Alcohol consumption compromises bone tissue, and thus may either impair or stop the fixation and maintenance of osseointegrated implants. To evaluate the effects of 5% and 15% ethanol on bone neoformation around porous hydroxiapatite implants. Fifteen rats were separated into 3 groups of 5 animals each: control (CT); 5% alcohol (A); and 15% alcohol (AA). After four weeks of ethanol consumption, the rats received porous hydroxiapatite implants into surgically made cavities in the femur. After surgery, the animals continued to consume ethanol until day 90 of the experiment, when they were euthanised and their femurs removed for histological processing. Bone tissue was found around the ceramic specimens of all the animals. The largest volume of neoformed bone around ceramic specimens occurred in the CT group, and the smallest in the AA group, followed by the A group. It was concluded that ethanol consumption produced a negative effect on osteogenesis around hydroxyapatite implants. Even small doses, such as the 5% ethanol dilution can interfere with bone repair.711115119Albrektsson, T., Branemark, P.I., Hansson, H.A., Lindstrom, I., Osseointegrated titanium implants (1981) Acta Orthopaedica Scandinavica, 52, pp. 155-170Andrade, J.C., Camilli, J.A., Kawachi, E.Y., Bertran, C.A., Behavior of dense and porous hydroxyapatite implants and tissue response in rat femoral defects (2002) Journal of Biomedical Materials Research, 62, pp. 30-36Baran, D.T., Steven, L.T., Teitelbaum, M.A.B., Paker, G., Cruvant, E.M., Avioli, L.V., Effects of alcohol ingestion on bone and mineral metabolism in rats (1980) American Journal of Physiology, 208, pp. E507-E510Buchaim, R.L., Roque, D.D., Roque, J.S., Toledo Filho, J.L., Andreo, J.C., Gen-Phos(R) implant in surgical cavities performed in the tibia of rats submitted to experimental chronic alcoholism: A microscopic study (2002) Revista da Faculdade de Odontologia de Bauru, 10 (1), pp. 17-22Camilli, J.A., Cunha, M.R., Bertran, C.A., Kawachi, E.Y., Subperiosteal hydroxyapatite implants in rats submitted to ethanol ingestion (2004) Archives of Oral Biology, 44, pp. 747-753Caria, P.H.F., Kawachi, E.Y., Bertran, C.A., Camilli, J.A., Biological assessment of porous-implant hydroxyapatite combined with periosteal grafting in maxillary defects (2007) Journal of Oral and Maxillofacial Surgery, 65, pp. 847-854Chakkalakal, D.A., Novak, J.R., Fritz, E.D., Mollner, T.J., McVicker, D.L., Lybarger, D.L., McGuire, M.H., Donohue, T.M., Chronic ethanol consumption results in deficient bone repair in rats (2002) Alcohol and Alcoholism, 37 (1), pp. 13-20Diez, A., Serrano, S., Cucurull, J., Marinoso, L.L., Bosh, J., Prug, J., Nogues, X., Aubia, J., Acute effects of ethanol on mineral metabolism and trabecular bone in Sprague-Dawley rats (1997) Calcified Tissues International, 61 (2), pp. 168-171Friday, K.E., Howard, G.A., Ethanol inhibits human bone cell proliferation and function in vitro (1991) Metabolism, 40 (6), pp. 562-565Holbrook, T.L., Connor, E.B., A prospective study of alcohol consumption and bone mineral density (1993) British Medical Journal, 306 (5), pp. 1506-1509Keiver, K., Duggal, S., Simpson, M.E., Ethanol administration results in a prolonged decrease in blood ionized calcium levels in the rat (2005) Alcohol, 37 (3), pp. 173-178Klein, R.F., Alcohol-induced bone disease: Impact of ethanol on osteoblast proliferation (1996) Alcoholism: Clinical and Experimental Research, 20 (3), pp. 572-578Klein, R.F., Fausti, K.A., Carlos, A.S., Ethanol inhibits human osteoblastic cell proliferation (1996) Alcoholism: Clinical and Experimental Research, 20 (3), pp. 572-578Kopelman, M.D., Thomson, A.D., Guerrini, I., Marshall, E.J., The Korsakoff Syndrome: Clinical aspects, psychology and treatment (2009) Alcohol and Alcoholism, 44 (2), pp. 148-154Legeros, R.Z., Properties of osteoconductive biomaterials: Calcium phosphates (2002) Clinical Orthopaedics and Related Research, 395, pp. 81-98Mandarin-de-Lacerda, C.A., What is the interest of normal and pathological morphological research to be quantitative? The exemple of the stereology (1999) Brazilian Journal Morphology, 16 (2), pp. 131-139Marks, S.C., Popoff, S.N., Bone cell biology: The regulation of development, structure, and function in the skeleton (1988) American Journal of Anatomy, 183 (1), pp. 2-44Nyquist, F., Halvosenv, V., Madsen, J.E., Nordsletten, L., Obrant, K.J., Ethanol and its effects on fracture healing and bone mass in male rats (1999) Acta Orthopaedica Scandinavica, 70 (2), pp. 212-216Nyquist, F., Düppe, H., Obrant, K.J., Bondeson, L., Nordsletten, L., Effects of alcohol on bone mineral and mechanical properties of bone in male rats (2002) Alcohol and Alcoholism, 37 (1), pp. 21-24Peng, T.C., Lian, J.B., Hirsch, P.F., Kusy, R.P., Lower serum osteocalcin in ethanol-fed rats (1991) Journal of Bone and Mineral Research, 6, pp. 107-115Sakakura, C.E., Marcantonio Jr., E., Rezende, M.L.R., O efeito do tabagismo na implantodontia (2001) BCI., Curitiba, 8 (32), pp. 276-280Sampson, H.W., Hebet, V.A., Bool, H.L., Champney, T.H., Effects alcohol consumption on adult and aged bone: Composition, morphology and hormone levels of a rat animal model (1998) Alcoholism: Clinical and Experimental Research, 22 (8), pp. 1746-1753Soares, E.A., Favaro, W.J., Cagnon, V.H.A., Bertran, C.A., Camilli, J.A., Effects of alcohol and nicotine on the mechanical resistance of bone and bone neoformation around hydroxyapatite implants (2010) Journal of Bone and Mineral Metabolism, 28 (1), pp. 101-107Svendsen, P., Hau, J., (1984) Handbook of laboratory animal science, , Boca RatonLondon: CRC PressVidigal Jr., G.M., Goisman, M., Osseointegração × biointegração: Uma análise crítica (2003) Revista Brasileira Odontologia, 4, pp. 54-56