dc.creator | Pacheco A.R. | |
dc.creator | Proenca-Modena J.L. | |
dc.creator | Sales A.I.L. | |
dc.creator | Fukuhara Y. | |
dc.creator | Da Silveira W.D. | |
dc.creator | Pimenta-Modena J.L. | |
dc.creator | De Oliveira R.B. | |
dc.creator | Brocchi M. | |
dc.date | 2008 | |
dc.date | 2015-06-30T19:33:59Z | |
dc.date | 2015-11-26T14:45:39Z | |
dc.date | 2015-06-30T19:33:59Z | |
dc.date | 2015-11-26T14:45:39Z | |
dc.date.accessioned | 2018-03-28T21:54:55Z | |
dc.date.available | 2018-03-28T21:54:55Z | |
dc.identifier | | |
dc.identifier | European Journal Of Clinical Microbiology And Infectious Diseases. , v. 27, n. 11, p. 1053 - 1059, 2008. | |
dc.identifier | 9349723 | |
dc.identifier | 10.1007/s10096-008-0549-8 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-55549134310&partnerID=40&md5=4bd3bbd7c97cd789b5d144564cfc160e | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/106686 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/106686 | |
dc.identifier | 2-s2.0-55549134310 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1252539 | |
dc.description | Infection by Helicobacter pylori is associated with the development of several gastroduodenal diseases, including gastritis, peptic ulcer disease (gastric ulcers and duodenal ulcers), and gastric adenocarcinoma. Although a number of putative virulence factors have been reported for H. pylori, there are conflicting results regarding their association with specific H. pylori-related diseases. In this work, we investigated the presence of virB11 and cagT, located in the left half of the cag pathogenicity island (cagPAI), and the jhp917-jhp918 sequences, components of the dupA gene located in the plasticity zone of H. pylori, in Brazilian isolates of H. pylori. We also examined the association between these genes and H. pylori-related gastritis, peptic ulcer disease, and gastric and duodenal ulcers in an attempt to identify a gene marker for clinical outcomes related to infection by H. pylori. The cagT gene was associated with peptic ulcer disease and gastric ulcers, whereas the virB11 gene was detected in nearly all of the samples. The dupA gene was not associated with duodenal ulcers or any gastroduodenal disease here analyzed. These results suggest that cagT could be a useful prognostic marker for the development of peptic ulcer disease in the state of São Paulo, Brazil. They also indicate that cagT is associated with greater virulence and peptic ulceration, and that this gene is an essential component of the type IV secretion system of H. pylori. © 2008 Springer-Verlag. | |
dc.description | 27 | |
dc.description | 11 | |
dc.description | 1053 | |
dc.description | 1059 | |
dc.description | Suerbaum, S., Josenhans, C., Helicobacter pylori evolution and phenotypic diversification in a changing host (2007) Nat Rev Microbiol, 5, pp. 441-452 | |
dc.description | Covacci, A., Telford, J.L., Del Giudice, G., Parsonnet, J., Rappuoli, R., Helicobacter pylori virulence and genetic geography (1999) Science, 284, pp. 1328-1333 | |
dc.description | Proença-Módena, J.L., Sales, A.I.L., Acrani, G.O., Russo, R., Ribeiro, M.A.V., Fukuhara, Y., Da Silveira, W.D., Brocchi, M., Association between Helicobacter pylori genotypes and gastric disorders in relation to the cag pathogenicity island (2007) Diagn Microbiol Infect Dis, 59, pp. 7-16 | |
dc.description | Blaser, M.J., Atherton, J.C., Helicobacter pylori persistence: Biology and disease (2004) J Clin Invest, 113, pp. 321-333 | |
dc.description | Censini, S., Lange, C., Xiang, Z., Crabtree, J.E., Ghiara, P., Borodovsky, M., Rappuoli, R., Covacci, A., Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors (1996) Proc Natl Acd Sci USA, 93, pp. 14648-14653 | |
dc.description | Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., Haas, R., Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion (2000) Science, 287, pp. 1497-1500 | |
dc.description | Fischer, W., Püls, J., Buhrdorf, R., Gebert, B., Odenbreit, S., Haas, R., Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8 (2001) Mol Microbiol, 42, pp. 1337-1348 | |
dc.description | Selbach, M., Moese, S., Hurwitz, R., Hauck, C.R., Meyer, T.F., Backert, S., The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation (2003) EMBO J, 22, pp. 515-528 | |
dc.description | Ramarao, B., Gray-Owen, S.D., Backert, S., Meyer, T.F., Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components (2000) Mol Microbiol, 37, pp. 1389-1404 | |
dc.description | Proença-Módena, J.L., Acrani, G.O., Micas, A.F.D., Castro, M., Silveira, W.D., Pimenta-Módena, J.L., De Oliveira, R.B., Brocchi, M., Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil (2007) Braz J Infect Dis, 11, pp. 89-95 | |
dc.description | Mattar, R., Marques, S.B., Monteiro Mdo, S., Dos Santos, A.F., Iriya, K., Carrilho, F.J., Helicobacter pylori cag pathogenicity island genes: Clinical relevance for peptic ulcer disease development in Brazil (2007) J Med Microbiol, 56, pp. 9-14 | |
dc.description | Santos, A., Queiroz, D.M.M., Ménard, A., Marais, A., Rocha, G.A., Oliveira, C.A., Ammf, N., Mégraud, F., New pathogenicity marker found in the plasticity region of the Helicobacter pylori genome (2003) J Clin Microbiol, 41, pp. 1651-1655 | |
dc.description | De Jonge, R., Kuipers, E.J., Langeveld, S.C., Loffeld, R.J., Stoof, J., Van Vliet, A.H., Kusters, J.G., The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells (2004) FEMS Immunol Med Microbiol, 41, pp. 161-167 | |
dc.description | Lu, H., Hsu, P.I., Graham, D.Y., Yamaoka, Y., Duodenal ulcer promoting gene of Helicobacter pylori (2005) Gastroenterology, 128, pp. 833-848 | |
dc.description | Argent, R.H., Burette, A., Miendje Deyi, V.Y., Atherton, J.C., The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America (2007) Clin Infect Dis, 45, pp. 1204-1206 | |
dc.description | Gomes, L.I., Rocha, G.A., Rocha, A.M., Soares, T.F., Oliveira, C.A., Bittencourt, P.F., Queiroz, D.M., Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients (2008) Int J Med Microbiol, 298, pp. 223-230 | |
dc.description | Glupczynski, Y., Lee, A., Mégraud, F., Culture of Helicobacter pylori from gastric biopsies and antimicrobial susceptibility testing (1996) Helicobacter Pylori: Techniques for Clinical Diagnosis, pp. 17-32. , WB Saunders London, UK | |
dc.description | Brocchi, M., Covone, M.G., Palla, E., Galeotti, C.L., Integration of minitransposons for expression of the Escherichia coli elt genes at a preferred site in Salmonella typhimurium identifies a novel putative fimbrial locus (1999) Arch Microbiol, 171, pp. 122-126 | |
dc.description | Sambrook, J., Russell, D.W., (2001) Molecular Cloning: A Laboratory Manual, p. 999. , Cold Spring Harbor Laboratory Press New York | |
dc.description | Hanahan, D., Jessee, J., Bloom, F.R., Plasmid transformation of Escherichia coli and other bacteria (1991) Methods Enzymol, 204, pp. 63-113 | |
dc.description | Clayton, C.L., Kleanthous, H., Coates, P.J., Morgan, D.D., Tabaqchali, S., Sensitive detection of Helicobacter pylori by using polymerase chain reaction (1992) J Clin Microbiol, 30, pp. 192-200 | |
dc.description | Tomasini, M.L., Zanussi, S., Sozzi, M., Tedeschi, R., Basaglia, G., De Paoli, P., Heterogeneity of cag genotypes in Helicobacter pylori isolates from human biopsy specimens (2003) J Clin Microbiol, 41, pp. 976-980 | |
dc.description | Ali, M., Khan, A.A., Tiwari, S.K., Ahmed, N., Rao, L.V., Habibullah, C.M., Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes (2005) World J Gastroenterol, 11, pp. 6815-6822 | |
dc.description | Brocchi, M., Vasconcelos, A.T.R., Zaha, A., Restriction-modification systems in Mycoplasma spp. (2007) Gen Mol Biol, 30, pp. 236-244 | |
dc.description | Cascales, E., Christie, P.J., The versatile bacterial type IV secretion systems (2003) Nat Rev Microbiol, 1, pp. 137-149 | |
dc.description | Christie, P.J., Atmakuri, K., Krishnamoorthy, V., Jakubowski, S., Cascales, E., Biogenesis, architecture, and function of bacterial type IV secretion systems (2005) Annu Rev Microbiol, 59, pp. 451-485 | |
dc.description | Kauser, F., Hussain, M.A., Ahmed, I., Srinivas, S., Devi, S.M., Majeed, A.A., Rao, K.R., Ahmed, N., Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England (2005) BMC Microbiol, 5, p. 32 | |
dc.description | Ikenoue, T., Maeda, S., Ogura, K., Akanuma, M., Mitsuno, Y., Imai, Y., Yoshidam, H., Omata, M., Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island (2001) Clin Diagn Lab Immunol, 8, pp. 181-186 | |
dc.description | Rohde, M., Püls, J., Buhrdorf, R., Fischer, W., Hass, R., A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system (2003) Mol Microbiol, 49, pp. 219-234 | |
dc.description | Atherton, J.C., Peek Jr., R.M., Tham, K.T., Cover, T.L., Blaser, M.J., Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori (1997) Gastroenterology, 112, pp. 92-99 | |
dc.description | Akopyants, N.S., Clifton, S.W., Kersulyte, D., Crabtree, J.E., Youree, B.E., Reece, C.A., Bukanov, N.O., Berg, D.E., Analyses of the cag pathogenicity island of Helicobacter pylori (1998) Mol Microbiol, 28, pp. 37-53 | |
dc.description | Maeda, S., Yoshida, H., Ikenoue, T., Ogura, K., Kanai, F., Kato, N., Shiratori, Y., Omata, M., Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates (1999) Gut, 44, pp. 336-341 | |
dc.description | Blomstergren, A., Lundin, A., Nilsson, C., Engstrand, L., Lundeberg, J., Comparative analysis of the complete cag pathogenicity island sequence in four Helicobacter pylori isolates (2004) Gene, 328, pp. 85-93 | |
dc.description | Alm, R.A., Trust, T.J., Analysis of the genetic diversity of Helicobacter pylori: The tale of two genomes (1999) J Mol Med, 77, pp. 834-846 | |
dc.description | Chanto, G., Occhialini, A., Gras, N., Alm, R.A., Mégraud, F., Marais, A., Identification of strain-specific genes located outside the plasticity zone in nine clinical isolates of Helicobacter pylori (2002) Microbiology, 148, pp. 3671-3680 | |
dc.language | en | |
dc.publisher | | |
dc.relation | European Journal of Clinical Microbiology and Infectious Diseases | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Involvement Of The Helicobacter Pylori Plasticity Region And Cag Pathogenicity Island Genes In The Development Of Gastroduodenal Diseases | |
dc.type | Artículos de revistas | |