The Diabetic Vasculature: Physiological Mechanisms Of Dysfunction And Influence Of Aerobic Exercise Training In Animal Models

Diabetes mellitus (DM) is associated with a number of complications of which chronic vascular complications are undoubtedly the most complex and significant consequence. With a significant impact on health care, 50-80% of people with diabetes die of cardiovascular disease (including coronary artery disease, stroke, peripheral vascular disease and other vascular disease), making it the major cause of morbidity and mortality in diabetic patients. A healthy lifestyle is essential in the management of DM, especially the inclusion of aerobic exercise, which has been shown effective in reducing the deleterious effects in vasculature. Interest in exercise studies has increased significantly with promising results that demonstrate a future for investigation. Considering the importance of this emerging field, the aim of this mini-review is to summarize and integrate animal studies investigating physiological mechanisms of vascular dysfunction and remodeling in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) and how these are influenced by chronic aerobic exercise training. © 2014 Elsevier Inc.

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Abebe, W., Macleod, K.M., Enhanced arterial contractility to noradrenaline in diabetic rats is associated with increased phosphoinositide metabolism (1991) Can J Physiol Pharmacol, 69, pp. 355-361

Abebe, W., Macleod, K.M., Influence of diabetes on noraepinephrine-induced inositol 1,4,5-trisphosphate levels in rat aorta (1991) Life Sci, 49, pp. 85-PL90

Agrawal, D.K., McNeill, J.H., Vascular responses to agonists in rat mesenteric artery from diabetic rats (1987) Can J Physiol Pharmacol, 65, pp. 1484-1490

Standards of medical care for patients with diabetes mellitus (1997) Diabetes Care, 20, pp. 3-S13. , American Diabetes Association

Diagnosis and classification of diabetes mellitus (2005) Diabetes Care, 28, pp. 37-S42. , American Diabetes Association

Arozal, W., Watanabe, K., Veeraveedu, P.T., Ma, M., Thandavarayan, R.A., Suzuki, K., Effects of angiotensin receptor bloker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats (2009) Biol Pharm Bull, 32, pp. 1411-1416

Avogaro, A., De Kreutzenberg, S.V., Fadini, G., Endothelial dysfunction: Causes and consequences in patients with diabetes mellitus (2008) Diabetes Res Clin Pract, 15, pp. 94-S101. , 10.1016/j.diabres.2008.09.021

Baluchnejadmojarad, T., Roghani, M., Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats: Mode of action (2008) Vascul Pharmacol, 49, pp. 1-5. , 10.1016/j.vph.2008.03.002

Bender, S.B., Klabunde, R.E., Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and α1-adrenoceptor-mediated vasoconstriction in type 2 diabetes (2007) Am J Physiol Heart Circ Physiol, 293, pp. 2281-H2288. , 10.1152/ajpheart.00566.2007

Bianchi, M.L.P., Antunes, L.M.G., Free radical and the main dietary antioxidants (1999) Rev Nutr, 12, pp. 123-130

Boor, P., Celec, P., Behuliak, M., Grancic, P., Kebis, A., Kukan, M., Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucher rats (2009) Metabolism, 58, pp. 1669-1677. , 10.1016/j.metabol.2009.05.025

Booth, F.W., Laye, M.J., Spangenburg, E., (2010) Gold Standards for Scientists Who Are Conducting Animal-based Exercise Studies, 108, pp. 219-221. , 10.1152/japplphysiol.00125.2009

Brondum, E., Kold-Petersen, H., Nilsson, H., Flycbjerg, A., Aalkjaer, C., Increased contractility to noradrenaline and normal endothelial function in mesenteric small arteries from the Goto-kakizaki rat model of type 2 diabetes (2008) J Physiol Sci, 58, pp. 333-339. , 10.2170/physiolsci.RP010108

Bruno, R.M., Ghiadoni, L., Vascular smooth muscle function: Defining the diabetic vascular phenotype (2013) Diabetologia, 56, pp. 2107-2109

Bucala, R., Tracey, K.J., Cerami, A., Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes (1991) J Clin Invest, 87, pp. 432-438

Bunker, A.K., Arce-Esquivel, A.A., Rector, R.S., Booth, F.W., Ibdah, J.A., Laughlin, M.H., Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat (2010) Am J Physiol Heart Circ Physiol, 298, pp. 889-H901. , 10.1152/ajpheart.01252.2009

Cade, W.T., Diabetes-related microvascular and macrovascular diseases in the physical therapy setting (2008) Phys Ther, 88 (11), pp. 1322-1335

Carr, C.L., Qi, Y., Davidson, B., Chadderdon, S., Jayaweera, A.R., Belcik, J.T., Dysregulated selectin expression and monocyte recruitment during ischemia-related vascular remodeling in diabetes mellitus (2011) Arterioscler Thromb Vasc Biol, 31, pp. 2526-2533. , 10.1161/ATVBAHA.111.230177

Caspersen, C.J., Powell, K.E., Christenson, G.M., Physical activity, exercise and physical fitness: Definitions and distinctions for health-related research (1985) Public Health Rep, 100, pp. 126-131

Celik, T., Iyisoy, A., Yuksel, U.C., Pediatric metabolic syndrome: A growing threat (2010) Int J Cardiol, 23, pp. 302-303. , 10.1016/j.ijcard.2008.11.143

Chakraphan, D., Sridulyakul, P., Thipakorn, B., Bunnag, S., Hyxley, V.H., Patumraj, S., Attenuation of endothelial dysfunction by exercise training in STZ-induced diabetic rats (2005) Clin Hemorheol Microcirc, 32, pp. 217-226

Chang, S.P., Chen, Y.H., Chang, W.C., Liu, I.M., Cheng, J.T., Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats (2006) Eur J Appl Physiol, 97, pp. 189-195

Chen, K.D., Li, Y.S., Kim, M., Li, S., Yuan, S., Chien, S., Mechanotransduction in response to shear stress. Roles of receptor tyrosine, kinases, integrins, and Shc (1999) J Biol Chem, 274, pp. 18393-18400

Chien, S., Li, S., Shyy, Y.J., Effects of mechanical forces on signal transduction and gene expression in endothelial cells (1998) Hypertension, 31, pp. 162-169

Chimen, M., Kennedy, A., Nirantharakumar, K., Pang, T.T., Andrews, P., Narendran, P., What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review (2012) Diabetologia, 55, pp. 542-551. , 10.1007/s00125-011-2403-2

Claudino, M.A., Delbin, M.A., Franco-Penteado, C.F., Priviero, F.B., De Nucci, G., Antunes, E., (2011) Life Sci, 88, pp. 272-277. , 10.1016/j.lfs.2010.11.018

Colberg, S.R., Sigal, R.J., Fernhall, B., Regensteiner, J.G., Blissmer, B.J., Rubin, R.R., Exercise and type 2 diabetes: The American College of Sports Medicine and American Diabetes Association: Joint position statement (2010) Diabetes Care, 33, pp. 147-e167. , 10.2337/dc10-9990

Nobrega, D., The subacute effects of exercise: Concept, characteristics, and clinical implications (2005) Exerc Sport Sci Rev, 33, pp. 84-87

Danaei, G., Finucane, M.M., Lu, Y., Singh, G.M., Cowan, M.J., Paciorek, C.J., National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants (2011) Lancet, 378, pp. 31-40

De Vriese, A.S., Verbeuren, T.J., Van D Voorde, J., Lameire, N.H., Vanhoutte, P.M., Endothelial dysfunction in diabetes (2000) Br J Pharmacol, 130, pp. 963-974

Delbin, M.A., Davel, A.P., Couto, G.K., De Araújo, G.G., Rossoni, L.V., Antunes, E., Interaction between advanced glycation end products formation and vascular responses in femoral and coronary arteries from exercise rats (2012) PLoS One, 7, p. 53318. , 10.1371/journal.pone.0053318

Dong, L., Zheng, Y.M., Van Riper, D., Rathore, R., Liu, Q.H., Singer, H.A., Functional and molecular evidence for impairment of calcium-activated potassium channels in type-1 diabetic cerebral artery smooth muscle cells (2008) J Cereb Blood Flow Metab, 28, pp. 377-386. , 10.1038/sj.jcbfm.9600536

Dyson, M.C., Alloosh, M., Vuhcetich, J.P., Mokelke, E.A., Sturek, M., Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet (2006) Comp Med, 56, pp. 35-45

Farmer, D.G., Kennedy, S., RAGE, vascular tone and vascular disease (2009) Pharmacol Ther, 124, pp. 185-194. , 10.1016/j.pharmthera.2009.06.013

Fisher, A.B., Chien, S., Barakat, A.I., Nerem, R.M., Endothelial cellular response to altered shear stress (2001) Am J Physiol Lung Cell Mol Physiol, 281, pp. 529-L533

Fiuza-Luces, C., Garatachea, N., Berger, N.A., Lucia, A., Exercise is the real polypill (2013) Physiology, 28, pp. 330-358. , 10.1152/physiol.00019.2013

Forbes, J.M., Cooper, M.E., Mechanisms of diabetic complications (2013) Physiol Rev, 93 (1), pp. 137-188. , 10.1152/physrev.00045.2011

Frey, R.S., Ushio-Fukai, M., Malik, A.B., PADPH oxidase-dependent signaling in endothelial cells: Role in physiology and pathophysiology (2009) Antioxid Redox Signal, 11, pp. 791-810. , 10.1089/ARS.2008.2220

Friebee, J.C., Stepp, D.W., Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats (2001) Am J Physiol, 281, pp. 1304-H1311

Garber, C.E., Blissmer, B., Deschenes, M.R., Franklin, B.A., Lamonte, M.J., Lee, I.M., American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise (2011) Med Sci Sports Exerc, 43, pp. 1334-1359

Goldin, A., Beckman, J.A., Schmidt, A.M., Creager, M.A., Advanced glycaton end products: Sparking the development of diabetic vascular injury (2006) Circulation, 114, pp. 597-605. , 10.1161/CIRCULATIONAHA.106.621854

Graier, W.F., Posch, K., Fleischhacker, E., Wascher, T.C., Kostner, G.M., Increased superoxide anion formation in endothelial cells during hyperglycemia: An adaptive response or initial step of vascular dysfunction? (1999) Diabetes Res Clin Pract, 45, pp. 153-160

Haskell, W., Lee, I.M., Pate, R., Powell, K.E., Blair, S.N., Franklin, B.A., Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and American heart association (2007) Med Sci Sports Exerc, 39, pp. 1423-1434

Hattori, Y., Kawasaki, H., Abe, K., Kanno, M., Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rats aorta (1991) Am J Physiol, 261, pp. 1086-H1094

Hayden, M.R., Sowers, J.R., Tyagi, S.C., The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: The matrix preloaded (2005) Cardiovasc Diabetol, 4, p. 9

Heidarianpour, A., Hajizadeh, S., Khoshbaten, A., Niaki, A.G., Biqdili, M.R., Pourkhalili, K., Effects of chronic exercise on endothelial dysfunction and insulin signaling of cutaneous microvascular in streptozotocin-induced diabetic rats (2007) Eur J Cardiovasc Prev Rehabil, 14, pp. 746-752

Kamata, K., Miyata, N., Kasuya, Y., Mechanisms of increased responses of the aorta to alpha-adrenoceptor agonists in streptozotocin-induced diabetic rats (1988) J Pharmacobiodyn, 11, pp. 707-713

Kamper, M., Tsimpoukidi, O., Chatzigeorgiou, A., Lymberi, M., Kamper, E.F., The antioxidant effect of angiotensin II receptor bloker, losartan in streptozotocin-induced diabetic rats (2010) Transl Res, 156, pp. 26-36. , 10.1016/j.trsl.2010.05.004

Katakam, P.V.G., Pollock, J.S., Pollock, D.M., Ujhelyi, M.R., Miller, A.W., Enchanced endothelin-1 response and receptor expression in small mesenteric arteries of insulin-resistant rats (2001) Am J Physiol Heart Circ Physiol, 208, pp. 522-H527

Katz, P.S., Trask, A.J., Souza-Smith, F.M., Hutchinson, K.R., Galantowicz, M.L., Lord, K.C., Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness (2011) Basic Res Cardiol, 106, pp. 1123-1134. , 10.1007/s00395-011-0201-0

Khazaei, M., Moien-Afshari, Kieffer, T.J., Laher, I., Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes (2008) Physiol Res, 57, pp. 847-856

Kojda, G., Hambrecht, R., Molecular mechanisms of vascular adaptations to exercise. Physical activity as an affective antioxidant therapy? (2005) Cardiovasc Res, 67, pp. 187-197

Korshunov, V.A., Schwartz, S.M., Berk, B.C., Vascular remodeling: Hemodynamic and biochemical mechanisms underlying Glagov's phenomenon (2007) Arterioscler Thromb Vasc Biol., 27, pp. 1722-1728

Kwon, M.J., Kim, B., Lee, Y.S., Kim, T.Y., Role of superoxide dismutase 3 in skin inflammation (2012) J Dermatol Sci, 67, pp. 81-87. , 10.1016/j.jdermsci.2012.06.003

Langenstroer, P., Pieper, G.M., Regulation of spontaneous EDRF releases in diabetic rat aorta by oxygen free radical (1992) Am J Physiol, 263, pp. 257-H265

Lee, S., Park, Y., Dellsperger, K.C., Zhang, C., Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice (2011) Am J Physiol Heart Circ Physiol, 301, pp. 306-H314

Leo, C.H., Joshi, A., Woodman, O.L., Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery (2010) Am J Physiol Heart Circ Physiol, 299, pp. 502-H511. , 10.1152/ajpheart.01197.2009

Lu, T., Zhang, D.M., Wang, X.L., He, T., Wang, R.X., Chai, Q., Regulation of coronary arterial BK channels by caveolae-mediated angiotensin II signaling in diabetes mellitus (2010) Circ Res, 106, pp. 1164-1173. , 10.1161/CIRCRESAHA.109.209767

Madden, K.M., Lockhart, C., Cuff, D., Potter, T.F., Meneilly, G.S., Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia (2009) Diabetes Care, 32, pp. 1531-1535. , 10.2337/dc09-0149

Malakul, W., Thirawarapan, S., Suvitayavat, W., Woodman, O.L., Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta (2008) Clin Exp Pharmacol Physiol, 35, pp. 192-200. , 10.1111/j.1440-1681.2007.04811.x

Maron, B.A., Michel, T., Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase (2012) Circ J, 76, pp. 2497-2512

Martin, J.S., Padilla, J., Jenkins, N.T., Crissey, J.M., Bender, S.B., Rector, R.S., Functional adpatations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat (2012) J Appl Physiol, 113, pp. 1223-1232. , 10.1152/japplphysiol.00823.2012

Mattace-Raso, F.U., Van Der Cammen, T.J., Hofman, A., Van Popele, N.M., Bos, M.L., Schalekamp, M.A., Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study (2006) Circulation, 113, pp. 657-663

Mayhan, W.G., Sun, H., Mayhan, J.F., Patel, K.P., Influence of exercise on dilatation of the basilar during diabetes mellitus (2004) J Appl Physiol, 96, pp. 1730-1737

Mayhan, W.G., Arrick, D.M., Patel, K.P., Sun, H., Exercise training normalizes impaired NOS-dependent response of cerebral arterioles in type 1 diabetic rats (2011) Am J Physiol Heart Circ Physiol, 300, pp. 1013-H1020. , 10.1152/ajpheart.00873.2010

McLeod, K.M., McNeil, J.H., The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels (1985) Can J Physiol Pharmacol, 63, pp. 52-57

McNeilly, A.M., McClean, C., Murphy, M., McEneny, J., Trinick, T., Burke, G., Exercise training and impaired glucose tolerance in obese humans (2012) J Sports Sci, 30, pp. 725-732. , 10.1080/02640414.2012.671952

Mezzetti, A., Cipollone, F., Cuccurullo, F., Oxidative stress and cardiovascular complications in diabetes: Isoprostanes as new markers on an old paradigm (2000) Cardiovasc Res, 18, pp. 475-488

Minami, A., Isshimura, N., Harada, N., Sakamoto, S., Niwa, Y., Nakaya, Y., Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, otsuka long-evans tokushima fatty rats (2002) Atherosclerosis, 162, pp. 85-92

Moien-Afshari, F., Ghosh, S., Elmi, S., Khazaei, M., Rahman, M.M., Sallam, N., Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice (2008) Am J Physiol Heart Circ Physiol, 295, pp. 1470-H1480

Moien-Afshari, F., Ghosh, S., Elmi, S., Rahman, M.M., Sallam, N., Khazaei, M., Exercise restores endothelial function independently of weight loos or hyperglycaemic status in dbd/db mice (2008) Diabetologia, 51, pp. 1327-1337. , 10.1007/s00125-008-0996-x

Mokelke, E.A., Hu, Q., Song, M., Toro, L., Reddy, H.K., Sturek, M., Altered functional coupling of coronary K + channels in diabetic dyslipidemic pigs is prevented by exercise (2003) J Appl Physiol, 95, pp. 1179-1193

Mokelke, E.A., Dietz, N.J., Eckman, D.M., Nelson, M.T., Sturek, M., Diabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K + current (2005) Am J Physiol Heart Circ Physiol, 288, pp. 1233-H1241

Molnár, D., The prevalence of the metabolic syndrome and type 2 diabetes mellitus in children and adolescents (2004) Int J Obes Relat Metab Disord, 28, pp. 70-S74

Mulvany, M.J., Baumbach, G.L., Aalkjaer, C., Heagerty, A.M., Korsgaard, N., Schiffrin, E.L., Vascular remodeling (1996) Hypertension, 28, pp. 505-506

Murad, F., Nitric oxide and cyclic guanosine monophosphate signaling in the eye (2008) Can J Ophthalmol, 43, pp. 291-294. , 10.3129/i08-044

Napoli, C., Ignarro, L.J., Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases (2009) Arch Pharm Res, 32, pp. 1103-1108. , 10.1007/s12272-009-1801-1

Nelson, M.E., Rejeski, W.J., Blair, S.N., Duncan, P.W., Judge, J.O., King, A.C., Physical activity and public health in older adults: Recommendation from the American College of Sports Medicine and American Heart Association (2007) Med Sci Sports Exerc, 39, pp. 1435-1445

Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., Walsh, K., Obesity, adiponectin and vascular inflammatory disease (2003) Curr Opin Lipidol, 14, pp. 561-566

Palmer, A.M., Thomas, C.R., Gopaul, N., Dhir, S., Anggard, E.E., Poston, L., Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat (1998) Diabetologia, 41, pp. 148-156

Pannirselvam, M., Simon, V., Verma, S., Anderson, T., Triggle, C.R., Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice (2003) Br J Pharmacol, 140, pp. 701-706

Park, Y., Yang, J., Zhang, H., Chen, X., Zhang, C., Effect of PAR2 in regulation TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice (2011) Basic Res Cardiol, 106, pp. 111-123. , 10.1007/s00395-010-0129-9

Phillips, J.K., Vance, A.M., Raj, R.S., Mandala, M., Linder, E.A., Gokina, N.I., Impact of experimental diabetes on the maternal uterine vascular remodeling during rat pregnancy (2012) Reprod Sci, 19, pp. 322-331. , 10.1177/1933719111424435

Pieper, G.M., Langenstroer, P., Siebeneich, W., Diabetic-indiced endothelial dysfunction in rat aorta: Role of hydroxyl radicals (1997) Cardiovasc Res, 34, pp. 145-156. , 10.1016/S0008-6363(96)00237-4

Rees, D.A., Alcolado, J.C., Animal models of diabetes (2005) Diabet Med, 22, pp. 359-370

Rojas, A., Romay, S., Gonzalez, D., Herrera, B., Delgado, R., Otero, K., Regulation of endothelial nitric oxide synthase expression by albumin-derived advanced glycosylation end products (2000) Circ Res, 86, pp. 50-E54. , 10.1161/01.RES.86.3.e50

Rupérez, F.J., García-Martínez, D., Baena, B., Maeso, N., Cifuentes, A., Barbas, C., Evolution of oxidative stress parameters and response to oral vitamins e and C in streptozotocin-induced diabetic rats (2008) J Pharm Pharmacol, 60, pp. 871-878. , 10.1211/jpp.60.7.0008

Russo, I., Del Mese, P., Doronzo, G., Matiello, L., Viretto, M., Bosia, A., Resistance to the nitric oxide/cyclic guanosine 5′-monophosphate/ protein kinase G pathway in vascular smooth muscle cells from the obsese Zucker rats, a classical animal model of insulin resistance: Role of oxidative stress (2008) Endocrinology, 149, pp. 1480-1489

Sakamoto, S., Minami, K., Niwa, Y., Ohnaka, M., Nakaya, Y., Mizuno, A., Effect of exercise training and food restriction on endothelium-dependent relaxation in the otsuda long-evans tokushima fatty rat, model of spontaneous NIDDM (1998) Diabetes, 47, pp. 82-86

Sandu, O., Song, K., Cai, W., Zheng, F., Uribarri, J., Vlassara, H., Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake (2005) Diabetes, 54, pp. 2314-2319

Sasaki, N., Yamashita, T., Takaya, T., Shinohara, M., Shiraki, R., Takeda, M., Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus (2008) Arterioscler Thromb Vasc Biol, 28, pp. 1068-1076. , 10.1161/ATVBAHA.107.160754

Schalkwijk, C.G., Stehouwer, C.D., Vascular complications in diabetes mellitus. The role of endothelial dysfunction (2005) Clin Sci, 109, pp. 143-159

Schmidt, A.M., Stern, D.M., RAGE: A new target for the prevention and treatment of the vascular and inflammatory complications of diabetes (2000) Trends Endocrinol Metab, 11, pp. 368-375

Shi, Y., Vanhoutte, P.M., Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats (2008) Br J Pharmacol, 154, pp. 639-651. , 10.1038/bjp.2008.110

Shyy, J.Y., Chien, S., Role of integrins in endothelial mechanosensing of shear stress (2002) Circ Res, 91, pp. 769-775

Souza-Smith, F.M., Katz, P.S., Trask, A.J., Stewart, Jr.J.A., Lord, K.C., Varner, K.J., Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling (2011) PLoS One, 6, p. 23337. , 10.1371/journal.pone.0023337

Spinetti, G., Kraenkel, N., Emanueli, C., Madeddu, P., Diabetes and vessel wall remodelling: From mechanistic insights to regenative therapies (2008) Cardiovasc Res, 78, pp. 265-273. , 10.1093/cvr/cvn039

Srinivasan, S., Hatley, M.E., Bolick, D.T., Palmer, L.A., Edelstein, D., Brownlee, M., Hyperglycaemia-induced superoxide production descreases eNOS expression via AP-1 activation in aortic endothelial cells (2004) Diabetologia, 47, pp. 1727-1734

Stoppa, G.R., Cesquini, M., Roman, E.A., Ogo, S.H., Torsoni, M.A., Aminoguanidine prevented impairment of blood antioxidant system in isnulin-dependent diabetic rats (2006) Life Sci, 78, pp. 1352-1361

Su, J., Lucchesi, P.A., Gonzalez-Villalobos, R.A., Palen, D.I., Rezk, B.M., Suzuki, Y., Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice (2008) Arterioscler Thromb Vasc Biol, 28, pp. 1432-1438. , 10.1161/ATVBAHA.108.167205

Surwit, R.S., Kuhn, C.M., Cochrane, C., McCubbin, J.A., McCubbin, J.A., Feinglos, M.N., Diet-induced type II diabetes in C57BL/6J (1988) Diabetes, 37, pp. 1163-1167

Taylor, P.D., Oon, B.B., Thomas, C.R., Poston, L., Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetic rats (1994) Br J Pharmacol, 111, pp. 35-41

Trask, A.J., Delbin, M.A., Katz, P.S., Zanesco, A., Lucchesi, P.A., Differential coronary resistance microvessel remodeling between type 1 and type 2 diabetic mice: Impact of exercise training (2012) Vasc Pharmacol, 57, pp. 187-193

Trask, A.J., Katz, P.S., Kelly, A.P., Galantowicz, M.L., Cismowski, M.J., West, T.A., Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome (2012) J Appl Physiol, 113, pp. 1128-1140. , 10.1152/japplphysiol.00604.2012

Vanhoutte, P.M., Mombouli, J.V., Vascular endothelium: Vasoactive mediators (1996) Prog Cardiovasc Dis, 39, pp. 229-238

Wang, R.X., Shi, H.F., Chai, Q., Wu, Y., Sun, W., Ji, Y., Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2 +-activated K+ channel impairment (2012) Chin Med J, 125, pp. 2548-2555

Wautier, M.P., Chappey, O., Corda, S., Stern, D.M., Schmidt, A.M., Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE (2001) Am J Physiol Endocrinol Metab, 280, pp. 685-E694

Witczak, C.A., Sturek, M., Exercise prevents diabetes-induced impairment in superficial buffer barrier in porcine coronary smooth muscle (2004) J Appl Physiol, 96, pp. 1069-1079

Health Organization, W., (2004) Diabetes Action Now: An Initiative of World Health Organization and the International Diabetes Federation. Switzerland

Health Organization, W., (2009) Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks. Switzerland

Health Organization, W., (2010) Global Recommendations on Physical Activity for Health. Switzerland

Wu, S.Q., Hopfner, R.L., McNeill, J.R., Wilson, T.W., Gopalakrishnan, V., Altered paracrine effect of endothelin in blood vessels of the hyperinsulinemic, insulin resistant obese Zucker rat (2000) Cardiovasc Res, 45, pp. 994-1000

Xiang, L., Naik, J.S., Abram, S.R., Hester, R.L., Chronic hyperglycemia impairs functional vasodilation via increasing thromboxane-receptor-mediated vasoconstriction (2007) Am J Physiol Heart Circ Physiol, 292, pp. 231-H236. , 10.1152/ajpheart.00623.2006

Xu, A., Vanhoutte, P.M., Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease (2012) Am J Physiol Heart Circ Physiol, 302, pp. 1231-H1240. , 10.1152/ajpheart.00765.2011

Xu, B., Chibber, R., Ruggiero, D., Kohner, E., Ritter, J., Ferro, A., Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products (2003) FASEB J, 17, pp. 1289-1291

Yagi, K., Simple assay for the level of total peroxides in serum or plasma (1998) Methods Mol Biol, 108, pp. 101-106

Yan, S.D., Schmidt, A.M., Anderson, G.M., Zhang, J., Brett, J., Zou, Y.S., Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins (1994) Biol Chem, 269, pp. 9889-9897

Yokoyama, H., Emoto, M., Fujiwara, S., Motoyama, K., Morioka, T., Koyama, H., Short-term aerobic exercise improves arterial stiffness in type 2 diabetes (2004) Diabetes Res Clin Pract, 65, pp. 85-93

Zguira, M.S., Vincent, S., Le Douairon Lahaye, S., Malarde, L., Tabka, Z., Saïag, B., Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta (2013) Cardiovasc Diabetol, 11, pp. 12-32. , 10.1186/1475-2840-12-32

Zhang, H., Park, Y., Zhang, C., Coronary and aortic endothelial function affected bay feedback between adiponectin and tumor necrosis factor α in type 2 diabetic mice (2010) Arterioscler Thromb Vasc Biol, pp. 2156-2163. , 10.1161/ATVBAHA.110.214700

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