Adverse Effect Of The Anabolic-androgenic Steroid Mesterolone On Cardiac Remodelling And Lipoprotein Profile Is Attenuated By Aerobicz Exercise Training

dc.creatorFontana K.
dc.creatorOliveira H.C.F.
dc.creatorLeonardo M.B.
dc.creatorMandarim-De-Lacerda C.A.
dc.creatorDa Cruz-Hofling M.A.
dc.date2008
dc.date2015-06-30T19:34:21Z
dc.date2015-11-26T14:45:37Z
dc.date2015-06-30T19:34:21Z
dc.date2015-11-26T14:45:37Z
dc.date.accessioned2018-03-28T21:54:53Z
dc.date.available2018-03-28T21:54:53Z
dc.identifier
dc.identifierInternational Journal Of Experimental Pathology. , v. 89, n. 5, p. 358 - 366, 2008.
dc.identifier9599673
dc.identifier10.1111/j.1365-2613.2008.00601.x
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-51349094273&partnerID=40&md5=21318f3c6e08d2e39a906128334db923
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106707
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106707
dc.identifier2-s2.0-51349094273
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252530
dc.descriptionAbuse of anabolic-androgenic steroids (AAS) for improving physical performance is associated with serious, sometimes fatal, adverse effects. The aim of the present work was to investigate the effects of AAS on the cardiac structure and the plasma lipoprotein profile isolated and in combination with exercise. Transgenic mice with a human lipaemic phenotype (expressing cholesteryl ester transfer protein on the LDL receptor knockout background) were used in this study. Sedentary and exercised mice (treadmill running, five times per week for 6 weeks) were treated with mesterolone (2 μg/g body weight) or vehicle (control-C) in the last 3 weeks. Four groups were compared: (i) exercise + mesterolone (Ex-M), (ii) exercise + vehicle (Ex-C), (iii) sedentary + mesterolone (Sed-M) and (iv) sedentary + vehicle (Sed-C). Arterial blood pressure and body mass increased in all groups along time, but Sed-M reached the highest values and Ex-C the lowest. Treatment with mesterolone increased total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c) and very LDL-c (VLDL-c) plasma levels. However, exercise blunted some of these deleterious effects by increasing high-density lipoprotein cholesterol and decreasing LDL-c, VLDL-c and triglycerides. Exercise training induced beneficial effects, such as physiological cardiomyocyte hypertrophy, increase in myocardial circulation and decrease in cardiac interstitium. However, mesterolone impaired such physiological gains and in addition increased troponin T plasma levels both in sedentary and exercised mice. Thus, while mesterolone induced pro-atherogenic lipoprotein profile and pathogenic cardiac hypertrophy, exercise counteracted these effects and modified favourably both the lipoprotein profile and the cardiac remodelling induced by mesterolone. © 2008 The Authors.
dc.description89
dc.description5
dc.description358
dc.description366
dc.descriptionAlen, M., Rahkila, P., Reduced high-density lipoprotein-cholesterol in power athletes: Use of male sex hormone derivates, an atherogenic factor (1984) Int. J. Sports Med., 5, pp. 341-342
dc.descriptionBasaria, S., Wahlstrom, J.T., Dobs, A.S., Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases (2001) J. Clin. Endocrinol. Metab., 86, pp. 5108-5117
dc.descriptionBauman, D.H., Richerson, J.T., Britt, A.L., A comparison of body and organ weights, physiologic parameters, and pathologic changes in target organs of rats given combinations of exercise, anabolic hormone, and protein supplementation (1988) Am. J. Sports Med., 16, pp. 397-402
dc.descriptionBlair, S.N., Lamonte, M.J., Nichaman, M.Z., The evolution of physical activity recommendations: How much is enough? (2004) Am. J. Clin. Nutr., 79, pp. 913S-920S
dc.descriptionCasquero, A.C., Berti, J.A., Salerno, A.G., Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice (2006) J. Lipid Res., 47, pp. 1526-1534
dc.descriptionCazita, P.M., Berti, J.A., Aoki, C., Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice (2003) J. Lipid Res., 44, pp. 33-40
dc.descriptionCodipilly, C.N., Teichberg, S., Wapnir, R.A., Enhancement of absorption by gum arabic in a model of gastrointestinal dysfunction (2006) J. Am. Coll. Nutr., 25, pp. 307-312
dc.descriptionDickerman, R.D., McConathy, W.J., Schaller, F., Cardiovascular complications and anabolic steroids (1996) Eur. Heart J., 17, p. 1912
dc.descriptionFriedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge (1972) Clin. Chem., 18, pp. 499-502
dc.descriptionGanten, U., Schroder, G., Witt, M., Sexual dimorphism of blood pressure in spontaneously hypertensive rats: Effects of anti-androgen treatment (1989) J. Hypertens., 7, pp. 721-726
dc.descriptionGlazer, G., Atherogenic effects of anabolic steroids on serum lipid levels. a literature review (1991) Arch. Intern. Med., 151, pp. 1925-1933
dc.descriptionGundersen, H.J., Notes on the estimation of the numerical density of arbitrary profiles: The edge effect (1977) J. Microsc., 111, pp. 219-227
dc.descriptionHalverstadt, A., Phares, D.A., Wilund, K.R., Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women (2007) Metabolism, 56, pp. 444-450
dc.descriptionHartgens, F., Kuipers, H., Effects of androgenic-anabolic steroids in athletes (2004) Sports Med., 34, pp. 513-554
dc.descriptionHurley, B.F., Seals, D.R., Hagberg, J.M., High-density-lipoprotein cholesterol in bodybuilders v powerlifters. Negative effects of androgen use (1984) J. Am. Med. Assoc., 252, pp. 507-513
dc.descriptionKraus, W.E., Houmard, J.A., Duscha, B.D., Effects of the amount and intensity of exercise on plasma lipoproteins (2002) N. Engl. J. Med., 347, pp. 1483-1492
dc.descriptionLarosa, J.C., Lipids and cardiovascular disease: Do the findings and therapy apply equally to men and women? (1992) Womens Health Issues, 2, pp. 102-111
dc.descriptionMandarim-De-Lacerda, C.A., Stereological tools in biomedical research (2003) Ann. Braz. Acad. Sci., 75, pp. 469-486
dc.descriptionMarques, C.M., Nascimento, F.A., Mandarim-De-Lacerda, C.A., Exercise training attenuates cardiovascular adverse remodeling in adult ovariectomized spontaneously hypertensive rats (2006) Menopause, 13, pp. 87-95
dc.descriptionNieminen, M.S., Ramo, M.P., Viitasalo, M., Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters (1996) Eur. Heart J., 17, pp. 1576-1583
dc.descriptionRockhold, R.W., Cardiovascular toxicity of anabolic steroids (1993) Annu. Rev. Pharmacol. Toxicol., 33, pp. 497-520
dc.descriptionSeals, D.R., Hagberg, J.M., Hurley, B.F., Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women (1984) JAMA, 252, pp. 645-649
dc.descriptionSmolka, M.B., Zoppi, C.C., Alves, A.A., HSP72 as a complementary protection against oxidative stress induced by exercise in the soleus muscle of rats (2000) Am. J. Physiol. Regul. Integr. Comp. Physiol., 279, pp. R1539-R1545
dc.descriptionSullivan, M.L., Martinez, C.M., Gennis, P., The cardiac toxicity of anabolic steroids (1998) Prog. Cardiovasc. Dis., 41, pp. 1-15
dc.descriptionTagarakis, C.V., Bloch, W., Hartmann, G., Anabolic steroids impair the exercise-induced growth of the cardiac capillary bed (2000) Int. J. Sports Med., 21, pp. 412-418
dc.descriptionTagarakis, C.V., Bloch, W., Hartmann, G., Testosterone-propionate impairs the response of the cardiac capillary bed to exercise (2000) Med. Sci. Sports Exerc., 32, pp. 946-953
dc.descriptionUrhausen, A., Albers, T., Kindermann, W., Are the cardiac effects of anabolic steroid abuse in strength athletes reversible? (2004) Heart, 90, pp. 496-501
dc.descriptionVermeulen, A., Androgen replacement therapy in the aging male - A critical evaluation (2001) J. Clin. Endocrinol. Metab., 86, pp. 2380-2390
dc.descriptionWang, M., Tsai, B.M., Kher, A., Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion (2005) Am. J. Physiol. Heart Circ. Physiol., 288, pp. H221-H226
dc.descriptionWinkler, U.H., Effects of androgens on haemostasis (1996) Maturitas, 24, pp. 147-155
dc.descriptionWoodiwiss, A.J., Trifunovic, B., Philippides, M., Effects of an androgenic steroid on exercise-induced cardiac remodeling in rats (2000) J. Appl. Physiol., 88, pp. 409-415
dc.languageen
dc.publisher
dc.relationInternational Journal of Experimental Pathology
dc.rightsfechado
dc.sourceScopus
dc.titleAdverse Effect Of The Anabolic-androgenic Steroid Mesterolone On Cardiac Remodelling And Lipoprotein Profile Is Attenuated By Aerobicz Exercise Training
dc.typeArtículos de revistas


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