The Genetics Of Blood Disorders: Hereditary Hemoglobinopathies

dc.creatorDe Sonati M.F.
dc.creatorCosta F.F.
dc.date2008
dc.date2015-06-30T19:35:59Z
dc.date2015-11-26T14:46:02Z
dc.date2015-06-30T19:35:59Z
dc.date2015-11-26T14:46:02Z
dc.date.accessioned2018-03-28T21:55:29Z
dc.date.available2018-03-28T21:55:29Z
dc.identifier
dc.identifierJornal De Pediatria. , v. 84, n. 4 SUPPL., p. S40 - S51, 2008.
dc.identifier217557
dc.identifier10.2223/JPED.1802
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-57349187681&partnerID=40&md5=b09dd9333bbb208c9322e24d259a7ecf
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106804
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106804
dc.identifier2-s2.0-57349187681
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252676
dc.descriptionObjective: To summarize recently published data on the pathophysiology, diagnosis and treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary hemoglobinopathies in the global population. Sources: Searches were run on the MEDLINE and SCIELO databases, limited to the period from 2003 to May 2008, using the terms hereditary hemoglobinopathies, sickle cell diseases and β-thalassemia. Two books and two chapters were also included. Summary of the findings: More than 2,000 articles were identified; those providing the most important information and broadest views were selected. Conclusions: Morbidity and mortality rates from sickle cell diseases and β-thalassemia are still very high and represent an important challenge. Increased understanding of pathophysiological aspects has lead to significant improvements in treatment and prevention of these diseases. Copyright © 2008 by Sociedade Brasileira de Pediatria.
dc.description84
dc.description4 SUPPL.
dc.descriptionS40
dc.descriptionS51
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dc.descriptionGhavamzadeh, A., Iravani, M., Ashouri, A., Mousavi, S.A., Mahdavi, N., Shamshiri, A., Peripheral blood versus bone marrow as a source of hematopoietic stem cells for allogeneic transplantation in children with class I and II beta thalassemia major (2008) Biol Blood Marrow Transplant, 14, pp. 301-308
dc.descriptionSadelain, M., Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia (2006) Curr Opin Hematol, 13, pp. 142-148
dc.descriptionXie, S.Y., Ren, Z.R., Zhang, J.Z., Guo, X.B., Wang, Q.X., Wang, S., Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach (2007) Hum Mol Genet, 16, pp. 2616-2625
dc.descriptionMoi, P., Sadelain, M., Towards the genetic treatment of beta-thalassemia: New disease models, new vectors, new cells (2008) Haematologica, 93, pp. 325-330
dc.languageen
dc.publisher
dc.relationJornal de Pediatria
dc.rightsaberto
dc.sourceScopus
dc.titleThe Genetics Of Blood Disorders: Hereditary Hemoglobinopathies
dc.typeArtículos de revistas


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