Rat Atrial Responses To Bothrops Jararacussu (jararacuçu) Snake Venom

dc.creatorRodrigues M.A.P.
dc.creatorDias L.
dc.creatorRenno A.L.
dc.creatorSousa N.C.
dc.creatorSmaal A.
dc.creatorSilva D.A.D.
dc.creatorHyslop S.
dc.date2014
dc.date2015-06-25T17:56:40Z
dc.date2015-11-26T14:46:22Z
dc.date2015-06-25T17:56:40Z
dc.date2015-11-26T14:46:22Z
dc.date.accessioned2018-03-28T21:56:03Z
dc.date.available2018-03-28T21:56:03Z
dc.identifier
dc.identifierToxicology. Elsevier Ireland Ltd, v. 323, n. , p. 109 - 124, 2014.
dc.identifier0300483X
dc.identifier10.1016/j.tox.2014.06.010
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903889240&partnerID=40&md5=4f3a684acc0ab1ea4bb1b760a6992783
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/87088
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/87088
dc.identifier2-s2.0-84903889240
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252816
dc.descriptionEnvenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) caused concentration-dependent muscle contracture that was not reversed by washing. Muscle damage was seen histologically and confirmed by quantification of creatine kinase-MB (CK-MB) release. Heating and preincubation of venom with p-bromophenacyl bromide (a phospholipase A2 inhibitor) abolished the venom-induced contracture and muscle damage. In contrast, indomethacin, a non-selective inhibitor of cyclooxygenase, and verapamil, a voltage-gated Ca2+ channel blocker, did not affect the responses to venom. Preincubation of venom with Bothrops or Bothrops/Crotalus antivenom or the addition of antivenom soon after venom attenuated the venom-induced changes in atrial function and tissue damage. These results indicate that B. jararacussu venom adversely affected rat atrial contractile activity and muscle organization through the action of venom PLA2; these venom-induced alterations were attenuated by antivenom. © 2014 Elsevier Ireland Ltd.
dc.description323
dc.description
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dc.descriptionAbreu, V.A., Dal Belo, C.A., Hernandes-Oliveira, S.S., Borja-Oliveira, C.R., Hyslop, S., Furtado, M.F.D., Rodrigues-Simioni, L., Neuromuscular and phospholipase activities of venoms from three subspecies of Bothrops neuwiedi (B. n. goyazensis, B. n. paranaensis and B. n. diporus) (2007) Comp. Biochem. Physiol. A Mol. Integr. Physiol., 148, pp. 142-149
dc.descriptionAlloatti, G., Gattullo, G., Losano, G., Marsh, N.A., Pagliaro, P., Vono, P., The mechanical effects of rhinoceros horned viper (Bitis nasicornis) venom on the isolated perfused guinea-pig heart (1991) Exp. Physiol., 76, pp. 611-614
dc.descriptionAmaral, C.F.S., da Silva, O.A., Godoy, P., Miranda, D., Renal cortical necrosis following Bothrops jararaca and B. jararacussu snake bite (1985) Toxicon, 23, pp. 877-885
dc.descriptionAndrião-Escarso, S.H., Sampaio, S.V., Cunha, O.A., Marangoni, S., Oliveira, B., Giglio, J.R., Isolation and characterization of a new clotting factor from Bothrops jararacussu (jararacuçu) venom (1997) Toxicon, 35, pp. 1043-1052
dc.descriptionAndrião-Escarso, S.H., Soares, A.M., Rodrigues, V.M., Ângulo, Y., Díaz, C., Lomonte, B., Gutiérrez, J.M., Giglio, J.R., Myotoxic phospholipases A2 in Bothrops snake venoms: effects of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu (2000) Biochimie, 82, pp. 755-763
dc.descriptionAndrião-Escarso, S.H., Soares, A.M., Fontes, M.R., Fuly, A.L., Corrêa, F.M., Rosa, J.C., Greene, L.J., Giglio, J.R., Structural and functional characterization of an acidic platelet aggregation inhibitor and hypotensive phospholipase A2 from Bothrops jararacussu snake venom (2002) Biochem. Pharmacol., 64, pp. 723-732
dc.descriptionBarbosa, P.S., Martins, A.M., Havt, A., Toyama, D.O., Evangelista, J.S., Ferreira, D.P., Joazeiro, P.P., Monteiro, H.S., Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom (2005) Toxicon, 46, pp. 376-386
dc.descriptionBenvenuti, L.A., França, F.O.S., Bárbaro, K.C., Nunes, J.R., Cardoso, J.L.C., Pulmonary haemorrhage causing rapid death after Bothrops jararacussu snakebite: a case report (2003) Toxicon, 42, pp. 331-334
dc.descriptionBonfim, V.L., Toyama, M.H., Novello, J.C., Hyslop, S., Oliveira, C.R., Rodrigues-Simioni, L., Marangoni, S., Isolation and enzymatic characterization of a basic phospholipase A2 from Bothrops jararacussu snake venom (2001) J. Protein Chem., 20, pp. 239-245
dc.descriptionBortoleto, R.K., Murakami, M.T., Watanabe, L., Soares, A.M., Arni, R.K., Purification, characterization and crystallization of jararacussin-I, a fibrinogen-clotting enzyme isolated from the venom of Bothrops jararacussu (2002) Toxicon, 40, pp. 1307-1312
dc.descriptionBrazil, V., Do envenenamento ophidico e seu tratamento (1901) Coll. Trab. Inst. Butantan, pp. 31-55
dc.descriptionBrazil, V., Contribuição ao estudo do veneno ophidico. III. Tratamento das mordeduras de cobras (1903) Rev. Med. São Paulo, 6, pp. 265-278
dc.descriptionBrazil, V., (1911) A Defesa contra o Ophidismo, , Pocai & Weiss, São Paulo
dc.descriptionCalil-Elias, S., Thattasery, E., Martinez, A.M.B., Melo, P.A., Effect of perimuscular injection of Bothrops jararacussu venom on plasma creatine kinase levels in mice: influence of dose and volume (2002) Braz. J. Med. Biol. Res., 35, pp. 1233-1235
dc.descriptionCampbell, J.A., Lamar, W.W., (2004) Venomous Reptiles of the Western Hemisphere, 2. , Comstock Publishing Associates/Cornell University Press, Ithaca
dc.descriptionCardoso, D.F., Yamaguchi, I.K., Moura-da-Silva, A.M., Produção de soros antitoxinas e perspectivas de modernização por técnicas de biologia molecular (2009) Animais Peçonhentos no Brasil: Biologia, Clínica e Terapêutica dos Acidentes, pp. 419-431. , Sarvier/FAPESP, São Paulo, J.L.C. Cardoso, J.L.C. Cardoso, F.O.S. França, F.O.S. França, F.H. Wen, F.H. Wen, C.M.S. Málaque, C.M.S. Málaque, V. Haddad Jr, V. Haddad Jr (Eds.)
dc.descriptionCavalcante, W.L., Hernandez-Oliveira, S., Galbiatti, C., Randazzo-Moura, P., Rocha, T., Ponce-Soto, L., Marangoni, S., Rodrigues-Simioni, L., Biological characterization of Bothrops marajoensis snake venom (2011) J. Venom Res., 2, pp. 37-41
dc.descriptionda Silva, N.M.V., Arruda, E.Z., Murakami, Y.L.B., Moraes, R.A.M., El-Kik, C.Z., Tomaz, M.A., Fernandes, F.F.A., Melo, P.A., Evaluation of three Brazilian antivenom ability to antagonize myonecrosis and hemorrhage induced by Bothrops snake venoms in a mouse model (2007) Toxicon, 50, pp. 196-205
dc.descriptionDiaz-Oreiro, C., Gutiérrez, J.M., Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties (1997) Toxicon, 35, pp. 241-252
dc.descriptiondos Santos, M.C., Gonçalves, L.R.C., Fortes-Dias, C.L., Cury, Y., Gutiérrez, J.M., Furtado, M.F.D., A eficçcia do antiveneno botrépico-crotçlico na neutralizaáóo das principais atividades do veneno de Bothrops jararacussu (1992) Rev. Inst. Med. Trop. São Paulo, 34, pp. 77-83
dc.descriptionFatehi-Hassanabad, Z., Fatehi, M., Characterisation of some pharmacological effects of the venom of Vipera lebetina (2004) Toxicon, 43, pp. 385-391
dc.descriptionFerreira, L.A., Henriques, O.B., Lebrun, I., Batista, M.B., Prezoto, B.C., Andreoni, A.S., Zelnik, R., Habermehl, G., A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado) (1992) Toxicon, 30, pp. 33-40
dc.descriptionFletcher, J.E., Yang, C.C., Rosenberg, P., Basic phospholipase A2 from Naja nigricollis snake venom: phospholipid hydrolysis and effects on electrical and contractile activity of the rat heart (1982) Toxicol. Appl. Pharmacol., 66, pp. 39-54
dc.descriptionFrança, F.O.S., Málaque, C.M.S., Acidente botrópico (2009) Animais Peçonhentos no Brasil: Biologia, Clínica e Terapêutica dos Acidentes, pp. 81-95. , Sarvier/FAPESP, São Paulo, J.L.C. Cardoso, J.L.C. Cardoso, F.O.S. França, F.O.S. França, F.H. Wen, F.H. Wen, C.M.S. Málaque, C.M.S. Málaque, V. Haddad Jr, V. Haddad Jr (Eds.)
dc.descriptionFrança, F.O.S., Barbaro, K.C., Fan, H.W., Cardoso, J.L.C., Sano-Martins, I.S., Tomy, S.C., Lopes, M.H., Theakston, R.D.G., the Butantan Institute Antivenom Study Group Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital (2003) Trans. R. Soc. Trop. Med. Hyg., 97, pp. 312-317
dc.descriptionFurtado, M.F., Maruyama, M., Kamiguti, A.S., Antonio, L.C., Comparative study of nine Bothrops snake venoms from adult female snakes and their offspring (1991) Toxicon, 29, pp. 219-226
dc.descriptionGasparetti, A.L., Hyslop, S., Costa, S.K.P., Priviero, F.B.M., De Nucci, G., Antunes, E., Zanesco, A., Chronotropic response of β-adrenergic-, muscarinic-, and calcitonin gene-related peptide receptor agonists in right atria from neonatal capsaicin-treated rats (2002) Neurosci. Lett., 325, pp. 147-150
dc.descriptionGomes, A., De, P., Dasgupta, S.C., Occurrence of a unique protein toxin from the Indian king cobra (Ophiophagus hannah) venom (2001) Toxicon, 39, pp. 363-370
dc.descriptionGutiérrez, J.M., Lomonte, B., Efectos locales en el envenenamiento ofídico en América Latina (2009) Animais Peçonhentos no Brasil: Biologia, Clínica e Terapêutica dos Acidentes, pp. 352-365. , Sarvier/FAPESP, São Paulo, J.L.C. Cardoso, J.L.C. Cardoso, F.O.S. França, F.O.S. França, F.H. Wen, F.H. Wen, C.M.S. Málaque, C.M.S. Málaque, V. Haddad Jr, V. Haddad Jr (Eds.)
dc.descriptionGutiérrez, J.M., Núñez, J., Díaz, C., Cintra, A.C., Homsi-Brandeburgo, M.I., Giglio, J.R., Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu (1991) Exp. Mol. Pathol., 55, pp. 217-229
dc.descriptionGutiérrez, J.M., Ownby, C.L., Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity (2003) Toxicon, 42, pp. 915-931
dc.descriptionHarvey, A.L., Cardiotoxins from cobra venoms: possible mechanisms of action (1985) J. Toxicol.- Toxin Rev., 4, pp. 41-69
dc.descriptionHavt, A., Fonteles, M.C., Monteiro, H.A.S., The renal effects of Bothrops jararacussu venom and the role of PLA2 and PAF blockers (2001) Toxicon, 39, pp. 1841-1846
dc.descriptionHeluany, N.F., Homsi-Brandeburgo, M.I., Giglio, J.R., Prado-Franceschi, J., Rodrigues-Simioni, L., Effects induced by bothropstoxin, a component from Bothrops jararacussu snake venom, on mouse and chick muscle preparations (1992) Toxicon, 30, pp. 1203-1210
dc.descriptionHomsi-Brandeburgo, M.I., Queiroz, L.S., Santo-Neto, H., Rodrigues-Simioni, L., Giglio, J.R., Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin (1988) Toxicon, 26, pp. 615-627
dc.descriptionHuang, M.Z., Wang, Q.C., Liu, G.F., Effects of an acidic phospholipase A2 purified from Ophiophagus hannah (king cobra) venom on rat heart (1993) Toxicon, 31, pp. 627-635
dc.descriptionKashima, S., Roberto, P.G., Soares, A.M., Astolfi-Filho, S., Pereira, J.O., Giuliati, S., Faria, M., França, S.C., Analysis of Bothrops jararacussu venomous gland transcriptome focusing on structural and functional aspects: I-gene expression profile of highly expressed phospholipases A2 (2004) Biochimie, 86, pp. 211-219
dc.descriptionKetelhut, D.F., Mello, M.H., Veronese, E.L., Esmeraldino, L.E., Murakami, M.T., Arni, R.K., Giglio, J.R., Sampaio, S.V., Isolation, characterization and biological activity of acidic phospholipase A2 isoforms from Bothrops jararacussu snake venom (2003) Biochimie, 85, pp. 983-991
dc.descriptionMarchi-Salvador, D.P., Fernandes, C.A.H., Amui, S.F., Soares, A.M., Fontes, M.R.M., Crystallization and preliminary X-ray diffraction analysis of a myotoxic Lys49-PLA2 from Bothrops jararacussu venom complexed with p-bromophenacyl bromide (2006) Acta Cryst. F, 62, pp. 600-603
dc.descriptionMarcussi, S., Bernardes, C.P., Santos-Filho, N.A., Mazzi, M.V., Oliveira, C.Z., Izidoro, L.F., Fuly, A.L., Soares, A.M., Molecular and functional characterization of a new non-hemorrhagic metalloprotease from Bothrops jararacussu snake venom with antiplatelet activity (2007) Peptides, 28, pp. 2328-2339
dc.descriptionMartín, N., Bardisa, L., Pantoja, C., Barra, E., Demetrio, C., Valenzuela, J., Barrios, M., Cepúlveda, M.J., Involvement of calcium in the cardiac depressant actions of a garlic dialysate (1997) J. Ethnopharmacol., 55, pp. 113-118
dc.descriptionMazzi, M.V., Marcussi, S., Carlos, G.B., Stábeli, R.G., Franco, J.J., Ticli, F.K., Cintra, A.C., Sampaio, S.V., A new hemorrhagic metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization (2004) Toxicon, 44, pp. 215-223
dc.descriptionMelgarejo, A.R., Serpentes peçonhentas do Brasil (2009) Animais Peçonhentos no Brasil: Biologia, Clínica e Terapêutica dos Acidentes, pp. 42-70. , Sarvier/FAPESP, São Paulo, J.L.C. Cardoso, J.L.C. Cardoso, F.O.S. França, F.O.S. França, F.H. Wen, F.H. Wen, C.M.S. Málaque, C.M.S. Málaque, V. Haddad Jr, V. Haddad Jr (Eds.)
dc.descriptionMello, S.M., Linardi, A., Rennó, A.L., Tarsitano, C.A., Pereira, E.M., Hyslop, S., Renal kinetics of Bothrops alternatus (urutu) snake venom in rats (2010) Toxicon, 55, pp. 470-480
dc.descriptionMelo, P.A., Homsi-Brandeburgo, M.I., Giglio, J.R., Suarez-Kurtz, G., Antagonism of the myotoxic effects of Bothrops jararacussu venom and bothropstoxin by polyanions (1993) Toxicon, 31, pp. 285-291
dc.descriptionMelo, P.A., Suarez-Kurtz, G., Interaction of Bothrops venoms and antivenin on the release of creatine kinase from skeletal muscle (1987) Braz. J. Med. Biol. Res., 20, pp. 821-824
dc.descriptionMelo, P.A., Suarez-Kurtz, G., Release of creatine kinase from skeletal muscles by Bothrops venoms: heparin potentiation of inhibition by antivenin (1988) Braz. J. Med. Biol. Res., 21, pp. 545-548
dc.descriptionMelo, P.A., Suarez-Kurtz, G., Release of sarcoplasmic enzymes from skeletal muscle by Bothrops jararacussu venom: antagonism by heparin and by the serum of South American marsupials (1988) Toxicon, 26, pp. 87-95
dc.descriptionMilani, R., Jorge, M.T., Ferraz de Campos, F.P., Martins, F.P., Bousso, A., Cardoso, J.L.C., Ribeiro, L.A., Warrell, D.A., Snake bites by the jararacuçu (Bothrops jararacussu): clinicopathological studies of 29 proven cases in São Paulo State, Brazil (1997) Q. J. Med., 90, pp. 323-334
dc.descriptionMontecucco, C., Gutiérrez, J.M., Lomonte, B., Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action (2008) Cell Mol. Life Sci., 65, pp. 2897-2912
dc.descriptionMoraes, D.S., Abreu, V.A., Rostelato-Ferreira, S., Leite, G.B., Cruz-Höfling, M.A., Travaglia-Cardoso, S.R., Hyslop, S., Rodrigues-Simioni, L., Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations (2012) Toxicon, 59, pp. 294-299
dc.descriptionOliveira, M., Cavalcante, W.L.G., Arruda, E.Z., Melo, P.A., Silva, M.D.P., Gallacci, M., Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin (2003) Toxicon, 42, pp. 373-379
dc.descriptionOshima-Franco, Y., Hyslop, S., Cintra, A.C., Giglio, J.R., Cruz-Höfling, M.A., Rodrigues-Simioni, L., Neutralizing capacity of commercial bothropic antivenom against Bothrops jararacussu venom and bothropstoxin-I (2000) Muscle Nerve, 23, pp. 1832-1839
dc.descriptionOshima-Franco, Y., Leite, G.B., Silva, G.H., Cardoso, D.F., Hyslop, S., Giglio, J.R., Cruz-Höfling, M.A., Rodrigues-Simioni, L., Neutralization of the pharmacological effects of bothropstoxin-I from Bothrops jararacussu (jararacuçu) venom by crotoxin antiserum and heparin (2001) Toxicon, 39, pp. 1477-1485
dc.descriptionPérez, A.V., Saravia, P., Rucavado, A., Sant'Ana, C.D., Soares, A.M., Gutiérrez, J.M., Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu (2007) Toxicon, 49, pp. 1063-1069
dc.descriptionPetković, D., Pavlović, M., Matejević, D., Unković-Cvetković, N., Jovanović, T., Aleksić, N., Cvetković, M., Stamenović, B., Influence of calcium on the action of Vipera ammodytes ammodytes snake venom on the myocardium (1983) Toxicon, 21, pp. 887-892
dc.descriptionPinho, F.M., Burdmann, E.A., Fatal cerebral hemorrhage and acute renal failure after young Bothrops jararacussu snake bite (2001) Ren. Fail., 23, pp. 269-277
dc.descriptionPonce-Soto, L.A., Bonfim, V.L., Rodrigues-Simioni, L., Novello, J.C., Marangoni, S., Determination of primary structure of two isoforms 6-1 and 6-2 PLA2 D49 from Bothrops jararacussu snake venom and neurotoxic characterization using in vitro neuromuscular preparation (2006) Protein J., 25, pp. 147-155
dc.descriptionPrice, J.A., A colorimetric assay for measuring phospholipase A2 degradation of phosphatidylcholine at physiological pH (2007) J. Biochem. Biophys. Methods, 70, pp. 441-444
dc.descriptionQueiroz, L.S., Marques, M.J., Santo Neto, H., Acute local nerve lesions induced by Bothrops jararacussu snake venom (2002) Toxicon, 40, pp. 1483-1486
dc.descriptionQueiroz, L.S., Santo Neto, H., Rodrigues-Simioni, L., Prado-Franceschi, J., Muscle necrosis and regeneration after envenomation by Bothrops jararacussu snake venom (1984) Toxicon, 22, pp. 339-346
dc.descriptionRaina, R.K., Nǵanǵa, J.N., Telang, B.V., Neuromuscular, cardiac and smooth muscle effects of whole venom of Naja mossambica pallida (1978) Agressologie, 19, pp. 23-27
dc.descriptionRioli, V., Prezoto, B.C., Konno, K., Melo, R.L., Klitzke, C.F., Ferro, E.S., Ferreira-Lopes, M., Portaro, F.C., A novel bradykinin potentiating peptide isolated from Bothrops jararacussu venom using catalytically inactive oligopeptidase EP24. 15 (2008) FEBS J., 275, pp. 2442-2454
dc.descriptionRodrigues-Simioni, L., Borgese, N., Ceccarelli, B., The effects of Bothrops jararacussu venom and its components on frog nerve-muscle preparation (1983) Neuroscience, 10, pp. 475-489
dc.descriptionRodrigues-Simioni, L., Zamunér, S.R., Cogo, J.C., Borja-Oliveira, C.R., Prado-Franceschi, J., Cruz-Höfling, M.A., Corrado, A.P., Pharmacological evidence for a presynaptic action of venoms from Bothrops insularis (jararaca ilhoa) and Bothrops neuwiedi (jararaca pintada) (2004) Toxicon, 43, pp. 633-638
dc.descriptionRodrigues-Simioni, L., Floriano, R.S., Rostelato-Ferreira, S., Sousa, N.C., Marangoni, S., Ponce-Soto, L.A., Carregari, V.C., Hyslop, S., Presynaptic action of Bothriopsis bilineata smargadina (forest viper) venom in vitro (2011) Toxicon, 58, pp. 140-145
dc.descriptionRosenberg, P., The relationship between enzymatic activity and pharmacological properties of phospholipases in natural poisons (1986) Natural Toxins-Animal, Plant and Microbial, pp. 129-174. , Clarendon Press/Oxford University Press, Oxford, J.B. Harris, J.B. Harris (Eds.)
dc.descriptionSant'Ana, C.D., Bernardes, C.P., Izidoro, L.F., Mazzi, M.V., Soares, S.G., Fuly, A.L., Zingali, R.B., Soares, A.M., Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom (2008) Biochimie, 90, pp. 500-507
dc.descriptionSant'Ana, C.D., Ticli, F.K., Oliveira, L.L., Giglio, J.R., Rechia, C.G., Fuly, A.L., Selistre de Araújo, H.S., Sampaio, S.V., BjussuSP-I: a new thrombin-like enzyme isolated from Bothrops jararacussu snake venom (2008) Comp. Biochem. Physiol. A. Mol. Integr. Physiol., 151, pp. 443-454
dc.descriptionSanto Neto, H.S., Vomero, V.U., Marques, M.J., Insights into the loss of muscle mass following B. jararacussu venom in mice (2004) Toxicon, 44, pp. 847-850
dc.descriptionSantos, P.E.B., Souza, L., Freire-Maia, L., Almeida, P., Effects of crotoxin on the isolated guinea pig heart (1990) Toxicon, 28, pp. 215-224
dc.descriptionSifuentes, D.N., El-Kik, C.Z., Ricardo, H.D., Tomaz, M.A., Strauch, M.A., Calil-Elias, S., Arruda, E.Z., Melo, P.A., Ability of suramin to antagonize the cardiotoxic and some enzymatic activities of Bothrops jararacussu venom (2008) Toxicon, 51, pp. 28-36
dc.descriptionSilva-Junior, F.P., Guedes, H.L., Garvey, L.C., Aguiar, A.S., Bourguignon, S.C., Di Cera, E., Giovanni-de-Simone, S., BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: role of N-glycosylation in thermostability and active site accessibility (2007) Toxicon, 50, pp. 18-31
dc.descriptionSoares, A.M., Giglio, J.R., Chemical modifications on phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties (2003) Toxicon, 42, pp. 855-868
dc.descriptionSun, J.J., Walker, M.J.A., Actions of cardiotoxins from the southern Chinese cobra (Naja naja atra) on rat cardiac tissue (1986) Toxicon, 24, pp. 233-245
dc.descriptionWarrell, D.A., Snakebites in Central and South America: epidemiology, clinical features and clinical management (2004) Venomous Reptiles of the Western Hemisphere, 2, pp. 709-761. , Comstock Publishing Associates/Cornell University Press, Ithaca
dc.descriptionWermelinger, L.S., Dutra, D.L., Oliveira-Carvalho, A.L., Soares, M.R., Bloch, C., Zingali, R.B., Fast analysis of low molecular mass compounds present in snake venom: identification of ten new pyroglutamate-containing peptides (2005) Rapid Commun. Mass Spectrom., 19, pp. 1703-1708
dc.descriptionWolkowicz, P.E., Grenett, H.E., Huang, J., Wu, H.C., Ku, D.D., Urthaler, F., A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria (2007) Eur. J. Pharmacol., 576, pp. 122-131
dc.descriptionZaganelli, G.L., Zaganelli, M.G.M., Magalhães, A., Diniz, C.R., Lima, M.E., Purification and characterization of a fibrinogen-clotting enzyme from the venom of jararacuçu (Bothrops jararacussu) (1996) Toxicon, 34, pp. 807-819
dc.descriptionZamunér, S.R., Cruz-Höfling, M.A., Corrado, A.P., Hyslop, S., Rodrigues-Simioni, L., Comparison of the neurotoxic and myotoxic effects of Brazilian Bothrops venoms and their neutralization by commercial antivenom (2004) Toxicon, 44, pp. 259-271
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.relationToxicology
dc.rightsfechado
dc.sourceScopus
dc.titleRat Atrial Responses To Bothrops Jararacussu (jararacuçu) Snake Venom
dc.typeArtículos de revistas


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