dc.creator | Da Silva S.L. | |
dc.creator | Chaar J.D.S. | |
dc.creator | Damico D.C.S. | |
dc.creator | Figueiredo P.D.M.S. | |
dc.creator | Yano T. | |
dc.date | 2008 | |
dc.date | 2015-06-30T19:36:55Z | |
dc.date | 2015-11-26T14:46:07Z | |
dc.date | 2015-06-30T19:36:55Z | |
dc.date | 2015-11-26T14:46:07Z | |
dc.date.accessioned | 2018-03-28T21:55:36Z | |
dc.date.available | 2018-03-28T21:55:36Z | |
dc.identifier | | |
dc.identifier | Pharmaceutical Biology. , v. 46, n. 5, p. 347 - 351, 2008. | |
dc.identifier | 13880209 | |
dc.identifier | 10.1080/13880200801887963 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-42149179940&partnerID=40&md5=72b50096657166780618411ed882f9dc | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/106847 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/106847 | |
dc.identifier | 2-s2.0-42149179940 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1252704 | |
dc.description | Casearia sylvestris Sw., also known as "guaçatonga," is a medicinal plant with broad use in South America. Among the popular applications attributed to this plant are anti-inflammatory, anticancer, antimicrobial, and antiulcer activities. Despite the broad popular use of this plant as a phytopharmaceutical agent, there are few studies about the antimicrobial potential of guaçatonga. In this work, we have studied the antimicrobial potential of an ethanol extract obtained from C. sylvestris leaves against three yeasts, two filamentous fungus, six Gram-negative bacteria, and two Gram-positive bacteria. Through two chromatographic steps using a Sephadex LH-20 column and RP-HPLC, we isolated and characterized two derived compounds of gallic acid: isobutyl gallate-3,5-dimethyl ether (IGDE) and methyl gallate-3,5-dimethyl ether (MGDE). Both compounds showed antimicrobial activity. IGDE was much more efficient than MGDE in inhibiting yeasts (Candida albicans, Candida tropicalis, and Candida guilliermondii) and Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus). This fact is probably associated with the higher hydrophobicity degree of IDGE compared with MGDE. © 2008 Informa Healthcare USA, Inc. | |
dc.description | 46 | |
dc.description | 5 | |
dc.description | 347 | |
dc.description | 351 | |
dc.description | Alves, T.M.A., Biological screening of Brazilian medicinal plants (2000) Memorial do Instituto Oswaldo Cruz, 95, pp. 367-373 | |
dc.description | Barry, A., Procedure for testing antimicrobial agents in agar media: Theoretical considerations (1986) Antibiotics in Laboratory Medicine, pp. 1-26. , Lorian V, ed, 2nd ed. Baltimore. Williams & Wilkins, pp | |
dc.description | Basile, A.C., Sertie, J.A., Panizza, S., Oshiro, T.T., Azzolini, C.A., Pharmacological assay of Casearia sylvestris. 1: Preventive anti-ulcer activity and toxicity of the leaf crude extract (1990) J Ethnopharmacol, 30, pp. 185-197 | |
dc.description | Beutler, J.A., Mccall, K.L., Herbert, K., Herald, D.L., Rettit, G.R., Johnson, T., Shoemaker, R.H., Boyd, M.R., Novel cytotoxic diterpenes from Casearia arborea (2000) J Nat Prod, 63, pp. 657-659 | |
dc.description | Chanwitheesuk, A., Teerawutgulrag, A., Kilburn, J.D., Rakariyatham, N., Antimicrobial gallic acid from Caesalpinia mimosoides Lamk (2007) Food Chem, 100, pp. 1044-1048 | |
dc.description | Chiappeta, A.D., Higher plants with biological activity plants of Pernambuco (1983) Rev Inst Antibiot, 21, pp. 43-50 | |
dc.description | De Mesquita, M.L., Desrivot, J., Bories, C., Fournet, A., De Paula, J.E., Grellier, P., Espindola, L.S., Antileishmanial and trypanocidal activity of Brazilian Cerrado plants (2005) Memorias do Instituto Oswaldo Cruz, 100, pp. 783-787 | |
dc.description | Esteves, I., Souza, I.R., Rodrigues, M., Cardoso, L.G.V., Santos, L.S., Sertie, J.A.A., Perazzo, F.F., Carvalho, J.C.T., Gastric antiulcer and antiinflammatory activities of the essential oil from Casearia sylvestris Sw (2005) J Ethnopharmacol, 101, pp. 191-196 | |
dc.description | Hoffman, H.L., Pfaller, M.A., In vitro antifungal susceptibility testing (2001) Pharmacotherapy, 21, pp. 111-123 | |
dc.description | Kubo, I., Xiao, P., Nihei, K.-I., Fujita, K.-I., Yamagiwa, Y., Kamikawa, T., Molecular design of antifungal agents (2002) J Agric Food Chem, 50, pp. 3992-3998 | |
dc.description | (2002) Plantas Medicinais no Brasil: Nativas e exóticas, pp. 23-24. , Lorenzi H, Matos FJA, eds, Nova Odessa, Inst. Plantarum Est. Flora LTDA, pp | |
dc.description | Maistro, E.L., Carvalho, J.C.T., Mantovani, M.S., Evaluation of the genotoxic potential of the Casearia sylvestris extract on HTC and V79 cells by the comet assay (2004) Toxicol Vitro, 18, pp. 337-342 | |
dc.description | Mans, D.R.A., Da Rocha, A.B., Schwartsmann, G., Anti-cancer drug discovery and development in Brazil: Targeted plant collection as a rational strategy to acquire candidate anticancer compounds (2000) Oncologist 2000, pp. 185-198 | |
dc.description | Menezes, P.R., Schwarz, E.A., Santos, C.A.M., In vitro antioxidant activity of species collected in Paraná (2004) Fitoterapia, 75, pp. 398-400 | |
dc.description | Morita, H., Nakayama, M., Kojima, H., Takeya, K., Itokawa, H., Schenkel, E.P., Motidom, M., Structure and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris SW (1991) Chem Pharm Bull, 39, pp. 693-697 | |
dc.description | Mors, W.B., Nascimento, M.C., Pereira, B.M.R., Pereira, N.A., Plant natural products active against snake bite - the molecular approach (2000) Phytochemistry, 55, pp. 627-642 | |
dc.description | Mosaddik, M.A., Banbury, L., Foster, P., Booth, R., Markham, J., Leach, D., Waterman, P.G., Screening of some Australian Flacourtiaceae species for in vitro antioxidante, cytotoxic and antimicrobial activity (2004) Phytomedicine, 11, pp. 461-466 | |
dc.description | Approved standard M7-45. Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, Villanova, PA (1990) NCCLS, pp. 143-152. , NCCLS National Commitee for Clinical Laboratory Standards | |
dc.description | Raslan, D.S., Jamal, C.M., Duarte, D.S., Borges, M.H., De Lima, M.E., Anti-PLA2 action test of Casearia sylvestris Sw (2002) Boll Chim Farm, 141, pp. 457-460 | |
dc.description | Rodrigues, A.M.S., De Paula, J.E., Degallier, N., Molez, J.F., Espi'ndola, L.S., Larvicidal activity of some Cerrado plant extracts against Aedes aegypti (2006) J Am Mosq Cont Ass, 22, pp. 314-317 | |
dc.description | Shibata, H., Kondo, K., Katsuyama, R., Kawazoe, K., Sato, Y., Murakami, K., Takaishi, Y., Higuti, T., Alkyl gallates, intensifiers of β-lactam susceptibility in methicillin-resistant Staphylococcus aureus (2005) Antimicrob Agents Chemother, 49, pp. 549-555 | |
dc.description | Simões CMO, Shenkel EP, Gosman G, Mello JCP, Mentz LA, Petrovick PR, Eds. (2001): Farmacognosia da planta ao medicamento. ed. Florianópolis, UFRGS/UFSC, pp. 14-39Weniger, B., Theory and instrumentation involved with extraction, control, quality insurance and registration of natural products (1991) First International Advanced Course on Technology and Control of Drugs, pp. 31-40. , Italy, Perugia, pp | |
dc.language | en | |
dc.publisher | | |
dc.relation | Pharmaceutical Biology | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Antimicrobial Activity Of Ethanol Extract From Leaves Of Casearia Sylvestris | |
dc.type | Artículos de revistas | |