Sir2-related Protein 1 From Leishmania Amazonensis Is A Glycosylated Nad +-dependent Deacetylase

dc.creatorFessel M.R.
dc.creatorLira C.B.
dc.creatorGiorgio S.
dc.creatorRamos C.H.I.
dc.creatorCano M.I.N.
dc.date2011
dc.date2015-06-30T20:21:21Z
dc.date2015-11-26T14:48:27Z
dc.date2015-06-30T20:21:21Z
dc.date2015-11-26T14:48:27Z
dc.date.accessioned2018-03-28T21:59:14Z
dc.date.available2018-03-28T21:59:14Z
dc.identifier
dc.identifierParasitology. , v. 138, n. 10, p. 1245 - 1258, 2011.
dc.identifier311820
dc.identifier10.1017/S0031182011001077
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80053067069&partnerID=40&md5=2fee211a88b6d614ef66c0eaa420dc2b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107665
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107665
dc.identifier2-s2.0-80053067069
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253613
dc.descriptionSirtuin proteins form a family of NAD +-dependent protein deacetylases that are considered potential drug targets against parasites. Here, we present the first characterization of a sirtuin orthologue from Leishmania amazonensis, an aetiological agent of American tegumentary leishmaniasis that has been the subject of many studies focused in the development of therapeutic approaches. The protein has high sequence identity with other Kinetoplastid Silent information regulator 2 Related Protein 1 (Sir2RP1) and was named LaSir2RP1. The gene exists as a single copy, encoding a monomeric protein (LaSir2RP1) of approximately 41 kDa that has NAD +-dependent deacetylase activity. LaSir2RP1 was immunodetected in total protein extracts, in cytoplasmic granules, and in the secreted material of both promastigotes and lesion-derived amastigotes. Analysis of both lectin-affinity purified promastigote and amastigote extracts revealed the presence of a major enriched protein of approximately 66 kDa that was recognized by an anti-LaSir2RP1 serum, suggesting that a parasite sirtuin could be glycosylated in vivo. © 2011 Cambridge University Press.
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dc.languageen
dc.publisher
dc.relationParasitology
dc.rightsfechado
dc.sourceScopus
dc.titleSir2-related Protein 1 From Leishmania Amazonensis Is A Glycosylated Nad +-dependent Deacetylase
dc.typeArtículos de revistas


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