S-nitroso-n-acetylcysteine (snac) Prevents Myocardial Alterations In Hypercholesterolemic Ldl Receptor Knockout Mice By Antiinflammatory Action

dc.creatorGarcia J.A.D.
dc.creatorDos Santos L.
dc.creatorMoura A.L.
dc.creatorRicardo K.F.S.
dc.creatorWanschel A.C.B.A.
dc.creatorShishido S.M.
dc.creatorSpadari-Bratfisch R.C.
dc.creatorDe Souza H.P.
dc.creatorKrieger M.H.
dc.date2008
dc.date2015-06-30T19:29:15Z
dc.date2015-11-26T14:44:50Z
dc.date2015-06-30T19:29:15Z
dc.date2015-11-26T14:44:50Z
dc.date.accessioned2018-03-28T21:53:51Z
dc.date.available2018-03-28T21:53:51Z
dc.identifier
dc.identifierJournal Of Cardiovascular Pharmacology. , v. 51, n. 1, p. 78 - 85, 2008.
dc.identifier1602446
dc.identifier10.1097/FJC.0b013e31815c39d4
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-38349115415&partnerID=40&md5=957c38c79992560f8f68ed4857c14789
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/106435
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106435
dc.identifier2-s2.0-38349115415
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1252275
dc.descriptionWe investigated the ability of S-nitroso-N-acetylcyseine (SNAC) to prevent structural and functional myocardial alterations in hypercholesterolemic mice. C57BL6 wild-type (WT) and LDL-R-/- male mice (S) were fed a standard diet for 15 days. LDL-R-/- mice (S) showed an 11% increase in blood pressure, 62% decrease in left atrial contractility, and lower CD40L and eNOS expression relative to WT. LDL-R-/- mice fed an atherogenic diet for 15 days (Chol) showed significant increased left ventricular mass compared to S, which was characterized by: (1) 1.25-fold increase in the LV weight/body weight ratio and cardiomyocyte diameter; (2) enhanced expression of the NOS isoforms, CD40L, and collagen amount; and (3) no alteration in the atrial contractile performance. Administration of SNAC to Chol mice (Chol + SNAC) (0.51 μmol/kg/day for 15 day, IP) prevented increased left ventricular mass, collagen deposit, NOS isoforms, and CD40L overexpression, but it had no effect on the increased blood pressure or atrial basal hypocontractility. Deletion of the LDL receptor gene in mice resulted in hypertension and a marked left atrial contractile deficit, which may be related to eNOS underexpression. Our data show that SNAC treatment has an antiinflammatory action that might contribute to prevention of structural and functional myocardial alterations in atherosclerotic mice independently of changes in blood pressure. © 2008 Lippincott Williams & Wilkins, Inc.
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dc.languageen
dc.publisher
dc.relationJournal of Cardiovascular Pharmacology
dc.rightsfechado
dc.sourceScopus
dc.titleS-nitroso-n-acetylcysteine (snac) Prevents Myocardial Alterations In Hypercholesterolemic Ldl Receptor Knockout Mice By Antiinflammatory Action
dc.typeArtículos de revistas


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