dc.creatorRodrigues M.A.P.
dc.creatorDias L.
dc.creatorRenno A.L.
dc.creatorSousa N.C.
dc.creatorSmaal A.
dc.creatorSilva D.A.D.
dc.creatorHyslop S.
dc.date2014
dc.date2015-06-25T17:56:40Z
dc.date2015-11-26T14:46:22Z
dc.date2015-06-25T17:56:40Z
dc.date2015-11-26T14:46:22Z
dc.date.accessioned2018-03-28T21:56:03Z
dc.date.available2018-03-28T21:56:03Z
dc.identifier
dc.identifierToxicology. Elsevier Ireland Ltd, v. 323, n. , p. 109 - 124, 2014.
dc.identifier0300483X
dc.identifier10.1016/j.tox.2014.06.010
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903889240&partnerID=40&md5=4f3a684acc0ab1ea4bb1b760a6992783
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87088
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87088
dc.identifier2-s2.0-84903889240
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252816
dc.descriptionEnvenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) caused concentration-dependent muscle contracture that was not reversed by washing. Muscle damage was seen histologically and confirmed by quantification of creatine kinase-MB (CK-MB) release. Heating and preincubation of venom with p-bromophenacyl bromide (a phospholipase A2 inhibitor) abolished the venom-induced contracture and muscle damage. In contrast, indomethacin, a non-selective inhibitor of cyclooxygenase, and verapamil, a voltage-gated Ca2+ channel blocker, did not affect the responses to venom. Preincubation of venom with Bothrops or Bothrops/Crotalus antivenom or the addition of antivenom soon after venom attenuated the venom-induced changes in atrial function and tissue damage. These results indicate that B. jararacussu venom adversely affected rat atrial contractile activity and muscle organization through the action of venom PLA2; these venom-induced alterations were attenuated by antivenom. © 2014 Elsevier Ireland Ltd.
dc.description323
dc.description
dc.description109
dc.description124
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dc.languageen
dc.publisherElsevier Ireland Ltd
dc.relationToxicology
dc.rightsfechado
dc.sourceScopus
dc.titleRat Atrial Responses To Bothrops Jararacussu (jararacuçu) Snake Venom
dc.typeArtículos de revistas


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