Multidrug-resistant Pseudomonas Aeruginosa: An Endemic Problem In Brazil [pseudomonas Aeruginosa Multirresistente: Um Problema Endêmico No Brasil]

dc.creatorNeves P.R.
dc.creatorMamizuka E.M.
dc.creatorLevy C.E.
dc.creatorLincopan N.
dc.date2011
dc.date2015-06-30T20:20:17Z
dc.date2015-11-26T14:48:16Z
dc.date2015-06-30T20:20:17Z
dc.date2015-11-26T14:48:16Z
dc.date.accessioned2018-03-28T21:58:59Z
dc.date.available2018-03-28T21:58:59Z
dc.identifier
dc.identifierJornal Brasileiro De Patologia E Medicina Laboratorial. , v. 47, n. 4, p. 409 - 420, 2011.
dc.identifier16762444
dc.identifier10.1590/S1676-24442011000400004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80053514124&partnerID=40&md5=63508312628d9a3d4cb1a3a6a771e1cc
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107603
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107603
dc.identifier2-s2.0-80053514124
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253554
dc.descriptionGlobal reports have documented the endemicity of multidrug-resistant (MDR) Pseudomonas aeruginosa associated with high levels of morbidity/mortality. In Brazil, outbreaks of MDR P. aeruginosa have been related to clonal dissemination. Currently, therapeutic options for the treatment of these infections are restricted to carbapenemic antibiotics (i.e., imipenem [IPM]). Thus, carbapenem resistance is a public health issue, since carbapenems are considered the last resort to nosocomial infections caused by MDR Gram-negative bacteria. In Brazil, the main mechanisms associated with MDR P. aeruginosa phenotypes are metallo-betalactamase (MBL) production (SPM-1 enzyme), presence of 16S rRNA methylase RmtD, loss of OprD porin, and overexpression of efflux pumps, which may explain the high level of carbapenem and aminoglycoside resistance. Accordingly, the emergence and dissemination of MDR strains is worrisome. Finally, based on national reports published by different groups of investigators, it is deduced that the convergence of multiple mechanisms of P. aeruginosa resistance has played a major role in the selection of endemic MDR clones widespread in Brazil.
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dc.languagept
dc.publisher
dc.relationJornal Brasileiro de Patologia e Medicina Laboratorial
dc.rightsaberto
dc.sourceScopus
dc.titleMultidrug-resistant Pseudomonas Aeruginosa: An Endemic Problem In Brazil [pseudomonas Aeruginosa Multirresistente: Um Problema Endêmico No Brasil]
dc.typeArtículos de revistas


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