Brazilian Experience Using High Dose Sequential Chemotherapy Followed By Autologous Hematopoietic Stem Cell Transplantation For Malignant Lymphomas

dc.creatorDuarte B.K.L.
dc.creatorMiranda E.C.
dc.creatorNucci M.
dc.creatorVigorito A.C.
dc.creatorPenteado F.J.
dc.creatorMarques Jr. J.F.C.
dc.creatorOliveira-Duarte G.B.
dc.creatorLorand-Metze I.G.H.
dc.creatorPagnano K.B.
dc.creatorDelamain M.T.
dc.creatorBaldissera R.
dc.creatorValente I.S.
dc.creatorde Souza C.A.
dc.date2011
dc.date2015-06-30T20:17:41Z
dc.date2015-11-26T14:47:50Z
dc.date2015-06-30T20:17:41Z
dc.date2015-11-26T14:47:50Z
dc.date.accessioned2018-03-28T21:58:28Z
dc.date.available2018-03-28T21:58:28Z
dc.identifier
dc.identifierRevista Brasileira De Hematologia E Hemoterapia. , v. 33, n. 6, p. 432 - 438, 2011.
dc.identifier15168484
dc.identifier10.5581/1516-8484.20110118
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84856487526&partnerID=40&md5=5dc141c60b034fa03041d9fbbf57c2fa
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107471
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107471
dc.identifier2-s2.0-84856487526
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253432
dc.descriptionObjective: To evaluate the use of high-dose sequential chemotherapy in a Brazilian population. Methods: High-dose cyclophosphamide followed by autologous hematopoietic stem cell transplantation is an effective and feasible therapy for refractory/relapsed lymphomas; this regimen has never before been evaluated in a Brazilian population. All patients (106 with high-grade non- Hodgkin lymphoma and 77 with Hodgkin's lymphoma) submitted to this treatment between 1998 and 2006 were analyzed. Chemotherapy consisted of the sequential administration of high-dose cyclophosphamide (4 or 7 g/m 2) and granulocyte-colony stimulating factor (300 μg/day), followed by peripheral blood progenitor cell harvesting, administration of etoposide (2g/m 2) and methotrexate (8 g/m 2 only for Hodgkin's lymphoma) and autologous hematopoietic stem cell transplantation. Results: At diagnosis, non-Hodgkin lymphoma patients had a median age of 45 (range: 8-65) years old, 78% had diffuse large B-cell lymphoma and 83% had stage III/IV disease. The Hodgkin's lymphoma patients had a median age of 23 (range: 7-68) years old, 64.9% had the nodular sclerosis subtype and 65% had stage III/IV disease. Nine Hodgkin's lymphoma patients (13%) and 10 (9%) non-Hodgkin lymphoma patients had some kind of cardiac toxicity. The overall survival, disease-free survival and progression-free survival in Hodgkin's lymphoma were 29%, 59% and 26%, respectively. In non-Hodgkin lymphoma, these values were 40%, 49% and 31%, respectively. High-dose cyclophosphamide-related mortality was 10% for Hodgkin's lymphoma and 5% for non-Hodgkin lymphoma patients. High-dose cyclophosphamide dosing had no impact on toxicity or survival for both groups. Conclusions: Despite a greater prevalence of poor prognostic factors, our results are comparable to the literature. The incidence of secondary neoplasias is noteworthy. Our study suggests that this approach is efficient and feasible, regardless of toxicity-related mortality.
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dc.description6
dc.description432
dc.description438
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dc.languageen
dc.publisher
dc.relationRevista Brasileira de Hematologia e Hemoterapia
dc.rightsaberto
dc.sourceScopus
dc.titleBrazilian Experience Using High Dose Sequential Chemotherapy Followed By Autologous Hematopoietic Stem Cell Transplantation For Malignant Lymphomas
dc.typeArtículos de revistas


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