Artículos de revistas
Anaemia Of Cancer: An Overview Of Mechanisms Involved In Its Pathogenesis
Registro en:
Medical Oncology. , v. 25, n. 1, p. 12 - 21, 2008.
13570560
10.1007/s12032-007-9000-8
2-s2.0-42949127743
Autor
Grotto H.Z.W.
Institución
Resumen
Anaemia is a common complication in cancer patients. The decrease in haemoglobin is associated with an impaired quality of life, poorer response to therapy and worse prognosis. Numerous factors are involved in the physiopathology of cancer-related anaemia. Some factors such as bleeding, bone marrow infiltration, the effects of chemoradiotherapy and associated nutritional deficiencies are related to the disease itself. In addition, the interaction of the immune system with iron metabolism and erythropoiesis has been shown to be an important factor in the development of anaemia in cancer patients and can be seen in the action of several cytokines on different iron-homeostasis and erythrocyte-cell-production pathways. 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