Artículos de revistas
A Carbon-13 Nmr Study Of New 4-substituted Neostigmine Methyl Sulphates: Correlations Of Substituent-induced Chemical Shifts With Substituent Parameters
Registration in:
Canadian Journal Of Analytical Sciences And Spectroscopy. , v. 45, n. 3, p. X - 65, 2000.
12056685
2-s2.0-0034354714
Author
Rittner R.
Barbarini J.E.
Institutions
Abstract
The Carbon-13 NMR spectra of six new neostigimine derivatives, the 4-substituted-3-[{N,N-dimethylamino)carbonyl}oxy]-N′,N′,N′-tri methylbenzen-amminium methyl sulphates (4-substituted neostigmine methyl sulphates), and of the parent compound were recorded, and unequivocal chemical shift assignments through the use of HETCOR and COLOC sequences were performed. Large intramolecular interaction chemical shifts (ICS) were observed for carbon C-3 (-8.3 to +3.1 ppm), attachment site of the OC(O)N(CH3)2 group, and moderate ICS values (-3.3 to +3.5 ppm) for the remaining ring carbons, similarly to the values which were found for C-1 (-9.3 to +3.4 ppm) and for C-2 to C-6 (-3.0 to +3.8 ppm) of the corresponding 2-substituted-5-N′,N′-dimethylaminophenyl-N,N-dimethylcarbamates. Correlation analyses for the substituent-induced chemical shifts (SCS) with several sets of substituent parameters were carried out, through SSP, DSP and DSP-NLR treatments, as well as through multiple regression analysis. Good correlations were found for all ring carbons (r>0.97) and for the carbonyl carbon (r 0.9797). Resonance contribution is predominant for C-1 and C-2, while the electronegativity or inductive parameter is significant or the prevailing component for all ring carbons. Negative r values were found for several correlations (reverse substituent effect). 45 3 X 65 Stedman, E., (1929) Biochem, 23, p. 17 Aeschlimann, J.A., Reinert, M., (1931) J. Pharmacol.exp.ther., 43, p. 413 Millner O.E., Jr., Stanley, J.W., Purcell, W.P., (1974) J. Med. Chem., 17, p. 13 Hetnarski, B., O'Brien, R.D., (1975) J. Agric. Food Chem., 23, p. 709 Yamagami, C., Takao, N., Nishioka, T., Fujita, T., Takeuchi, Y., (1984) Org. Magn. Res., 22, p. 439 Yamagami, C., Sonoda, C., Takao, N., Tanaka, M., Yamada, J., Horisaka, K., Fujita, T., (1982) Chem. Pharm. Bull., 30, p. 4175 Perjessy, A., Jones, R.G., McClair, S.L., Wilkins, M., (1983) J. Org. Chem., 48, p. 1266 Rittner, R., Barbarini, J.E., Höehr, N.F., (2000), accepted by Pharmazie for publication in 06/09Höehr, N.F., (1993), Ph. D. Thesis, Universidade Estadual de Campinas(1985) Statgraphics, Statistical Graphics System, , STSC Inc., Utah Jackman, L.M., Sternhell, S., (1969) Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, 2nd Ed., , Pergamon Press, Oxford Rittner, R., Barbarini, J.E., Höehr, N.F., (1999) Can. J. Anal. Sci. Spectrosc., 44, p. 181 Breitmaier, E., Voelter, W., (1987) Carbon-13 NMR Spectroscopy, 3rd Ed., , VCH, Weinheim Rittner, R., Barbarini, J.E., (1998) Can. J. Anal. Sci. Spectrosc., 43, p. 14 Duddeck, H., (1987) Top. Stereochem., 16, p. 219 Yamagami, C., Sai, T., Takao, N., (1987) Aust. J. Chem., 40, p. 2005 Bromilow, J., Brownlee, R.T.C., Craik, D.J., Sadek, M., Taft, R.W., (1980) J. Org. Chem., 45, p. 2429 Exner, O., Dahn, H., Péchy, P., (1992) Magn. Reson. Chem., 30, p. 381 Exner, O., (1988) Correlation Analysis of Chemical Data, , Plenum, New York Bromilow, J., Brownlee, R.T.C., Craik, D.J., Fiske, P.R., Rowe, J.E., Sadek, M., (1981) J. Chem. Soc., Perkin Trans.2, p. 753 Canto, E.L., (1996), Ph. D. Thesis, Universidade Estadual de Campinas