Fk506 And Cyclosporin A Enhance The Survival Of Cultured And Grafted Rat Embryonic Dopamine Neurons

dc.creatorCastilho R.F.
dc.creatorHansson O.
dc.creatorBrundin P.
dc.date2000
dc.date2015-06-30T19:50:24Z
dc.date2015-11-26T14:47:08Z
dc.date2015-06-30T19:50:24Z
dc.date2015-11-26T14:47:08Z
dc.date.accessioned2018-03-28T21:57:19Z
dc.date.available2018-03-28T21:57:19Z
dc.identifier
dc.identifierExperimental Neurology. , v. 164, n. 1, p. 94 - 101, 2000.
dc.identifier144886
dc.identifier10.1006/exnr.2000.7405
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0033913626&partnerID=40&md5=4d6f3538d281fe3523c080a0356374a8
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/107210
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/107210
dc.identifier2-s2.0-0033913626
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1253141
dc.descriptionWe examined the effects of the immunophilin ligands and calcineurin inhibitors FK506 and cyclosporin A on the survival of rat embryonic dopamine (tyrosine hydroxylase (TH)-immunoreactive) neurons. The protective effects of FK506 and cyclosporin A were first studied in dissociated mesencephalic cell cultures subjected to serum deprivation. Significant increases in both the total number of surviving mesencephalic cells and the number of surviving TH- immunoreactive neurons were observed when FK506 or cyclosporin A was present following withdrawal of serum from the culture medium. In a second series of experiments, FK506 increased the survival of dopamine neurons when added only to a hibernation medium in which donor tissue pieces were stored for 7 days prior to preparation of the cultures. In a third set of experiments, we investigated the effects of FK506 and cyclosporin A on the survival of grafted rat embryonic dopamine neurons. When FK506 or cyclosporin A was present during tissue preparation and in the final mesencephalic cell suspension used for grafting, the survival of TH-immunoreactive neurons implanted in the striatum increased to around 185% of control values. In contrast, treatment of graft recipient rats, but not the graft suspension itself, with immunosuppressive doses of FK506 or cyclosporin A did not augment the survival of grafted TH-immunoreactive neurons. We conclude that administration of FK506 during storage of embryonic mesencephalic tissue and FK506 or cyclosporin A during preparation of nigral cell suspensions used for grafting can increase the survival of grafted embryonic dopamine neurons. (C) 2000 Academic Press.
dc.description164
dc.description1
dc.description94
dc.description101
dc.descriptionAnkarcrona, M., Dypbukt, J.M., Orrenius, S., Nicotera, P., Calcineurin and mitochondrial function in glutamate-induced neuronal cell death (1996) FEBS Lett., 394, pp. 321-324
dc.descriptionArmstrong, R.C., Aja, T.J., Hoang, K.D., Gaur, S., Bai, X., Alnemri, E.S., Litwack, G., Tomaselli, K.J., Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis (1997) J. Neurosci., 17, pp. 553-562
dc.descriptionBorlongan, C.V., Stahl, C.E., Fujisaki, T., Sanberg, P.R., Watanabe, S., Cyclosporine A-induced hyperactivity in rats: Is it mediated by immunosuppression, neurotrophism, or both? (1999) Cell Transplant., 8, pp. 153-159
dc.descriptionBrundin, P., Strecker, R.E., Preparation and intracerebral grafting of dissociated fetal brain tissue in rats (1991) Methods in Neurosciences, pp. 305-326. , P. M. Conn. San Diego: Academic Press
dc.descriptionBrundin, P., Karlsson, J., Emgard, M., Schierle, G.S.K., Hansson, O., Petersen, A., Castilho, R.F., Improving the survival of grafted dopaminergic neurons: A review over current approaches (2000) Cell Transplant., 9, pp. 179-195
dc.descriptionButcher, S.P., Henshall, D.C., Teramura, Y., Iwasaki, K., Sharkey, J., Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism (1997) J. Neurosci., 17, pp. 6939-6946
dc.descriptionCostantini, L.C., Chaturvedi, P., Armistead, D.M., McCaffrey, P.G., Deacon, T.W., Isacson, O., A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease (1998) Neurobiol. Dis., 5, pp. 97-106
dc.descriptionCrompton, M., The mitochondrial permeability transition pore and its role in cell death (1999) Biochem. J., 341, pp. 233-249
dc.descriptionDawson, T.M., Steiner, J.P., Dawson, V.L., Dinerman, J.L., Uhl, G.R., Snyder, S.H., Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 9808-9812
dc.descriptionDoucet, G., Brundin, P., Descarries, L., Bjorklund, A., Effect of prior dopamine denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts (1990) Eur. J. Neurosci., 2, pp. 279-290
dc.descriptionDuan, W.M., Widner, H., Brundin, P., Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats (1995) Exp. Brain Res., 104, pp. 227-242
dc.descriptionEmgard, M., Karlsson, J., Hansson, O., Brundin, P., Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts (1999) Exp. Neurol., 160, pp. 279-288
dc.descriptionFawcett, J.W., Barker, R.A., Dunnett, S.B., Dopaminergic neuronal survival and the effects of bFGF inexplant, three dimensional and monolayer cultures of embryonic rat ventral mesencephalon (1995) Exp. Brain Res., 106, pp. 275-282
dc.descriptionFriberg, H., Ferrand-Drake, M., Bengtsson, F., Halestrap, A.P., Wieloch, T., Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death (1998) J. Neurosci., 18, pp. 5151-5159
dc.descriptionGold, B.G., Katoh, K., Storm-Dickerson, T., The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve (1995) J. Neurosci., 15, pp. 7509-7516
dc.descriptionGrasbon-Frodl, E.M., Brundin, P., Mesencephalic neuron death induced by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E (1997) Exp. Brain Res., 113, pp. 138-143
dc.descriptionGrasbon-Frodl, E.M., Nakao, N., Brundin, P., The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation (1996) Brain Res. Bull., 39, pp. 341-347
dc.descriptionGriffiths, E.J., Halestrap, A.P., Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin (1991) Biochem. J., 274, pp. 611-614
dc.descriptionHansson, O., Castilho, R.F., Kaminski, G.S., Karlsson, J., Nicotera, P., Leist, M., Brundin, P., Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons (2000) Exp. Neurol., 164, pp. 102-111
dc.descriptionKaminski Schierle, G.S., Hansson, O., Brundin, P., Flunarizine improves the survival of grafted dopaminergic neurons (1999) Neuroscience, 94, pp. 17-20
dc.descriptionKarlsson, J., Emgard, M., Rosenblad, C., Brundin, P., Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons (1998) Brain Res., 805, pp. 155-168
dc.descriptionKitamura, Y., Itano, Y., Kubo, T., Nomura, Y., Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice (1994) J. Neuroimmunol., 50, pp. 221-224
dc.descriptionKroemer, G., Dallaporta, B., Resche-Rigon, M., The mitochondrial death/life regulator in apoptosis and necrosis (1998) Annu. Rev. Physiol., 60, pp. 619-642
dc.descriptionKuroda, S., Janelidze, S., Siesjo, B.K., The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats (1999) Brain Res., 835, pp. 148-153
dc.descriptionMahalik, T.J., Hahn, W.E., Clayton, G.H., Owens, G.P., Programmed cell death in developing grafts of fetal substantia nigra (1994) Exp. Neurol., 129, pp. 27-36
dc.descriptionMatsumoto, S., Friberg, H., Ferrand-Drake, M., Wieloch, T., Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion (1999) J. Cereb. Blood Flow Metab., 19, pp. 736-741
dc.descriptionMatsuura, K., Makino, H., Ogawa, N., Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine (1997) Exp. Neurol., 146, pp. 526-535
dc.descriptionMorioka, M., Hamada, J., Ushio, Y., Miyamoto, E., Potential role of calcineurin for brain ischemia and traumatic injury (1999) Prog. Neurobiol., 58, pp. 1-30
dc.descriptionNakao, N., Frodl, E.M., Duan, W.M., Widner, H., Brundin, P., Lazaroids improve the survival of grafted rat embryonic dopamine neurons (1994) Proc. Natl. Acad. Sci. USA, 91, pp. 12408-12412
dc.descriptionNikkhah, G., Olsson, M., Eberhard, J., Bentlage, C., Cunningham, M.G., Bjorklund, A., A microtransplantation approach for cell suspension grafting in the rat Parkinson model: A detailed account of the methodology (1994) Neuroscience, 63, pp. 57-72
dc.descriptionPincus, M.R., Abraham, N.Z., Toxicology and therapeutic drug monitoring (1996) Clinical Diagnosis and Management by Laboratory Methods, pp. 374-407. , J. B. Henry. Philadelphia: Saunders
dc.descriptionSauer, H., Brundin, P., Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts (1991) Rest. Neurol. Neurosci., 2, pp. 1783-1787
dc.descriptionSchierle, G.S., Hansson, O., Leist, M., Nicotera, P., Widner, H., Brundin, P., Caspase inhibition reduces apoptosis and increases survival of nigral transplants (1999) Nature Med., 5, pp. 97-100
dc.descriptionSchierle, G.S., Leist, M., Martinou, J.C., Widner, H., Nicotera, P., Brundin, P., Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants (1999) Eur. J. Neurosci., 11, pp. 3073-3081
dc.descriptionSnyder, S.H., Lai, M.M., Burnett, P.E., Immunophilins in the nervous system (1998) Neuron, 21, pp. 283-294
dc.descriptionSteiner, J.P., Connolly, M.A., Valentine, H.L., Hamilton, G.S., Dawson, T.M., Hester, L., Snyder, S.H., Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A (1997) Nature Med., 3, pp. 421-428
dc.descriptionTocci, M.J., Matkovich, D.A., Collier, K.A., Kwok, P., Dumont, F., Lin, S., Degudicibus, S., Hutchinson, N.I., The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes (1989) J. Immunol., 143, pp. 718-726
dc.descriptionUchino, H., Elmer, E., Uchino, K., Li, P.A., He, Q.P., Smith, M.L., Siesjo, B.K., Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat (1998) Brain Res., 812, pp. 216-226
dc.descriptionVan Muiswinkel, F.L., Drukarch, B., Steinbusch, H.W., De Vente, J., Sustained pharmacological inhibition of nitric oxide synthase does not affect the survival of intrastriatal rat fetal mesencephalic transplants (1998) Brain Res., 792, pp. 48-58
dc.descriptionVenkataramanan, R., Swaminathan, A., Prasad, T., Jain, A., Zuckerman, S., Warty, V., McMichael, J., Starzl, T., Clinical pharmacokinetics of tacrolimus (1995) Clin. Pharmacokinet., 29, pp. 404-430
dc.descriptionWang, H.G., Pathan, N., Ethell, I.M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Reed, J.C., Ca 2+-induced apoptosis through calcineurin dephosphorylation of BAD (1999) Science, 284, pp. 339-343
dc.descriptionWang, M.S., Zeleny-Pooley, M., Gold, B.G., Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve (1997) J. Pharmacol. Exp. Ther., 282, pp. 1084-1093
dc.descriptionWest, M.J., Slomianka, L., Gundersen, H.J., Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator (1991) Anat. Rec., 231, pp. 482-497
dc.descriptionYardin, C., Terro, F., Lesort, M., Esclaire, F., Hugon, J., FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures (1998) NeuroReport, 9, pp. 2077-2080
dc.descriptionZawada, W.M., Zastrow, D.J., Clarkson, E.D., Adams, F.S., Bell, K.P., Freed, C.R., Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats (1998) Brain Res., 786, pp. 96-103
dc.languageen
dc.publisher
dc.relationExperimental Neurology
dc.rightsfechado
dc.sourceScopus
dc.titleFk506 And Cyclosporin A Enhance The Survival Of Cultured And Grafted Rat Embryonic Dopamine Neurons
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución