild, T.A., Fulton, D., Fontana, J.T., Gratton, J.P., McCabe, T.J., Sessa, W.C., Acidic hydrolysis as a mechanism for the cleavage of the Glu(298) - > Asp variant of human endothelial nitric-oxide synthase (2001) J Biol Chem, 276, pp. 26674-26679
dc.descriptionHingorani, A.D., Liang, C.F., Fatibene, J., Lyon, A., Monteith, S., Parsons, A., A common variant of the endothelial nitric oxide synthase (Glu298 - > Asp) is a major risk factor for coronary artery disease in the UK (1999) Circulation, 100, pp. 1515-1520
dc.descriptionHibi, K., Ishigami, T., Tamura, K., Mizushima, S., Nyui, N., Fujita, T., Ochiai, H., Umemura, S., Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction (1998) Hypertension, 32 (3), pp. 521-526
dc.descriptionShimasaki, Y., Yasue, H., Yoshimura, M., Nakayama, M., Kugiyama, K., Ogawa, H., Harada, E., Nakao, K., Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction (1998) Journal of the American College of Cardiology, 31 (7), pp. 1506-1510. , DOI 10.1016/S0735-1097(98)00167-3, PII S0735109798001673
dc.descriptionYoshimura, M., Yasue, H., Nakayama, M., Shimasaki, Y., Sumida, H., Sugiyama, S., Kugiyama, K., Nakao, K., A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese (1998) Human Genetics, 103 (1), pp. 65-69. , DOI 10.1007/s004390050785
dc.descriptionMiyamoto, Y., Saito, Y., Kajiyama, N., Yoshimura, M., Shimasaki, Y., Nakayama, M., Kamitani, S., Nakao, K., Endothelial nitric oxide synthase gene is positively associated with essential hypertension (1998) Hypertension, 32 (1), pp. 3-8
dc.descriptionLacolley, P., Gautier, S., Poirier, O., Pannier, B., Cambien, F., Benetos, A., Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects (1998) Journal of Hypertension, 16 (1), pp. 31-35. , DOI 10.1097/00004872-199816010-00006
dc.descriptionKato, N., Sugiyama, T., Morita, H., Nabika, T., Kurihara, H., Yamori, Y., Yazaki, Y., Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension (1999) Hypertension, 33 (4), pp. 933-936
dc.descriptionBenjafield, A.V., Morris, B.J., Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension (2000) Am J Hypertens, 13, pp. 994-998
dc.descriptionVallance, P., Collier, J., Moncada, S., Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man (1989) Lancet, 2, pp. 997-1000
dc.descriptionHaynes, W.G., Noon, J.P., Walker, B.R., Webb, D.J., Inhibition of nitric oxide synthesis increases blood pressure in healthy humans (1993) Journal of Hypertension, 11 (12), pp. 1375-1380
dc.descriptionFrandsen, U., Bangsbo, J., Sander, M., Huffner, L., Betak, A., Saltin, B., Hellsten, Y., Exercise-induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with N G-nitro-L- arginine methyl ester in humans (2001) Journal of Physiology, 531 (1), pp. 257-264. , DOI 10.1111/j.1469-7793.2001.0257j.x
dc.descriptionFabi, F., Argiolas, L., Chiavarelli, M., Del, B.P., Nitric oxide-dependent and -independent modulation of sympathetic vasoconstriction in the human saphenous vein (1996) European Journal of Pharmacology, 309 (1), pp. 41-50. , DOI 10.1016/0014-2999(96)00316-0
dc.descriptionDias, R.G., Alves, M.J., Pereira, A.C., Rondon, M.U., Dos Santos, M.R., Krieger, J.E., Glu298Asp eNOS gene polymorphism causes attenuation in non-exercising muscle vasodilatation (2009) Physiol Genomics, 37 (2), pp. 99-107
dc.languagept
dc.languagees
dc.languageen
dc.publisher
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsaberto
dc.sourceScopus
dc.titleNitric Oxide And The Cardiovascular System: Cell Activation, Vascular Reactivity And Genetic Variant [Óxido Nítrico E Sistema Cardiovascular: Ativação Celular, Reatividade Vascular E Variante Genética]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución